{
  "schema_version": 1,
  "kind": "condition",
  "id": "acute-sialadenitis",
  "name": "Acute suppurative sialadenitis (parotitis)",
  "category": "infectious",
  "sources": "IDSA Guidelines · Egyptian National Drug Formulary - Antimicrobial 2023 (clindamycin monograph)",
  "review_status": "reviewed",
  "verified_against": "Egyptian National Drug Formulary - Antimicrobial 2023 (clindamycin monograph)",
  "verified_date": "2026-08",
  "treatments": [
    {
      "id": 90,
      "generic": "Amoxicillin + Clavulanic acid",
      "line": 1,
      "is_adjunct": false,
      "form": "oral.solid",
      "strength_mg": 875.0,
      "adult_dose": "875/125 mg orally twice daily (or 500/125 mg 3 times daily) with meals",
      "adult_duration": "5 to 7 days for mild to moderate infection and 10 days for severe infection",
      "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023",
      "rationale": "First-line oral antibiotic providing cover against S. aureus, S. pneumoniae, and oral anaerobes",
      "cautions": [
        "Encourage sialogogues (lemon drops/sour candies), hydration, and gentle salivary gland massage.",
        "Contraindicated in penicillin hypersensitivity or history of co-amoxiclav jaundice.",
        "Refer urgently if fluctuation, abscess formation, or airway compromise develops."
      ],
      "peds_mgkg_low": 25.0,
      "peds_mgkg_high": 45.0,
      "peds_max_mg": 1750.0,
      "peds_basis": "day",
      "peds_unit": "mg",
      "peds_note": "Child >3 months: 25-45 mg/kg/day divided BID based on amoxicillin component",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": [
        {
          "weight_kg": 10,
          "low_mg": 250,
          "high_mg": 450,
          "capped": false
        },
        {
          "weight_kg": 20,
          "low_mg": 500,
          "high_mg": 900,
          "capped": false
        },
        {
          "weight_kg": 30,
          "low_mg": 750,
          "high_mg": 1350,
          "capped": false
        },
        {
          "weight_kg": 40,
          "low_mg": 1000,
          "high_mg": 1750,
          "capped": true
        }
      ],
      "brands": [
        {
          "trade_name": "E-MOXCLAV 1G 10 F.C. TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "EIPICO",
          "price_egp": 14.0,
          "pack_count": 10,
          "unit_price": 1.4,
          "strength_mg": 1000.0,
          "exact_strength": false,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "AUJED 625 MG 12 F.C. TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "SIGMA TEC > JEDCO INT. CO. FOR PHARMACEUTICALS",
          "price_egp": 19.2,
          "pack_count": 12,
          "unit_price": 1.6,
          "strength_mg": 625.0,
          "exact_strength": false,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "E-MOXCLAV 375MG 10 F.C. TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "EIPICO",
          "price_egp": 20.4,
          "pack_count": 10,
          "unit_price": 2.04,
          "strength_mg": 375.0,
          "exact_strength": false,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "MAGNABIOTIC 625MG 8 TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "SEDICO",
          "price_egp": 37.0,
          "pack_count": 8,
          "unit_price": 4.62,
          "strength_mg": 625.0,
          "exact_strength": false,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "CURAM 625MG 12 F.C.TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "SANDOZ > NOVARTIS",
          "price_egp": 108.0,
          "pack_count": 12,
          "unit_price": 9.0,
          "strength_mg": 625.0,
          "exact_strength": false,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "AUGMENTIN 625 MG 10 F.C.TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "MUP > SMITHKLINE BEECHAM",
          "price_egp": 117.0,
          "pack_count": 10,
          "unit_price": 11.7,
          "strength_mg": 625.0,
          "exact_strength": false,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "CLAVOCILLIN 1 GM 10 DISPERSIBLE TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "RAMEDA > ORGANOPHARMA",
          "price_egp": 106.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 1000.0,
          "exact_strength": false,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "AUGMENTIN ADULTS 1GM/125MG 12 PWD. ORAL SUSP. SACHETS",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "GLAXO SMITHKLINE",
          "price_egp": 169.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 1000.0,
          "exact_strength": false,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "LARYNCLAVE 125/31 PD. FOR ORAL SUSP. 70ML",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "MISR > AL ROWAD PHARMACEUTICAL INDUSTRIAL CO.",
          "price_egp": 8.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": null,
          "exact_strength": false,
          "exact_form": false,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "MEGACLAVOX 156MG/5ML PD. FOR SUSP. 60 ML",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "CID",
          "price_egp": 8.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 156.0,
          "exact_strength": false,
          "exact_form": false,
          "discontinued": false,
          "also_contains": null
        }
      ],
      "condition_id": "acute-sialadenitis"
    },
    {
      "id": 91,
      "generic": "Clindamycin",
      "line": 2,
      "is_adjunct": false,
      "form": "oral.solid",
      "strength_mg": 300.0,
      "adult_dose": "300-450 mg 4 times daily orally",
      "adult_duration": null,
      "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (clindamycin monograph)",
      "rationale": "Alternative for penicillin-allergic patients providing potent staphylococcal and anaerobic activity",
      "cautions": [
        "Black box warning: there is a risk of Clostridioides difficile pseudomembranous colitis; stop if severe diarrhea occurs."
