{ "schema_version": 1, "kind": "condition", "id": "campylobacter-infection", "name": "Campylobacter Infection", "category": "acute", "sources": "Egyptian National Drug Formulary - Antimicrobial 2023, Azithromycin monograph, PDF page index 267-268 (printed p258-259), \"General dosing, susceptible infection\". Note: this monograph lists no shigellosis or campylobacter indication - the dose shown is the formulary's general azithromycin course, not an indication-matched regimen. If the project requires indication-matched sourcing, this row needs a WHO or CDC diarrhoeal-disease citation instead. · Egyptian National Drug Formulary - Antimicrobial 2023, Ciprofloxacin monograph, PDF page index 373-374 (printed p364-365). The formulary lists \"infectious diarrhea\" as an adult indication but attaches no dose to it; the 500 mg every 12 hours figure is taken from its nontyphoidal Salmonella GI regimen. There is no shigellosis, campylobacter or Yersinia enterocolitica regimen in this monograph. · WHO. The treatment of diarrhoea: a manual for physicians and other senior health workers, 4th rev. Geneva: WHO; 2005 (IRIS 10665/43209), section 4.3.1 and Table 2", "review_status": "reviewed", "verified_against": "Egyptian National Drug Formulary - Antimicrobial 2023, Azithromycin monograph, PDF page index 267-268 (printed p258-259), \"General dosing, susceptible infection\". Note: this monograph lists no shigellosis or campylobacter indication - the dose shown is the formulary's general azithromycin course, not an indication-matched regimen. · Egyptian National Drug Formulary - Antimicrobial 2023, Ciprofloxacin monograph, PDF page index 373-374 (printed p364-365). The formulary lists \"infectious diarrhea\" as an adult indication but attaches no dose to it; the 500 mg every 12 hours figure is taken from its nontyphoidal Salmonella GI regimen. There is no shigellosis, campylobacter or Yersinia enterocolitica regimen in this monograph. · WHO. The treatment of diarrhoea: a manual for physicians and other senior health workers, 4th rev. Geneva: WHO; 2005 (IRIS 10665/43209), section 4.3.1 and Table 2 · Campylobacter Infection - disease-level clinical article (campylobacter-infection-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 341, "generic": "ORS", "line": 1, "is_adjunct": false, "form": "oral.solution", "strength_mg": null, "adult_dose": "Plan A (no dehydration): Drink as much ORS solution / fluid as desired after each loose stool. Plan B (some dehydration): 2,200 to 4,000 mL of ORS solution over the first 4 hours (up to 750 mL/hour), then reassess.", "adult_duration": "Until diarrhoea stops", "dose_source": "WHO. The treatment of diarrhoea: a manual for physicians and other senior health workers, 4th rev. Geneva: WHO; 2005 (IRIS 10665/43209), section 4.3.1 and Table 2", "rationale": "Standard oral rehydration regimen for infectious diarrhoea of any bacterial cause; Campylobacter causes typical, not cholera-scale, fluid loss.", "cautions": [ "Mainstay of treatment for essentially all patients regardless of whether antibiotics are also given.", "Assess and correct dehydration first; use the higher-volume cholera regimen only if profuse watery ('rice-water') stool suggests cholera instead.", "Continue feeding/breastfeeding in children alongside ORS.", "Reassess or refer for high fever, bloody diarrhoea, signs of dehydration, symptoms lasting more than a week, or an immunocompromised patient." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Plan B (some dehydration): give the child's weight in kg x 75 mL of ORS solution in the first 4 hours, then reassess. Plan A (no dehydration): 50-100 mL after each loose stool under 2 years, 100-200 mL from 2 to 10 years.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "Under 2 years", "age_min_months": 0, "age_max_months": 23, "dose_text": "50 to 100 mL of ORS after each loose stool (Plan A, no dehydration). With some dehydration, Plan B is by weight at any age." }, { "label": "2 to 10 years", "age_min_months": 24, "age_max_months": 131, "dose_text": "100 to 200 mL of ORS after each loose stool (Plan A, no dehydration). With some dehydration, Plan B is by weight at any age." } ], "peds_doses": null, "brands": [ { "trade_name": "GLUCOHYDRAN 10 SACHET.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 1.75, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "REHYDRAN N 10 SACHET", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 4.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "REHYDRO ZINC 10 SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ORS 20 SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 40.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ELECTRO MASH SYRUP 200 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 60.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLEXOLYTE ORAL REHYDRATION SOL. 240 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KEMPETRO FOR CHEMICAL INDUSTRIES", "price_egp": 65.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HERO ORS 200 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HERO > HERO MEA TRADING", "price_egp": 120.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SANSO ORS SYRUP 140 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AUG PHARMA", "price_egp": 400.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "campylobacter-infection" }, { "id": 344, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Campylobacter Infection - disease-level clinical article (campylobacter-infection-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Antibiotics are only indicated for high-risk patients (immunocompromised, elderly) or severe disease (fever, bloody stools, severe abdominal pain) - healthy patients get supportive care only.", "RED FLAG - Guillain-Barre syndrome (ascending paralysis) is a delayed post-infectious complication patients should be warned to watch for." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "campylobacter-infection" }, { "id": 342, "generic": "Azithromycin", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500 mg once daily", "adult_duration": "3 days", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023, Azithromycin monograph, PDF page index 267-268 (printed p258-259), \"General dosing, susceptible infection\". Note: this monograph lists no shigellosis or campylobacter indication - the dose shown is the formulary's general azithromycin course, not an indication-matched regimen.", "rationale": "A 3-day course of azithromycin is the standard first-line antibiotic for severe or prolonged Campylobacter enteritis; the source dose (500 mg once daily) matches this regimen even though the library files the row under otitis media.", "cautions": [ "Paediatric regimen is a day-1 loading dose then a halved daily dose - it cannot be calculated from a single mg/kg figure.", "The Egyptian formulary lists no shigellosis or campylobacter indication for azithromycin; the dose shown is its general susceptible-infection dosing.", "Preferred over ciprofloxacin for Campylobacter given rising fluoroquinolone resistance.", "Reserve for severe, bloody, or prolonged (over 1 week) illness, or in the immunocompromised - most cases are self-limiting and need only rehydration.", "QT prolongation risk with other QT-prolonging drugs." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Formulary general dosing for susceptible infection, oral: 10 to 12 mg/kg as a single dose on day 1 (maximum 500 mg), then 5 to 6 mg/kg once daily (maximum 250 mg) for the rest of the course. The day-1 dose and the maintenance dose are different - do not give 10 mg/kg every day. (The flat 10 mg/kg once daily, max 500 mg, is the formulary's intravenous figure.)", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "AZATRIBACT 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RIVA PHARMA S.A.E.", "price_egp": 13.5, "pack_count": 3, "unit_price": 4.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GIGAZOCIN 500MG 5 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > PIONEER", "price_egp": 27.5, "pack_count": 5, "unit_price": 5.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SYSTYMYCIN 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > NOVELL PHARMA", "price_egp": 21.5, "pack_count": 3, "unit_price": 7.17, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZITHROMASH 500 MG 3 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 48.0, "pack_count": 3, "unit_price": 16.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZALIDE 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UP PHARMA", "price_egp": 52.0, "pack_count": 3, "unit_price": 17.33, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZROLID 500 MG 6 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 126.0, "pack_count": 6, "unit_price": 21.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZERAMERATE 500 MG", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > GAMMA PHARMA", "price_egp": 28.5, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DISTABCIN 500 MG 3 DISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI", "price_egp": 43.5, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHRODOSE 100MG/5ML SUSP. 15ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL-OBOUR > AVERROES PHARMA-EGYPT", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHROPHATE 200MG/5ML SUSP. 15ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANO PHARMA > NOVELL PHARMA", "price_egp": 12.75, "pack_count": null, "unit_price": null, "strength_mg": 200.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "campylobacter-infection" }, { "id": 343, "generic": "Ciprofloxacin", "line": 3, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500 mg by mouth every 12 hours.", "adult_duration": "3 to 14 days - the formulary's range for nontyphoidal Salmonella GI infection. It gives no duration for shigellosis, campylobacter or yersiniosis.", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023, Ciprofloxacin monograph, PDF page index 373-374 (printed p364-365). The formulary lists \"infectious diarrhea\" as an adult indication but attaches no dose to it; the 500 mg every 12 hours figure is taken from its nontyphoidal Salmonella GI regimen. There is no shigellosis, campylobacter or Yersinia enterocolitica regimen in this monograph.", "rationale": "Alternative antibiotic for bloody or severe Campylobacter enteritis when azithromycin cannot be used, though resistance now makes it second choice.", "cautions": [ "Not routinely first-line in children (formulary note).", "The only Yersinia entry in this monograph is plague (Yersinia pestis), a different organism from the yersiniosis on this row - that condition has no formulary support here.", "The formulary reserves this enteric regimen for severe illness or patients at high risk of invasive disease.", "Second-line only - Campylobacter fluoroquinolone resistance is rising; use azithromycin first when available.", "Tendinitis/tendon rupture, QT prolongation, and glycaemic swings are class risks.", "Separate from antacids, iron, calcium, or zinc by 2 hours." ], "peds_mgkg_low": 10.0, "peds_mgkg_high": 10.0, "peds_max_mg": 500.0, "peds_basis": "dose", "peds_unit": "mg", "peds_note": "Formulary general paediatric dosing for mild to moderate infection: 10 mg/kg per dose twice daily by mouth (immediate release), maximum 500 mg per dose. The formulary's 15 to 20 mg/kg per dose figure is for severe infection and carries a 750 mg per-dose maximum - do not pair 15 mg/kg with a 500 mg cap. Ciprofloxacin is not first-line in children and the formulary gives no paediatric enteric-infection regimen.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 100, "high_mg": 100, "capped": false }, { "weight_kg": 20, "low_mg": 200, "high_mg": 200, "capped": false }, { "weight_kg": 30, "low_mg": 300, "high_mg": 300, "capped": false }, { "weight_kg": 40, "low_mg": 400, "high_mg": 400, "capped": false } ], "brands": [ { "trade_name": "QUINOLOROX 500MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EPCI > ROXXEN", "price_egp": 10.0, "pack_count": 10, "unit_price": 1.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ECACIPROFLOX 500 MG 20 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "FUTURE PHARMACEUTICAL INDUSTRIES (FPI) > EGYPTIAN CANADIAN PHARMACEUTICAL", "price_egp": 27.0, "pack_count": 20, "unit_price": 1.35, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ELMODOXACIN 500MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > SEA PHARM", "price_egp": 20.0, "pack_count": 10, "unit_price": 2.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROQUIN 500MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA", "price_egp": 50.0, "pack_count": 10, "unit_price": 5.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROFLOXACIN-ORGANO 500 MG 10 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANOPHARMA > ORGANO", "price_egp": 63.0, "pack_count": 10, "unit_price": 6.3, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROFAR 500MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 69.0, "pack_count": 10, "unit_price": 6.9, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROMEGA XL 500MG 10 EXT. REL. F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 48.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HEROXACIN 500MG 10 SCORED F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > HERO PHARM", "price_egp": 69.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "campylobacter-infection" } ] }