{ "schema_version": 1, "kind": "condition", "id": "angina-pectoris", "name": "Stable angina pectoris", "category": "chronic", "sources": "ESC Guidelines for Management of Chronic Coronary Syndromes 2019 · Egyptian National Drug Formulary, cardiovascular 2025, isosorbide-5-mononitrate monograph (printed p. 62) · Glyceryl Trinitrate Spray 400 micrograms/metered dose sublingual spray SmPC section 4.2 (eMC product 674) · Atenolol 50 mg Tablets SmPC section 4.2 (eMC product 14294) · Stable Angina - disease-level clinical article (angina-pectoris-clinical.txt) · Egyptian National Drug Formulary - Cardiovascular · Egyptian National Drug Formulary - Cardiovascular 2024 (clopidogrel monograph) · Egyptian National Drug Formulary - Cardiovascular 2024 (amlodipine monograph, angina pectoris indication) · Egyptian National Drug Formulary - Cardiovascular 2024 (perindopril monograph, stable coronary artery disease) · Egyptian National Drug Formulary - Cardiovascular 2024 (atorvastatin monograph, Dosage Regimen, Secondary prevention of cardiovascular events) · Ezetimibe DailyMed label, SetID 11828685-dc27-42d8-a6ff-f110018207d1, section 2", "review_status": "reviewed", "verified_against": "Egyptian National Drug Formulary, cardiovascular 2025, isosorbide-5-mononitrate monograph (printed p. 62) · Glyceryl Trinitrate Spray 400 micrograms/metered dose sublingual spray SmPC section 4.2 (eMC product 674) · Atenolol 50 mg Tablets SmPC section 4.2 (eMC product 14294) · Stable Angina - disease-level clinical article (angina-pectoris-clinical.txt) · Egyptian National Drug Formulary - Cardiovascular · Egyptian National Drug Formulary - Cardiovascular 2024 (clopidogrel monograph) · Egyptian National Drug Formulary - Cardiovascular 2024 (amlodipine monograph, angina pectoris indication) · Egyptian National Drug Formulary - Cardiovascular 2024 (perindopril monograph, stable coronary artery disease) · Egyptian National Drug Formulary - Cardiovascular 2024 (atorvastatin monograph, Dosage Regimen, Secondary prevention of cardiovascular events)", "verified_date": "2026-08", "treatments": [ { "id": 157, "generic": "Glyceryl trinitrate", "line": 1, "is_adjunct": false, "form": "spray", "strength_mg": 0.4, "adult_dose": "At the onset of an attack: one or two metered sprays (400 to 800 micrograms) to be sprayed under the tongue while holding breath. May be repeated at five-minute intervals for a total of three sprays (maximum 1.2 mg within 15 minutes).", "adult_duration": null, "dose_source": "Glyceryl Trinitrate Spray 400 micrograms/metered dose sublingual spray SmPC section 4.2 (eMC product 674)", "rationale": "No sublingual glyceryl trinitrate tablet is registered in Egypt. The spray is the only rapid-onset form on sale - the sustained-release capsules are for prevention and will not stop an attack.", "cautions": [ "If the pain has not gone after three sprays in 15 minutes, this is a suspected myocardial infarction. Call for emergency transfer.", "One or two sprays 2-3 minutes before exertion prevents predictable effort angina.", "Contraindicated with sildenafil, tadalafil or vardenafil - the combination drops blood pressure catastrophically.", "Sit down before using it. Hypotension, dizziness and headache are common." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not for use under 18 years.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "NITROLINGUAL 0.4MG/DOSE ORAL SPRAY", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "G.POHL BOSKAMP - GERMANY > SUNNY MEDICAL", "price_egp": 30.0, "pack_count": null, "unit_price": null, "strength_mg": 0.4, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "angina-pectoris" }, { "id": 160, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Stable Angina - disease-level clinical article (angina-pectoris-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - The warning signs that mean this is no longer stable angina and needs urgent escalation are chest pain at rest, pain lasting longer than 15-20 minutes, or pain not relieved by nitrates (suggesting unstable angina/ACS)." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "angina-pectoris" }, { "id": 161, "generic": "Atorvastatin", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 80.0, "adult_dose": "80 mg once daily", "adult_duration": null, "dose_source": "Egyptian National Drug Formulary - Cardiovascular 2024 (atorvastatin monograph, Dosage Regimen, Secondary prevention of cardiovascular events)", "rationale": "High-intensity statin therapy for secondary prevention in stable coronary artery disease. Reviewed in August 2026: the 80 mg sits inside the article's high-intensity band and is the Egyptian formulary's own figure for this indication, so the card's statin coverage was already adequate and no dose changed. What was wrong was the citation - it named the Egyptian National Drug Formulary's cardiovascular volume with no year, no monograph and no section, so it could not be re-found.", "cautions": [ "CONTRAINDICATED where the patient is hypersensitive to atorvastatin or to any of the product's other ingredients; in acute liver failure or decompensated cirrhosis; and in pregnancy or while breast-feeding.", "The dose is the formulary's own for this indication - 80 mg once daily for secondary prevention of a cardiovascular event, filed under its heading for preventing atherosclerotic cardiovascular disease.", "The article asks for the same intensity - a high-intensity statin for everyone with chronic coronary syndrome, meaning atorvastatin at 40–80 mg or rosuvastatin at 20–40 mg, with the target a fall in LDL-C of 50% or more.", "The formulary's own caveat at this dose: a patient taking atorvastatin 80 mg a day sits at high risk of haemorrhagic stroke - which matters in anyone with a previous intracerebral bleed.", "Stop it in pregnancy and while breastfeeding; a woman of childbearing age on 80 mg needs that said plainly." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Children ≥10 years (familial hypercholesterolemia): Initially 10 mg once daily, increased to 40 mg once daily at intervals of at least 4 weeks; maximum 80 mg per day.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "10 years and over", "age_min_months": 120, "age_max_months": 216, "dose_text": "For familial hypercholesterolaemia: initially 10 mg once daily, increased to 40 mg once daily at intervals of at least 4 weeks; maximum 80 mg per day." } ], "peds_doses": null, "brands": [ { "trade_name": "LIRIMAR 80 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RIVA PHARMA S.A.E.", "price_egp": 29.0, "pack_count": 10, "unit_price": 2.9, "strength_mg": 80.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ADROBEGA 80MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEDIZEN PHARMACEUTICAL INDUSTRIES > ROYAL GROUP", "price_egp": 31.2, "pack_count": 10, "unit_price": 3.12, "strength_mg": 80.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VONTEROID 80MG 7 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA > LMCO PHARMA-EGYPT", "price_egp": 28.0, "pack_count": 7, "unit_price": 4.0, "strength_mg": 80.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ATOR 80 MG 10 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 112.0, "pack_count": 10, "unit_price": 11.2, "strength_mg": 80.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LIPITOR 80 MG 14 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER > VIATRIS EGYPT", "price_egp": 236.0, "pack_count": 14, "unit_price": 16.86, "strength_mg": 80.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LIPITOR 80 MG 7 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER > VIATRIS EGYPT", "price_egp": 118.0, "pack_count": 7, "unit_price": 16.86, "strength_mg": 80.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ATORSTAT 80MG 10 BISCORED TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DELTA PHARMA", "price_egp": 64.0, "pack_count": null, "unit_price": null, "strength_mg": 80.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CHOLESTGLOB 80 MG 20 SCORED F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ATCO PHARMA > CHAMPIONS PHARMA (PAS)", "price_egp": 89.66, "pack_count": null, "unit_price": null, "strength_mg": 80.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "angina-pectoris" }, { "id": 163, "generic": "Acetylsalicylic acid", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": null, "adult_dose": "75 to 162 mg once daily, in every patient with stable angina.", "adult_duration": "lifelong", "dose_source": "Stable angina pectoris - disease-level clinical article (angina-pectoris-clinical.txt) for the indication and the adult dose; the paediatric band above is from Egyptian National Drug Formulary - Cardiovascular 2024 (acetylsalicylic acid monograph): \"Child 1 month-11 years: 1-5 mg/kg once daily (max. per dose 75 mg); Child 12-17 years: 75 mg once daily\", given there for antiplatelet prevention of thrombus formation after cardiac surgery - not for this indication.", "rationale": "Lifelong antiplatelet therapy to reduce risk of myocardial infarction, stroke, and death in patients with stable angina.", "cautions": [ "Increased risk of gastrointestinal bleeding.", "Contraindicated in active peptic ulceration or severe aspirin hypersensitivity." ], "peds_mgkg_low": 1.0, "peds_mgkg_high": 5.0, "peds_max_mg": 75.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "Child 1 month-11 years: 1-5 mg/kg once daily, no single dose above 75 mg; Child 12-17 years: 75 mg once daily. The article cited here is adult-only and states no paediatric dose - it gives aspirin as 75 mg to 162 mg once daily, lifelong, in all patients with stable angina. Stable angina in a child is not a primary-care diagnosis: it points to congenital or acquired coronary disease, and needs paediatric cardiology.