{ "schema_version": 1, "kind": "condition", "id": "burning-mouth-tongue", "name": "Burning Mouth or Tongue (Glossodynia)", "category": "chronic", "sources": "Clonazepam tablets US prescribing information, DESCRIPTION and DOSAGE AND ADMINISTRATION (DailyMed SetID 30d674f9-f1b3-4c2d-a8e9-3bc8e476f1ec, Advagen Pharma): \"available as scored tablet with debossing containing 0.5 mg of clonazepam\". The label's own starting dose is for seizure disorders - \"The initial dose for adults with seizure disorders should not exceed 1.5 mg/day divided into three doses\" - so 0.5 mg daily is a third of that, and the label carries no burning-mouth indication. · Burning Mouth Syndrome - StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK519529/ · ICPC-3 (WONCA International Classification of Primary Care, 3rd edition) class DS20.01 - condition scope only, no dose · No dose - referral pathway, no medicine given in primary care", "review_status": "reviewed", "verified_against": "Clonazepam tablets US prescribing information, DESCRIPTION and DOSAGE AND ADMINISTRATION (DailyMed SetID 30d674f9-f1b3-4c2d-a8e9-3bc8e476f1ec, Advagen Pharma): \"available as scored tablet with debossing containing 0.5 mg of clonazepam\". The label's own starting dose is for seizure disorders - \"The initial dose for adults with seizure disorders should not exceed 1.5 mg/day divided into three doses\" - so 0.5 mg daily is a third of that, and the label carries no burning-mouth indication. · No dose - referral pathway, no medicine given in primary care · Burning Mouth or Tongue (Glossodynia) - disease-level clinical article (burning-mouth-tongue-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 327, "generic": "No drug therapy in primary care (Referral & Advice)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": "A burning sensation of the tongue or mouth; a GP screens for treatable causes such as vitamin deficiency, oral thrush or diabetes and treats those directly, referring persistent cases with no identified cause.", "adult_duration": "Refer, with advice", "dose_source": "No dose - referral pathway, no medicine given in primary care", "rationale": "A burning sensation of the tongue or mouth; a GP screens for treatable causes such as vitamin deficiency, oral thrush or diabetes and treats those directly, referring persistent cases with no identified cause.", "cautions": [ "RED FLAG - Unintentional weight loss or persistent mucosal bleeding: assess urgently and refer.", "RED FLAG - Progressive dysphagia or odynophagia: assess urgently and refer.", "RED FLAG - Unexplained oral mucosal ulceration or erythroplakia/leukoplakia: assess urgently and refer.", "No medicine is prescribed for this in primary care - this entry is for recognition and referral. Anything given is decided by the service it is referred to.", "Look for visible white patches, which suggest oral candidiasis, and for signs of anaemia or nutritional deficiency. Refer for specialist evaluation when symptoms persist despite treating the reversible causes." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Children follow the same pathway: recognise and refer. No primary-care medicine is implied.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "burning-mouth-tongue" }, { "id": 328, "generic": "Clonazepam", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": null, "adult_dose": "0.5 mg per day", "adult_duration": null, "dose_source": "Clonazepam tablets US prescribing information, DESCRIPTION and DOSAGE AND ADMINISTRATION (DailyMed SetID 30d674f9-f1b3-4c2d-a8e9-3bc8e476f1ec, Advagen Pharma): \"available as scored tablet with debossing containing 0.5 mg of clonazepam\". The label's own starting dose is for seizure disorders - \"The initial dose for adults with seizure disorders should not exceed 1.5 mg/day divided into three doses\" - so 0.5 mg daily is a third of that, and the label carries no burning-mouth indication.", "rationale": "Low-dose systemic clonazepam for treating burning mouth syndrome pain after excluding secondary organic causes.", "cautions": [ "Clonazepam is a benzodiazepine: sedation, cognitive impairment, and physical dependence are risks.", "Avoid alcohol and driving.", "The formulary doses clonazepam systemically for seizures and panic. Sucking a tablet for local effect in burning mouth syndrome is an off-label use of the tablet and is not a dose the formulary gives." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "No paediatric dose is stated in the sources held for this drug.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "RONATRIL 0.5MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HI-PHARM", "price_egp": 1.75, "pack_count": 10, "unit_price": 0.17, "strength_mg": 0.5, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SIGOTRYL 0.5MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 1.75, "pack_count": 10, "unit_price": 0.17, "strength_mg": 0.5, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RONATRIL 2MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HI-PHARM", "price_egp": 9.5, "pack_count": 30, "unit_price": 0.32, "strength_mg": 2.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AMOTRIL 0.5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMOUN", "price_egp": 16.5, "pack_count": 30, "unit_price": 0.55, "strength_mg": 0.5, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "APETRYL 0.5 MG 50 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MULTI-APEX", "price_egp": 45.0, "pack_count": 50, "unit_price": 0.9, "strength_mg": 0.5, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLOPAM 2MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 30.0, "pack_count": 30, "unit_price": 1.0, "strength_mg": 2.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "APETRYL 2 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MULTI-APEX", "price_egp": 45.0, "pack_count": 30, "unit_price": 1.5, "strength_mg": 2.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "KLOZEPAM 2 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 32.0, "pack_count": 20, "unit_price": 1.6, "strength_mg": 2.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "KLOZEPAM 2.5MG/ML 15ML ORAL DROPS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 40.0, "pack_count": null, "unit_price": null, "strength_mg": 2.5, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "RIVOTRIL 2.5MG/ML ORAL DROPS 10ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "F.HOFFMAN LA ROCHE > EGYPTIAN PHARMACEUTICAL TRADING COMPANY", "price_egp": 87.0, "pack_count": null, "unit_price": null, "strength_mg": 2.5, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "burning-mouth-tongue" } ] }