{ "schema_version": 1, "kind": "condition", "id": "angioedema", "name": "Acute allergic angioedema", "category": "chronic", "sources": "Resuscitation Council UK Anaphylaxis Guideline 2021 · Egyptian National Drug Formulary - Respiratory System 2026 (cetirizine monograph)", "review_status": "reviewed", "verified_against": "Resuscitation Council UK Anaphylaxis Guideline 2021 · Egyptian National Drug Formulary - Respiratory System 2026 (cetirizine monograph) · Acute allergic angioedema - disease-level clinical article (angioedema-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 168, "generic": "Adrenaline", "line": 1, "is_adjunct": false, "form": "injection", "strength_mg": 1.0, "adult_dose": "0.5 mg IM (0.5 mL of 1:1000 / 1 mg/mL) into anterolateral mid-thigh; repeat after 5 minutes if airway involvement or hypotension persists", "adult_duration": "single dose", "dose_source": "Resuscitation Council UK Anaphylaxis Guideline 2021", "rationale": "First-line life-saving treatment for acute allergic angioedema with airway compromise or anaphylaxis", "cautions": [ "MUST be given intramuscularly (IM) into mid-outer thigh, NOT intravenously (IV injection carries fatal cardiac arrhythmia risk).", "Call emergency services immediately for hospital transport.", "Transient pallor, tremor, palpitations, and anxiety are expected pharmacological effects." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Child: 0.01 mg/kg (0.01 mL/kg of 1:1000) IM into outer thigh (child <6y: 0.15 mg; 6-12y: 0.3 mg; >12y: 0.5 mg)", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "EPINEPHRINE-MEMPHIS 1 MG/ML 5 I.M./S.C. AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 10.0, "pack_count": null, "unit_price": null, "strength_mg": 1.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ADRENAMAX 1 MG/1ML 10 AMPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CHEMIPHARM", "price_egp": 75.0, "pack_count": null, "unit_price": null, "strength_mg": 1.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EPINEPHRINE-MISR 1 MG/ML 100 AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR", "price_egp": 750.0, "pack_count": null, "unit_price": null, "strength_mg": 1.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ADRENALINE-CID 1 MG/1ML 100 I.M./S.C. AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 850.0, "pack_count": null, "unit_price": null, "strength_mg": 1.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "angioedema" }, { "id": 171, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Angioedema - disease-level clinical article (angioedema-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Laryngeal/airway involvement makes angioedema life-threatening. Airway compromise needs urgent airway management and hospital referral (intubation or surgical airway), not simply a repeat adrenaline dose at 5 minutes.", "RED FLAG - If the episode does not respond to epinephrine, an antihistamine and a corticosteroid, that itself is a red flag for bradykinin-mediated angioedema (e.g. ACE-inhibitor-induced or hereditary), which needs a different approach: stop the ACE inhibitor and never rechallenge, and refer for bradykinin-targeted therapy." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "angioedema" }, { "id": 169, "generic": "Cetirizine", "line": 1, "is_adjunct": true, "form": "oral.solid", "strength_mg": 10.0, "adult_dose": "10 mg once daily oral (or chlorphenamine 10 mg slow IV/IM in emergency setting)", "adult_duration": "3-5 days", "dose_source": "Egyptian National Drug Formulary - Respiratory System 2026 (cetirizine monograph)", "rationale": "Secondary adjunctive therapy after adrenaline", "cautions": [ "Antihistamines DO NOT treat or prevent laryngeal edema or anaphylactic shock; adrenaline must be given first." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Child 2-5 years: 2.5 mg twice daily; 6-11 years: 5 mg twice daily; >=12 years: 10 mg once daily", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "2 to under 6 years", "age_min_months": 24, "age_max_months": 71, "dose_text": "2.5 mg twice daily" }, { "label": "6 to under 12 years", "age_min_months": 72, "age_max_months": 143, "dose_text": "5 mg twice daily" }, { "label": "12 years and over", "age_min_months": 144, "age_max_months": 216, "dose_text": "10 mg once daily" } ], "peds_doses": null, "brands": [ { "trade_name": "EPIRIZINE 10 MG 10 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 15.5, "pack_count": 10, "unit_price": 1.55, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CETRITIN 10MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 42.0, "pack_count": 20, "unit_price": 2.1, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TOMAZINE 10MG 30 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALFACURE PHARMACEUTICALS", "price_egp": 63.0, "pack_count": 30, "unit_price": 2.1, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CETRAK 10 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 68.0, "pack_count": 20, "unit_price": 3.4, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HISTAZINE-1 10 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 68.0, "pack_count": 20, "unit_price": 3.4, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZYRTEC 10 MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE", "price_egp": 100.0, "pack_count": 20, "unit_price": 5.0, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CETRICHEW 10MG 20 CHEWABLE F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AL ROWAD PHARMACEUTICAL INDUSTRIAL CO.", "price_egp": 15.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HISTA CHEW 10 MG 20 CHEWABLE TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB CAPS > ADVOCURE", "price_egp": 15.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LERGFREE 5MG/5ML SYRUP 120ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DEBEIKY", "price_egp": 9.0, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "EPIRIZINE 5MG/ML SYRUP 60 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 19.0, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "angioedema" }, { "id": 170, "generic": "Hydrocortisone", "line": 1, "is_adjunct": true, "form": "injection", "strength_mg": 100.0, "adult_dose": "200 mg slow IV or IM (or Prednisolone 40-50 mg orally)", "adult_duration": "single dose", "dose_source": "Resuscitation Council UK Anaphylaxis Guideline 2021", "rationale": "Adjunctive therapy to prevent biphasic late-phase allergic reaction", "cautions": [ "Delayed onset of action (4-6 hours); never rely on corticosteroids for immediate airway relief." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Child: 2-4 mg/kg IV/IM (max 100 mg for <6 yrs, 200 mg for >=6 yrs)", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "SOLU-CORTEF 100MG/2ML VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO > PFIZER", "price_egp": 16.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HYDROCORTISONE SODIUM SUCCINATE 100MG I.V./I.M.VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 26.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "angioedema" } ] }