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "1 month to 11 years", "age_min_months": 1, "age_max_months": 143, "dose_text": "1 to 5 mg/kg once daily, maximum 75 mg per dose" }, { "label": "12 to 17 years", "age_min_months": 144, "age_max_months": 215, "dose_text": "75 mg once daily" } ], "peds_doses": [ { "weight_kg": 10, "low_mg": 10, "high_mg": 50, "capped": false }, { "weight_kg": 20, "low_mg": 20, "high_mg": 75, "capped": true }, { "weight_kg": 30, "low_mg": 30, "high_mg": 75, "capped": true }, { "weight_kg": 40, "low_mg": 40, "high_mg": 75, "capped": true } ], "brands": [ { "trade_name": "ASPOCID 300 MG 200 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 80.0, "pack_count": 200, "unit_price": 0.4, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AGGREX 75MG 60 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA", "price_egp": 33.0, "pack_count": 60, "unit_price": 0.55, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ASPOCID 75MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 22.0, "pack_count": 20, "unit_price": 1.1, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ECOPRIN 325MG 10 ENTERIC COATED TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 5.0, "pack_count": null, "unit_price": null, "strength_mg": 325.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RIVO 75 MG 30 CHEW. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 21.0, "pack_count": null, "unit_price": null, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ASPRICARLO 81MG 30 CHEWABLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EUROPEAN EGYPTIAN PHARM. IND.", "price_egp": 45.0, "pack_count": null, "unit_price": null, "strength_mg": 81.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ASPIRIN PROTECT 100 MG 30 GASTRO-RESISTANT TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS > BAYER BITTERFELD GMBH-GERMANY", "price_egp": 78.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "JUSPRIN 81 MG 60 E.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "FUTURE PHARMACEUTICAL INDUSTRIES (FPI) > JULPHAR", "price_egp": 81.0, "pack_count": null, "unit_price": null, "strength_mg": 81.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "angina-pectoris" }, { "id": 164, "generic": "Clopidogrel", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 75.0, "adult_dose": "75 mg once daily", "adult_duration": "Lifelong", "dose_source": "Egyptian National Drug Formulary - Cardiovascular 2024 (clopidogrel monograph)", "rationale": "The disease article puts every stable angina patient on lifelong antiplatelet therapy, with clopidogrel for the aspirin-intolerant. Aspirin is already on the card and keeps its place; this is the alternative for those who cannot take it.", "cautions": [ "Hypersensitivity (eg, anaphylaxis) to clopidogrel or any component of the formulation", "Active pathological bleeding (eg, peptic ulcer, intracranial haemorrhage)", "Significant liver impairment or cholestatic jaundice", "The ENDF states this 75 mg once daily dose for myocardial infarction, ischaemic stroke or peripheral atherosclerotic disease; the chronic stable angina indication comes from the disease article.", "Not to be taken together with aspirin here - this row is the alternative for the aspirin-intolerant patient, not an addition to it." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "The ENDF clopidogrel monograph gives no paediatric dose, so none is stated here.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "BLOTAGRIL 75MG 30 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEDIZEN PHARMACEUTICAL INDUSTRIES", "price_egp": 33.0, "pack_count": 30, "unit_price": 1.1, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ITOLAVIX 75 MG 30 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA > INTERNATIONAL TRADING OFFICE", "price_egp": 54.0, "pack_count": 30, "unit_price": 1.8, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BORGAVIX 75MG 30 F.C. TABLETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "BORG", "price_egp": 66.0, "pack_count": 30, "unit_price": 2.2, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SIGAGREL 75MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 30.0, "pack_count": 10, "unit_price": 3.0, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLOPACIRC 75 MG 30 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "COPAD PHARMA", "price_egp": 117.0, "pack_count": 30, "unit_price": 3.9, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "THROMBO 75MG 30 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 