{ "schema_version": 1, "kind": "condition", "id": "acute-conjunctivitis", "name": "Acute bacterial conjunctivitis", "category": "infectious", "sources": "AAO Preferred Practice Pattern: Conjunctivitis 2018 · Chloramphenicol 0.5% w/v Antibiotic Eye Drops SmPC section 4.2 (eMC product 9662) · DailyMed Tobramycin Ophthalmic Solution 0.3% Package Insert (SetID 8f244ffb-14d2-45e3-9993-9c865f80b2a7) · Egyptian National Drug Formulary - Antimicrobial 2023 (gatifloxacin monograph)", "review_status": "reviewed", "verified_against": "Chloramphenicol 0.5% w/v Antibiotic Eye Drops SmPC section 4.2 (eMC product 9662) · DailyMed Tobramycin Ophthalmic Solution 0.3% Package Insert (SetID 8f244ffb-14d2-45e3-9993-9c865f80b2a7) · Egyptian National Drug Formulary - Antimicrobial 2023 (gatifloxacin monograph) · Acute bacterial conjunctivitis - disease-level clinical article (acute-conjunctivitis-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 37, "generic": "Chloramphenicol", "line": 1, "is_adjunct": false, "form": "eye", "strength_mg": null, "adult_dose": "Instil 0.5% eye drops 1 drop every 2 hours initially, reducing to QID as infection clears", "adult_duration": "5 days", "dose_source": "Chloramphenicol 0.5% w/v Antibiotic Eye Drops SmPC section 4.2 (eMC product 9662)", "rationale": "Broad-spectrum topical antibacterial of choice in UK/Egyptian practice", "cautions": [ "Avoid long-term use due to rare risk of aplastic anemia.", "Store eye drops in refrigerator (2-8C).", "The label gives one drop every 2 hours for the first 48 hours, then every 4 hours, during waking hours only, for a 5-day course. It is licensed from 2 years; below that, and especially in a newborn, treat as a specialist problem." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Chloramphenicol is broad spectrum antibiotic indicated in both adults and children aged 2 years and over for the treatment of acute bacterial conjunctivitis.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "2 years and over", "age_min_months": 24, "age_max_months": 216, "dose_text": "As for an adult - indicated from 2 years for acute bacterial conjunctivitis." } ], "peds_doses": null, "brands": [ { "trade_name": "OPHTAMYCETINE 0.5% EYE DROPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 2.65, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CHLORAMPHENICOL 0.5% EYE DROPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 3.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "OPTOCETINE 0.5% EYE DROPS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 4.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ISOMIPHENICOL 0.5% EYE DROPS 10 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR", "price_egp": 4.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ISOPTOFENICOL 0.5% EYE DROPS 15 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > ALCON", "price_egp": 9.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "OCUPHENICOL 0.5% EYE DPS. 10 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MIPHENICOL 1% EYE OINT. 5 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR", "price_egp": 4.0, "pack_count": null, "unit_price": null, "strength_mg": 5000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EPIPHENICOL 1% EYE OINT. 5 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": 5000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "acute-conjunctivitis" }, { "id": 38, "generic": "Tobramycin", "line": 1, "is_adjunct": false, "form": "eye", "strength_mg": null, "adult_dose": "Instil 0.3% ophthalmic solution 1-2 drops into affected eye(s) every 4 hours for 5-7 days (in severe infections, 2 drops every hour until improvement)", "adult_duration": null, "dose_source": "DailyMed Tobramycin Ophthalmic Solution 0.3% Package Insert (SetID 8f244ffb-14d2-45e3-9993-9c865f80b2a7)", "rationale": "Effective aminoglycoside option for bacterial conjunctivitis", "cautions": [ "Topical hypersensitivity reactions (eyelid itching, swelling) may occur.", "Avoid contact lens wear during active eye infection.", "Prolonged use may result in superinfection with non-susceptible organisms." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Children >2 months: instil 1 drop into affected eye(s) every 4 hours for 5-7 days", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "3 months and over", "age_min_months": 3, "age_max_months": 216, "dose_text": "1 drop into affected eye every 4 hours for 5 to 7 days." } ], "peds_doses": null, "brands": [ { "trade_name": "SWIXTOBRAM 0.3% EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CHEMIPHARM", "price_egp": 6.