{ "schema_version": 1, "kind": "condition", "id": "amoebiasis", "name": "Amoebiasis", "category": "infectious", "sources": "Egyptian MOH Tropical Med 2020 · WHO Parasitic Diseases 2021", "review_status": "reviewed", "verified_against": "Egyptian MOH Tropical Med 2020 · Amebiasis - disease-level clinical article (amoebiasis-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 146, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Amebiasis - disease-level clinical article (amoebiasis-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Fulminant amoebic colitis, peritonitis, toxic megacolon, or bowel perforation requires broad-spectrum antibiotics and urgent surgical evaluation." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "amoebiasis" }, { "id": 142, "generic": "Metronidazole", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500-750 mg TID", "adult_duration": "7-10 days", "dose_source": "Egyptian MOH Tropical Med 2020", "rationale": "Tissue amoebicide that kills invasive Entamoeba histolytica trophozoites in the bowel wall and liver; it does not reliably clear luminal cysts, which is why a luminal amoebicide follows it.", "cautions": [ "Follow with luminal amoebicide to eliminate cysts.", "Strictly avoid alcohol and propylene glycol-containing products during treatment and for 3 days (72 hours) after the last dose - Egyptian National Drug Formulary, Antimicrobial 2023.", "Metronidazole causes metallic taste, nausea, and peripheral neuropathy on long use." ], "peds_mgkg_low": 35.0, "peds_mgkg_high": 50.0, "peds_max_mg": 2250.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "Divided TID for 7-10 days", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 350, "high_mg": 500, "capped": false }, { "weight_kg": 20, "low_mg": 700, "high_mg": 1000, "capped": false }, { "weight_kg": 30, "low_mg": 1050, "high_mg": 1500, "capped": false }, { "weight_kg": 40, "low_mg": 1400, "high_mg": 2000, "capped": false } ], "brands": [ { "trade_name": "DUMOZOL 500MG 20 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM > ALPHARMA-DENMARK", "price_egp": 7.0, "pack_count": 20, "unit_price": 0.35, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZOLGUARD 500MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA CO. > UNIPHARMA", "price_egp": 9.0, "pack_count": 20, "unit_price": 0.45, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NITROFECTAZOLE 500 MG 20 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GYPTO PHARMA", "price_egp": 10.5, "pack_count": 20, "unit_price": 0.53, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLAGICURE FORTE 500 MG 20 F.C. TAB", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 23.0, "pack_count": 20, "unit_price": 1.15, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TRICHOGYL 500MG 12 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NASR", "price_egp": 15.0, "pack_count": 12, "unit_price": 1.25, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLAGELLAT FORTE 500MG 20 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 30.0, "pack_count": 20, "unit_price": 1.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GEDAZOLE 500MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JEDCO INT. CO. FOR PHARMACEUTICALS", "price_egp": 34.0, "pack_count": 20, "unit_price": 1.7, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "METROGYPTON 500 MG 20 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GYPTO PHARMA", "price_egp": 34.0, "pack_count": 20, "unit_price": 1.7, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DUMOZOL 125MG/5ML SUSP. 125ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM > ALPHARMA-DENMARK", "price_egp": 5.75, "pack_count": null, "unit_price": null, "strength_mg": 125.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "METROZOLE 125MG/5ML SUSP. 120 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 19.5, "pack_count": null, "unit_price": null, "strength_mg": 125.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "amoebiasis" }, { "id": 143, "generic": "Tinidazole", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "2 g once daily, taken with food", "adult_duration": "3 days for intestinal disease, 5 days for a hepatic abscess", "dose_source": "Egyptian MOH Tropical Med 2020", "rationale": "Nitroimidazole tissue amoebicide with the same mechanism as metronidazole against invasive Entamoeba histolytica, favored in Egyptian practice as a shorter, better-tolerated alternative.", "cautions": [ "Tinidazole is shorter in duration and better tolerated than Metronidazole in Egypt.", "Avoid alcohol during treatment and for 72h after last dose.", "Take with food to minimize GI distress." ], "peds_mgkg_low": 50.0, "peds_mgkg_high": 50.0, "peds_max_mg": 2000.