123.0, "pack_count": 30, "unit_price": 4.1, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PLATENOR 75MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HI-PHARM > EGYPHARMA-EGYPT", "price_egp": 150.0, "pack_count": 30, "unit_price": 5.0, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PLAVIX 75 MG 28 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI WINTHROP > SANOFI", "price_egp": 311.0, "pack_count": 28, "unit_price": 11.11, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "angina-pectoris" }, { "id": 158, "generic": "Isosorbide-5-mononitrate", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 20.0, "adult_dose": "20 mg twice daily, the two doses 7 hours apart (e.g. 08:00 and 15:00) to leave a nitrate-free interval", "adult_duration": null, "dose_source": "Egyptian National Drug Formulary, cardiovascular 2025, isosorbide-5-mononitrate monograph (printed p. 62)", "rationale": "Long-acting nitrate that dilates veins and coronary arteries, lowering cardiac preload and oxygen demand to relieve and prevent anginal chest pain; its benefit depends on preserving the nitrate-free interval set out in the cautions, without which tolerance develops.", "cautions": [ "Asymmetrical dosing, 7 hours apart (e.g. 08:00 and 15:00), is what stops tolerance developing - even spacing does not.", "May cause severe headache initially.", "Contraindicated with phosphodiesterase-5 inhibitors (sildenafil, tadalafil)." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not indicated in children", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "ISOSORBIDE 20MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 3.0, "pack_count": 10, "unit_price": 0.3, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CARDIOGUARD M 20MG SR 10CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMOUN", "price_egp": 6.0, "pack_count": 10, "unit_price": 0.6, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MONOMAK 20MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "OCTOBER PHARMA", "price_egp": 28.0, "pack_count": 20, "unit_price": 1.4, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANGIOFOX (EFFOX) 20 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM", "price_egp": 46.0, "pack_count": 20, "unit_price": 2.3, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "angina-pectoris" }, { "id": 159, "generic": "Atenolol", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 50.0, "adult_dose": "100 mg once daily, or 50 mg twice daily. Increasing beyond this is unlikely to add benefit", "adult_duration": null, "dose_source": "Atenolol 50 mg Tablets SmPC section 4.2 (eMC product 14294)", "rationale": "18 live products and one of the cheapest antianginals on the Egyptian market. The formulary lists long-term management of angina pectoris as a named indication with a clean once-daily dose.", "cautions": [ "Use one beta-blocker only - atenolol is an alternative to the bisoprolol in this row, not an addition.", "CONTRAINDICATED in uncompensated heart failure, heart block above first degree, cardiogenic shock, severe peripheral arterial disease and untreated phaeochromocytoma.", "Never stop abruptly - rebound angina and myocardial infarction are reported; taper over 1-2 weeks.", "Masks the warning signs of hypoglycaemia in insulin-treated diabetes.", "Atenolol is less effective than other beta-blockers at preventing stroke when used purely as an antihypertensive - it earns its place here for angina, not for blood pressure.", "Reduce in renal impairment: 50 mg daily if creatinine clearance is 15-35 mL/min/1.73m2, and 25 mg daily or 50 mg on alternate days below 15." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not recommended in children - the label states there is no paediatric experience with atenolol.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "AMOTENOLOL 50MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMOUN", "price_egp": 3.0, "pack_count": 10, "unit_price": 0.3, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ATENOLOL 50MG 20 TAB. BP 2000", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JEDCO INT. CO. FOR PHARMACEUTICALS", "price_egp": 6.25, "pack_count": 20, "unit_price": 0.31, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ATELOL 50MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 7.5, "pack_count": 20, "unit_price": 0.38, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BLOKIUM 50 MG 15 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP > ALMIRALL PRODES-SPAIN", "price_egp": 7.0, "pack_count": 15, "unit_price": 0.47, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TENOTENS 50MG 14 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 8.0, "pack_count": 14, "unit_price": 0.57, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ATENO 50MG 20 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 20.0, "pack_count": 20, "unit_price": 1.0, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TENORMIN 50MG 28 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ASTRA ZENECA", "price_egp": 42.0, "pack_count": 28, "unit_price": 1.5, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BETENVAC 0.5% SYRUP 100ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA > PHARMA VISION", "price_egp": 22.