{
  "schema_version": 1,
  "kind": "condition",
  "id": "androgenetic-alopecia",
  "name": "Androgenetic alopecia (pattern hair loss)",
  "category": "chronic",
  "sources": "BAD Guidelines for Male and Female Pattern Hair Loss · Egyptian National Drug Formulary - Endocrine System 2024 (finasteride monograph) · Regaine 5% Cutaneous Solution SmPC section 4.2 (eMC product 5765)",
  "review_status": "reviewed",
  "verified_against": "Regaine 5% Cutaneous Solution SmPC section 4.2 (eMC product 5765) · Egyptian National Drug Formulary - Endocrine System 2024 (finasteride monograph)",
  "verified_date": "2026-08",
  "treatments": [
    {
      "id": 155,
      "generic": "Minoxidil",
      "line": 1,
      "is_adjunct": false,
      "form": "topical",
      "strength_mg": null,
      "adult_dose": "A dose of 1 ml Regaine for Men Extra Strength Scalp Solution 5% w/v Cutaneous Solution should be applied to the total affected areas of the scalp twice daily (total dosage should not exceed 2 ml).",
      "adult_duration": "long-term (continuous)",
      "dose_source": "Regaine 5% Cutaneous Solution SmPC section 4.2 (eMC product 5765)",
      "rationale": "Topical vasodilator that prolongs the growth phase of hair follicles and increases follicle size in pattern hair loss; the exact mechanism is not fully understood, and any benefit is only maintained with continued use.",
      "cautions": [
        "Initial transient shedding of hair during first 2-6 weeks of treatment is expected.",
        "Must be continued indefinitely; hair loss recurs within 3-4 months of stopping.",
        "Scalp irritation, contact dermatitis, and facial hypertrichosis (especially in women) may occur.",
        "Avoid in patients with scalp inflammation or breakdown.",
        "In women, the 5% strength is licensed as a once-daily foam; the twice-daily 5% solution is the men's regimen. Twice-daily 5% solution in a woman raises the risk of facial hypertrichosis.",
        "Contraindicated during pregnancy or lactation."
      ],
      "peds_mgkg_low": null,
      "peds_mgkg_high": null,
      "peds_max_mg": null,
      "peds_basis": null,
      "peds_unit": null,
      "peds_note": "Not indicated in children under 18 years",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": null,
      "brands": [
        {
          "trade_name": "MINOXIDIL FORTE 5% TOPICAL GEL 60 GM",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "EGPI > PHARMACARE",
          "price_egp": 127.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 60000.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        }
      ],
      "condition_id": "androgenetic-alopecia"
    },
    {
      "id": 156,
      "generic": "Finasteride",
      "line": 1,
      "is_adjunct": false,
      "form": "oral.solid",
      "strength_mg": 1.0,
      "adult_dose": "1 mg once daily (men only)",
      "adult_duration": "Continue for 3-6 months to assess full effect; continuous use is recommended to sustain benefit",
      "dose_source": "Egyptian National Drug Formulary - Endocrine System 2024 (finasteride monograph)",
      "rationale": "Selective 5-alpha reductase inhibitor for male pattern androgenetic alopecia",
      "cautions": [
        "STRICTLY CONTRAINDICATED IN WOMEN OF CHILDBEARING POTENTIAL: pregnant women must not touch crushed/broken tablets (teratogenic risk to male fetus).",
        "There are rare reports of persistent sexual side effects and depression post-discontinuation.",
        "Impotence occurs in >10% of patients; decreased libido and ejaculatory disorders occur in 1-10%."
      ],
      "peds_mgkg_low": null,
      "peds_mgkg_high": null,
      "peds_max_mg": null,
      "peds_basis": null,
      "peds_unit": null,
      "peds_note": "CONTRAINDICATED in children and women",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": null,
      "brands": [
        {
          "trade_name": "PROHAIR 1 MG 30 TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "SIGMA",
          "price_egp": 24.0,
          "pack_count": 30,
          "unit_price": 0.8,
          "strength_mg": 1.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "NOPECIA 1 MG 30 CAPS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "ADWIA",
          "price_egp": 36.0,
          "pack_count": 30,
          "unit_price": 1.2,
          "strength_mg": 1.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        }
      ],
      "condition_id": "androgenetic-alopecia"
    }
  ]
}