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "T GRAND 0.3% EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DELTA GRAND PHARMA", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TOBRAL 0.3% EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TOBRACTIVA 0.3% EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EPCI", "price_egp": 18.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AVAZIR 0.3% EYE DROPS 10 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORCHIDIA PHARMACEUTICAL INDUSTRIES > ORCHIDIA", "price_egp": 28.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TOBREX 0.3% EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "NOVARTIS > NOVARTIS SCIENTIFIC OFFICE", "price_egp": 32.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TOBRIN 0.3% EYE.OINT. 5 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 23.0, "pack_count": null, "unit_price": null, "strength_mg": 5000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AVAZIR 0.3% EYE OINT. 5 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORCHIDIA PHARMACEUTICAL INDUSTRIES > ORCHIDIA", "price_egp": 26.0, "pack_count": null, "unit_price": null, "strength_mg": 5000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "acute-conjunctivitis" }, { "id": 40, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Bacterial Conjunctivitis - disease-level clinical article (acute-conjunctivitis-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Instruct contact lens wearers to remove lenses during treatment." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "acute-conjunctivitis" }, { "id": 39, "generic": "Gatifloxacin", "line": 2, "is_adjunct": false, "form": "eye", "strength_mg": null, "adult_dose": "0.3% solution: 1 drop into the affected eye(s) every 2 hours while awake on days 1 and 2 (maximum 8 times a day), then 1 drop 4 times a day while awake on days 3 to 7. 0.5% solution: 1 drop every 2 hours while awake on day 1 (maximum 8 times a day), then 1 drop 2 to 4 times a day on days 2 to 7", "adult_duration": "7 days", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (gatifloxacin monograph)", "rationale": "12 live products, all ophthalmic, and the formulary's only listed indication is bacterial conjunctivitis. Broader Gram-negative cover than chloramphenicol, which matters in a contact-lens wearer where Pseudomonas must be covered.", "cautions": [ "Most acute conjunctivitis is viral and self-limiting - do not prescribe an antibiotic drop reflexively.", "Reserve a fluoroquinolone drop for contact-lens wearers, for suspected Pseudomonas, or for failure of chloramphenicol - routine use breeds resistance.", "Pain, photophobia, reduced vision or a corneal opacity is keratitis, not conjunctivitis - refer the same day.", "Remove contact lenses and do not wear them until the eye is white and the course is finished.", "Discard the bottle 4 weeks after opening.", "Never inject ophthalmic solution into the eye." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "The formulary gives a single regimen for adults and children alike - the same drop schedule. No mg/kg dosing applies to eye drops.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "OCCUBACT 0.3% EYE DPS. 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA TEC", "price_egp": 13.2, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GATIGRAND 0.3% EYE DPS. 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DELTA GRAND PHARMA", "price_egp": 14.4, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GATIPRAM 0.3% EYE DROPS. 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA > MODERN OFFICE FOR IMPORT", "price_egp": 14.4, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SOLOGATI 0.3% EYE DPS. 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GRAND PHARMA > CITY PHARMA", "price_egp": 16.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GATYXEL 0.3% EYE OINT 5 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORCHIDIA PHARMACEUTICAL INDUSTRIES > ORCHIDIA", "price_egp": 25.5, "pack_count": null, "unit_price": null, "strength_mg": 5000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PHARMAGATIN 0.3% EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > PHARMA MEDICA", "price_egp": 27.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TYMER 0.3% EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JAMJOOM PHARMACEUTICALS", "price_egp": 66.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "acute-conjunctivitis" } ] }