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "SWABILOL 25MG/5ML 20 UNIDOSE ORAL SOLN.* 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNISWAB", "price_egp": 50.0, "pack_count": null, "unit_price": null, "strength_mg": 25.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "angina-pectoris" }, { "id": 162, "generic": "Nicorandil", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 10.0, "adult_dose": "Initially 5–10 mg twice daily, then increased if necessary and tolerated up to 40 mg twice daily.", "adult_duration": null, "dose_source": "Egyptian National Drug Formulary - Cardiovascular", "rationale": "Second-line potassium-channel opener antianginal agent for patients with stable angina.", "cautions": [ "Hypovolaemia or severe hypotension", "Nicorandil may cause serious ulcers at skin, mucosa, and eye; including GIT ulcers, which may progress to perforation, hemorrhage, fistula or abscess." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not recommended for pediatric patients.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "DILIKORELL 10 MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HIKMA PHARMA", "price_egp": 7.0, "pack_count": 10, "unit_price": 0.7, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RANDIL 10MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ADWIA", "price_egp": 66.0, "pack_count": 30, "unit_price": 2.2, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANGILOW 10 MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ADWIA > TABUK PHARMA", "price_egp": 87.0, "pack_count": 30, "unit_price": 2.9, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ADANCOR 10MG 30 BREAKABLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MERCK KGAA F.R.GERMANY > MERCK LIMITED EGYPT", "price_egp": 83.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "angina-pectoris" }, { "id": 165, "generic": "Amlodipine", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 5.0, "adult_dose": "5 to 10 mg once daily", "adult_duration": null, "dose_source": "Egyptian National Drug Formulary - Cardiovascular 2024 (amlodipine monograph, angina pectoris indication)", "rationale": "The disease article names a calcium channel blocker as the alternative for symptom control when a beta-blocker is contraindicated, not tolerated, or insufficient - for example in reactive airway disease. The card offered atenolol alone. The ENDF gives amlodipine an explicit chronic stable angina dose.", "cautions": [ "Hypersensitivity to amlodipine or any component of the formulation", "The ENDF names amlodipine an alternative agent for chronic stable angina; it does not displace the beta-blocker as the article's first choice for symptom control." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "The ENDF gives a paediatric amlodipine dose for hypertension only (children 6 years and over, initial 2.5 mg once daily, maximum 10 mg/day) and none for angina, so no paediatric angina figure is stated here.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "CORONAVINE 5 MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 6.0, "pack_count": 10, "unit_price": 0.6, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "WINDIPINE 5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 21.0, "pack_count": 30, "unit_price": 0.7, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VASOPINE 5 MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 24.0, "pack_count": 30, "unit_price": 0.8, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AMILO 5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALFACURE PHARMACEUTICALS", "price_egp": 54.0, "pack_count": 30, "unit_price": 1.8, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AMLODIPINE 5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 60.0, "pack_count": 30, "unit_price": 2.0, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MYODURA 5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS > WOCKHARDT", "price_egp": 69.0, "pack_count": 30, "unit_price": 2.3, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NORVASC 5MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER > VIATRIS EGYPT", "price_egp": 54.0, "pack_count": 10, "unit_price": 5.4, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NORVASC 5MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER > VIATRIS EGYPT", "price_egp": 