      ],
      "peds_mgkg_low": 10.0,
      "peds_mgkg_high": 25.0,
      "peds_max_mg": 1800.0,
      "peds_basis": "day",
      "peds_unit": "mg",
      "peds_note": "Child: 10-25 mg/kg/day divided TID-QID",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": [
        {
          "weight_kg": 10,
          "low_mg": 100,
          "high_mg": 250,
          "capped": false
        },
        {
          "weight_kg": 20,
          "low_mg": 200,
          "high_mg": 500,
          "capped": false
        },
        {
          "weight_kg": 30,
          "low_mg": 300,
          "high_mg": 750,
          "capped": false
        },
        {
          "weight_kg": 40,
          "low_mg": 400,
          "high_mg": 1000,
          "capped": false
        }
      ],
      "brands": [
        {
          "trade_name": "ADCOCLINDACE 300 MG 16 CAPS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "ARAB DRUG COMPANY (ADCO)",
          "price_egp": 24.0,
          "pack_count": 16,
          "unit_price": 1.5,
          "strength_mg": 300.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "CLINACYN 300MG 16 CAPS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "SIGMA > EGYPTIAN PHARMACISTS COMPANY",
          "price_egp": 31.5,
          "pack_count": 16,
          "unit_price": 1.97,
          "strength_mg": 300.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "CLINDAM 300 MG 16 CAPS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "SIGMA > OCTOBER PHARMA",
          "price_egp": 75.0,
          "pack_count": 16,
          "unit_price": 4.69,
          "strength_mg": 300.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "MEPACLIND 300MG 8 CAPS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "MEPACO",
          "price_egp": 38.0,
          "pack_count": 8,
          "unit_price": 4.75,
          "strength_mg": 300.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "CLINDACINE ART 300 MG 12 CAPS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "RAMEDA > ART PHARMA",
          "price_egp": 76.0,
          "pack_count": 12,
          "unit_price": 6.33,
          "strength_mg": 300.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "ALFACLINDAMYCIN 300 MG 10 CAPS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "ATCO PHARMA > ROTABIOGEN",
          "price_egp": 69.0,
          "pack_count": 10,
          "unit_price": 6.9,
          "strength_mg": 300.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "DALACIN C 300MG 10 CAPS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "PFIZER",
          "price_egp": 114.0,
          "pack_count": 10,
          "unit_price": 11.4,
          "strength_mg": 300.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "KLENDABIOTICAM 1 % TOP. SOLUTION",
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          "manufacturer": "PANAX PHARMA",
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        {
          "trade_name": "ADCOCLINDACE 10MG/ML TOP. SOL.",
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          "manufacturer": "ARAB DRUG COMPANY (ADCO)",
          "price_egp": 12.0,
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          "strength_mg": 10.0,
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          "exact_form": false,
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        }
      ],
      "condition_id": "acute-sialadenitis"
    }
  ]
}