{ "schema_version": 1, "kind": "condition", "id": "chronic-ischaemic-heart-disease", "name": "Chronic ischaemic heart disease", "category": "acute", "sources": "Egyptian National Drug Formulary - cardiovascular.pdf, Atorvastatin monograph (chapter PDF p207) · Egyptian National Drug Formulary - cardiovascular.pdf, Clopidogrel monograph (chapter PDF p119) · Egyptian National Drug Formulary - cardiovascular.pdf, Isosorbide mononitrate monograph (chapter PDF p71) · Gillen C, Shams P, Goyal A. Stable Angina. [Updated 2026 Jun 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Bookshelf ID NBK559016.", "review_status": "reviewed", "verified_against": "Egyptian National Drug Formulary - cardiovascular.pdf, Atorvastatin monograph (chapter PDF p207) · Egyptian National Drug Formulary - cardiovascular.pdf, Clopidogrel monograph (chapter PDF p119) · Egyptian National Drug Formulary - cardiovascular.pdf, Isosorbide mononitrate monograph (chapter PDF p71) · Gillen C, Shams P, Goyal A. Stable Angina. [Updated 2026 Jun 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Bookshelf ID NBK559016.", "verified_date": "2026-08", "treatments": [ { "id": 430, "generic": "Atorvastatin", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": null, "adult_dose": "80 mg once daily (secondary-prevention statin dose for established atherosclerotic/ischaemic heart disease).", "adult_duration": "Long-term / indefinite.", "dose_source": "Egyptian National Drug Formulary - cardiovascular.pdf, Atorvastatin monograph (chapter PDF p207)", "rationale": "High-intensity statin therapy is a core secondary-prevention drug for anyone with established coronary artery disease, reducing future cardiovascular events regardless of baseline cholesterol.", "cautions": [ "New or worsening chest pain, breathlessness at rest, syncope, symptoms suggesting unstable angina or heart failure.", "Check liver function and creatine kinase before starting and if muscle symptoms develop.", "Avoid in active liver disease and in pregnancy/breastfeeding.", "Watch for myopathy, especially with interacting drugs (e.g. clarithromycin, fibrates).", "Counsel on the need for long-term adherence even though the patient is asymptomatic." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not applicable - chronic ischaemic heart disease is an adult condition; paediatric statin dosing (from age 10, for familial hypercholesterolaemia only) is specialist-set and is not reproduced here.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "PREVENVAST 10 MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 6.5, "pack_count": 10, "unit_price": 0.65, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANTICHOL 10 MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JEDCO INT. CO. FOR PHARMACEUTICALS", "price_egp": 8.5, "pack_count": 10, "unit_price": 0.85, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LIPOVAST 10MG 7 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR", "price_egp": 9.25, "pack_count": 7, "unit_price": 1.32, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LIRIMAR 80 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RIVA PHARMA S.A.E.", "price_egp": 29.0, "pack_count": 10, "unit_price": 2.9, "strength_mg": 80.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LIPINORM 10 MG 7 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 28.0, "pack_count": 7, "unit_price": 4.0, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ATOR 40 MG 10 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 106.0, "pack_count": 10, "unit_price": 10.6, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HIPOLIXAVAST 10 MG 30 CHEW. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI", "price_egp": 114.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HIPOLIXAVAST 20 MG 30 CHEW. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI", "price_egp": 127.5, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "chronic-ischaemic-heart-disease" }, { "id": 431, "generic": "Isosorbide-5-mononitrate", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": null, "adult_dose": "Immediate-release 20 mg twice daily, the two doses given about 7 hours apart (e.g. 8 AM and 3 PM) to reduce nitrate-tolerance development.", "adult_duration": "Ongoing, as directed (chronic anti-anginal prophylaxis).", "dose_source": "Egyptian National Drug Formulary - cardiovascular.pdf, Isosorbide mononitrate monograph (chapter PDF p71)", "rationale": "Isosorbide mononitrate is a standard oral anti-anginal used to prevent angina symptoms in chronic ischaemic heart disease.", "cautions": [ "Contraindicated with PDE5 inhibitors (sildenafil, tadalafil) - risk of severe hypotension.", "Causes headache and postural hypotension, especially at initiation.", "Give the two daily doses asymmetrically (not evenly 12 hours apart) to preserve a nitrate-free interval and avoid tolerance.", "Does not have a fast enough onset to abort an acute anginal attack - use sublingual GTN for acute episodes." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not used in children; angina from coronary artery disease is an adult condition and paediatric dosing is not established.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "ISOSORBIDE 20MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 3.0, "pack_count": 10, "unit_price": 0.3, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ISOSORBIDE 40MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 4.5, "pack_count": 10, "unit_price": 0.45, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CARDIOGUARD M 20MG SR 10CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMOUN", "price_egp": 6.0, "pack_count": 10, "unit_price": 0.6, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CARDIOGUARD M 40 MG SR 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMOUN", "price_egp": 10.0, "pack_count": 10, "unit_price": 1.0, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANGIOFOX (EFFOX) 40 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM", "price_egp": 28.0, "pack_count": 20, "unit_price": 1.4, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MONOMAK 40MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "OCTOBER PHARMA", "price_egp": 43.0, "pack_count": 20, "unit_price": 2.15, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MONOMAK DEPOT 100MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "OCTOBER PHARMA", "price_egp": 48.0, "pack_count": 10, "unit_price": 4.8, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANGIOFOX (EFFOX) 50MG LONG 20 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM", "price_egp": 132.0, "pack_count": 20, "unit_price": 6.6, "strength_mg": 50.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "chronic-ischaemic-heart-disease" }, { "id": 432, "generic": "Clopidogrel", "line": 3, "is_adjunct": false, "form": "oral.solid", "strength_mg": null, "adult_dose": "75 mg once daily (maintenance antiplatelet dose for secondary prevention after myocardial infarction, ischaemic stroke, or atherosclerotic disease).", "adult_duration": "Long-term / indefinite, as directed.", "dose_source": "Egyptian National Drug Formulary - cardiovascular.pdf, Clopidogrel monograph (chapter PDF p119)", "rationale": "Clopidogrel provides ongoing antiplatelet secondary prevention in confirmed atherosclerotic coronary disease.", "cautions": [ "Increases bleeding risk - caution with other antiplatelets/anticoagulants and before surgery.", "Avoid in active pathological bleeding (e.g. peptic ulcer, intracranial haemorrhage).", "Effectiveness is reduced by strong CYP2C19 inhibitors such as omeprazole - use pantoprazole instead if a PPI is needed.", "If combined with aspirin, bleeding risk is higher - confirm indication and planned duration of dual therapy." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not used in children; ischaemic heart disease is an adult condition.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "BLOTAGRIL 75MG 30 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEDIZEN PHARMACEUTICAL INDUSTRIES", "price_egp": 33.0, "pack_count": 30, "unit_price": 1.1, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ITOLAVIX 75 MG 30 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA > INTERNATIONAL TRADING OFFICE", "price_egp": 54.0, "pack_count": 30, "unit_price": 1.8, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BORGAVIX 75MG 30 F.C. TABLETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "BORG", "price_egp": 66.0, "pack_count": 30, "unit_price": 2.2, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SIGAGREL 75MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 30.0, "pack_count": 10, "unit_price": 3.0, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLOPACIRC 75 MG 30 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "COPAD PHARMA", "price_egp": 117.0, "pack_count": 30, "unit_price": 3.9, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "IDIAVIX 75MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "INTERNATIONAL DRUG AGENCY (IDI)", "price_egp": 48.0, "pack_count": 10, "unit_price": 4.8, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PLAVIX 75 MG 28 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI WINTHROP > SANOFI", "price_egp": 311.0, "pack_count": 28, "unit_price": 11.11, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PLAVIX 300 MG 30 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI WINTHROP > SANOFI", "price_egp": 704.0, "pack_count": 30, "unit_price": 23.47, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "chronic-ischaemic-heart-disease" } ] }