162.0, "pack_count": 30, "unit_price": 5.4, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "angina-pectoris" }, { "id": 166, "generic": "Perindopril", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 5.0, "adult_dose": "Perindopril arginine 5 mg once daily (2.5 mg in the elderly) for 2 weeks, then increased as tolerated to 10 mg once daily; perindopril erbumine 4 mg once daily (2 mg in the elderly) for 2 weeks, then increased as tolerated to 8 mg once daily", "adult_duration": null, "dose_source": "Egyptian National Drug Formulary - Cardiovascular 2024 (perindopril monograph, stable coronary artery disease)", "rationale": "The article recommends an ACE inhibitor or ARB in stable angina, particularly with coexisting hypertension, left ventricular dysfunction, diabetes or chronic kidney disease, but names no agent. Perindopril is the one the ENDF names for this exact condition - it carries a separate stable coronary artery disease indication and a dose written for it, rather than the hypertension dose borrowed.", "cautions": [ "Angiotensin-converting enzyme inhibitors (ACE inhibitors) hypersensitivity", "History of angioedema", "Do not combine with aliskiren in patients with diabetes mellitus or moderate to severe kidney impairment, and not within 36 hours of a neprilysin inhibitor.", "Dose is reduced in renal impairment: perindopril erbumine, CrCl 30 to 80 mL/minute, initial 2 mg/day with a maximum maintenance dose of 8 mg/day." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not applicable - stable angina is an adult disease and the ENDF gives no paediatric perindopril dose.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "COVERSYL 5MG 30 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SERVIER", "price_egp": 79.0, "pack_count": 30, "unit_price": 2.63, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "COVERSYL 5MG 15 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SERVIER", "price_egp": 40.0, "pack_count": 15, "unit_price": 2.67, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "angina-pectoris" }, { "id": 167, "generic": "Ezetimibe", "line": 2, "is_adjunct": true, "form": "oral.solid", "strength_mg": 10.0, "adult_dose": "10 mg once daily, with or without food", "adult_duration": null, "dose_source": "Ezetimibe DailyMed label, SetID 11828685-dc27-42d8-a6ff-f110018207d1, section 2 - verbatim: \"The recommended dose of ezetimibe tablets is 10 mg orally once daily, administered with or without food.\"", "rationale": "The card stops at high-dose atorvastatin, so it has no answer for the common case where the cholesterol is still too high on a maximal statin. This is the article's next step and a GP can add it.", "cautions": [ "It is an add-on to the statin, not a replacement for it - do not swap a statin for ezetimibe because of muscle aches without reviewing the statin first.", "If the statin it is combined with is contraindicated, so is the combination.", "Recheck the lipid profile a few weeks after starting it rather than assuming it worked." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "No paediatric dose for this indication in the sources opened.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "LOWTIMIB 10 MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 11.5, "pack_count": 10, "unit_price": 1.15, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CHOLSTOP 10MG 30 TAB", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 41.0, "pack_count": 30, "unit_price": 1.37, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EZETIMIBE 10MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "BORG", "price_egp": 14.4, "pack_count": 10, "unit_price": 1.44, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LIPIDNORM 10 MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "OCTOBER PHARMA", "price_egp": 14.4, "pack_count": 10, "unit_price": 1.44, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZETAMIBE 10 MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ADWIA", "price_egp": 34.8, "pack_count": 10, "unit_price": 3.48, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZETLIP 10MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "BIORIGINAL INTERNATIONAL GROUP PHARMA EGYPT", "price_egp": 35.0, "pack_count": 10, "unit_price": 3.5, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CHOLETIMB 10 MG 14 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MARCYRL PHARMACEUTICAL INDUSTRIES (MPI)", "price_egp": 65.0, "pack_count": 14, "unit_price": 4.64, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EZETROL 10MG 7 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MERCK SHARP & DOHME > GLOBAL NAPI PHARMACEUTICALS", "price_egp": 90.0, "pack_count": 7, "unit_price": 12.86, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "angina-pectoris" } ] }