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "Once daily for 3-5 days with food", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 500, "high_mg": 500, "capped": false }, { "weight_kg": 20, "low_mg": 1000, "high_mg": 1000, "capped": false }, { "weight_kg": 30, "low_mg": 1500, "high_mg": 1500, "capped": false }, { "weight_kg": 40, "low_mg": 2000, "high_mg": 2000, "capped": false } ], "brands": [ { "trade_name": "FASIGYN 500 MG 4 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER", "price_egp": 8.35, "pack_count": 4, "unit_price": 2.09, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PROTOZOLE 500 MG 12 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 39.0, "pack_count": 12, "unit_price": 3.25, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "amoebiasis" }, { "id": 144, "generic": "Nitazoxanide", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500 mg BID with food", "adult_duration": "3 days", "dose_source": "Egyptian MOH Tropical Med 2020", "rationale": "Broad-spectrum antiparasitic used as a second-line option for mild-to-moderate amoebic colitis when a nitroimidazole is not suitable.", "cautions": [ "Take with food to maximize absorption.", "May cause bright yellow urine discoloration.", "Nitazoxanide is an effective alternative for mild-to-moderate amoebic colitis." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "100 mg BID (1-3 yrs), 200 mg BID (4-11 yrs) with food for 3 days", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "1 to 3 years", "age_min_months": 12, "age_max_months": 47, "dose_text": "100 mg twice daily with food, for 3 days" }, { "label": "4 to 11 years", "age_min_months": 48, "age_max_months": 143, "dose_text": "200 mg twice daily with food, for 3 days" } ], "peds_doses": null, "brands": [ { "trade_name": "UNINITAPROZAX 500MG 12 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA CO. > UNIPHARMA", "price_egp": 16.0, "pack_count": 12, "unit_price": 1.33, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CRYPTOPER 500MG 30 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > TAG PHARMA", "price_egp": 56.0, "pack_count": 30, "unit_price": 1.87, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "XEROVIRINC 500MG 18 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM", "price_egp": 42.0, "pack_count": 18, "unit_price": 2.33, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PARAZOXANIDE 500 MG 18 CAP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR > PHARMACARE", "price_egp": 63.0, "pack_count": 18, "unit_price": 3.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TRUSTNAL 500 MG 10 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ADWIA", "price_egp": 40.0, "pack_count": 10, "unit_price": 4.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NIT CLEAN 500MG 12 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "WESTERN PHARMACEUTICALS INDUSTRIES > WESTERN PHARMA", "price_egp": 72.0, "pack_count": 12, "unit_price": 6.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CRYPTONAZ 500MG 12 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "COPAD PHARMA", "price_egp": 82.0, "pack_count": 12, "unit_price": 6.83, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NIT CLEAN 500MG 5*6 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "WESTERN PHARMACEUTICALS INDUSTRIES > WESTERN PHARMA", "price_egp": 180.0, "pack_count": 6, "unit_price": 30.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "UNINITAPROZAX 100MG/5ML SUSP. 60ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA CO. > UNIPHARMA", "price_egp": 6.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ZOLIFUTAL 100MG/5ML SUSP. 60 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "FUTURE PHARMACEUTICAL INDUSTRIES (FPI)", "price_egp": 13.5, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "amoebiasis" }, { "id": 145, "generic": "Diloxanide furoate", "line": 1, "is_adjunct": true, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500 mg TID", "adult_duration": "10 days", "dose_source": "Egyptian MOH Tropical Med 2020", "rationale": "Diloxanide furoate is an add-on to clear luminal cysts after tissue treatment, not an alternative.", "cautions": [ "Diloxanide furoate is an essential luminal amoebicide following tissue treatment (metronidazole/tinidazole) to eradicate cysts.", "May cause flatulence, abdominal cramps, and nausea.", "Not recommended in children under 2 years." ], "peds_mgkg_low": 20.0, "peds_mgkg_high": 20.0, "peds_max_mg": 1500.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "Given after metronidazole/tinidazole, not in place of it; 20 mg/kg/day divided in 3 doses for 10 days", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 200, "high_mg": 200, "capped": false }, { "weight_kg": 20, "low_mg": 400, "high_mg": 400, "capped": false }, { "weight_kg": 30, "low_mg": 600, "high_mg": 600, "capped": false }, { "weight_kg": 40, "low_mg": 800, "high_mg": 800, "capped": false } ], "brands": [ { "trade_name": "AMOEBYL 500MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 5.3, "pack_count": 20, "unit_price": 0.27, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FURAMEBE 500MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 7.7, "pack_count": 20, "unit_price": 0.39, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "amoebiasis" } ] }