{ "schema_version": 1, "kind": "condition", "id": "chalazion", "name": "Chalazion (meibomian cyst)", "category": "chronic", "sources": "AAO Chalazion Preferred Practice Pattern · DailyMed Tobramycin Ophthalmic Solution 0.3% Package Insert (or UK eMC Tobrex 0.3% Drops SmPC)", "review_status": "reviewed", "verified_against": "DailyMed Tobramycin Ophthalmic Solution 0.3% Package Insert (or UK eMC Tobrex 0.3% Drops SmPC) · Chalazion - disease-level clinical article (chalazion-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 389, "generic": "Tobramycin", "line": 1, "is_adjunct": false, "form": "eye", "strength_mg": null, "adult_dose": "In mild to moderate disease, instill one or two drops into the affected eye(s) every four hours.", "adult_duration": null, "dose_source": "Tobramycin Ophthalmic Solution USP 0.3%, DOSAGE AND ADMINISTRATION (DailyMed SetID 3c23234a-452b-40d0-922f-37e49147d537, Alembic Pharmaceuticals): \"In mild to moderate disease, instill 1 or 2 drops into the affected eye(s) every 4 hours. In severe infections, instill 2 drops into the eye(s) hourly until improvement, following which treatment should be reduced prior to discontinuation.\" The same label sets no separate paediatric dose - see peds_note.", "rationale": "Indicated only if secondary bacterial infection is present; primary chalazion is a sterile granuloma managed with warm compresses.", "cautions": [ "Mainstay of therapy is daily warm compresses and massage towards lid margin; topical antibiotics do not penetrate non-infected granulomas.", "Refer to ophthalmologist for incision and curettage if persistent >6-8 weeks or causing astigmatism." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Children aged 2 months and over: the same regimen as adults - one or two drops into the affected eye(s) every four hours in mild to moderate disease. The label gives a single dosing regimen and does not separate adults from children, and states: \"Clinical studies have shown tobramycin to be safe and effective for use in children.\" Below 2 months it states: \"Safety and effectiveness in pediatric patients below the age of 2 months has not been established.\"", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "SWIXTOBRAM 0.3% EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CHEMIPHARM", "price_egp": 6.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "T GRAND 0.3% EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DELTA GRAND PHARMA", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TOBRAL 0.3% EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TOBRACTIVA 0.3% EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EPCI", "price_egp": 18.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AVAZIR 0.3% EYE DROPS 10 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORCHIDIA PHARMACEUTICAL INDUSTRIES > ORCHIDIA", "price_egp": 28.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TOBREX 0.3% EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "NOVARTIS > NOVARTIS SCIENTIFIC OFFICE", "price_egp": 32.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TOBRIN 0.3% EYE.OINT. 5 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 23.0, "pack_count": null, "unit_price": null, "strength_mg": 5000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AVAZIR 0.3% EYE OINT. 5 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORCHIDIA PHARMACEUTICAL INDUSTRIES > ORCHIDIA", "price_egp": 26.0, "pack_count": null, "unit_price": null, "strength_mg": 5000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "chalazion" }, { "id": 390, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Chalazion - disease-level clinical article (chalazion-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Biopsy is required for recurrent chalazia to rule out sebaceous cell carcinoma." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "chalazion" }, { "id": 391, "generic": "Doxycycline", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": null, "adult_dose": "100 mg by mouth twice daily", "adult_duration": "10 days", "dose_source": "Chalazion (meibomian cyst) - disease-level clinical article (chalazion-clinical.txt)", "rationale": "Oral tetracycline antibiotic when secondary infection or blepharitis is associated with a chalazion.", "cautions": [ "Contraindicated in pregnancy and children <8 years (permanent dental staining and bone growth inhibition). Doxycycline 100 mg Capsules SmPC says, in section 4.2, \"Doxycycline should not be used in children aged younger than 8 years due to the risk of teeth discolouration\", in section 4.3, \"Doxycycline is contraindicated in pregnancy\", and in section 4.4 that tetracyclines used during tooth development \"may cause permanent discolouration of the teeth (yellow-grey-brown)\" and that \"Enamel hypoplasia has also been reported\".", "Photosensitivity reaction; instruct patient to use broad-spectrum sun protection.", "Take with full glass of water while standing to avoid esophageal ulceration." ], "peds_mgkg_low": 2.2, "peds_mgkg_high": 2.2, "peds_max_mg": 100.0, "peds_basis": "dose", "peds_unit": "mg", "peds_note": "Children and Adolescents: Oral, IV: 2.2 mg/kg/dose every 12 hours, maximum dose: 100 mg/dose.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 22, "high_mg": 22, "capped": false }, { "weight_kg": 20, "low_mg": 44, "high_mg": 44, "capped": false }, { "weight_kg": 30, "low_mg": 66, "high_mg": 66, "capped": false }, { "weight_kg": 40, "low_mg": 88, "high_mg": 88, "capped": false } ], "brands": [ { "trade_name": "FARCODOXIN 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 11.0, "pack_count": 10, "unit_price": 1.1, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXY M.R.100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ADWIA", "price_egp": 12.0, "pack_count": 10, "unit_price": 1.2, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GRANUDOXY 100MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS > PIERRE FRANCE", "price_egp": 12.0, "pack_count": 10, "unit_price": 1.2, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXYDOX 100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 23.0, "pack_count": 10, "unit_price": 2.3, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXYMYCIN 100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 30.0, "pack_count": 10, "unit_price": 3.0, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXYCOST 200MG 10 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PENTA PHARMA", "price_egp": 43.0, "pack_count": 10, "unit_price": 4.3, "strength_mg": 200.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TABOCINE 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "TABUK PHARMACEUTICAL MANUFACTURING COMPANY > TABUK PHARMA", "price_egp": 46.0, "pack_count": 10, "unit_price": 4.6, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VIBRAMYCIN 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER", "price_egp": 65.0, "pack_count": 10, "unit_price": 6.5, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "chalazion" } ] }