{ "schema_version": 1, "kind": "condition", "id": "cystic-fibrosis", "name": "Cystic Fibrosis", "category": "chronic", "sources": "Cystic Fibrosis - StatPearls (NCBI Bookshelf NBK493206) - https://www.ncbi.nlm.nih.gov/books/NBK493206/ · ICPC-3 (WONCA International Classification of Primary Care, 3rd edition) class RD99.02 - condition scope only, no dose · No dose - referral pathway, no medicine given in primary care · Egyptian National Drug Formulary - Respiratory Medicines 2026 (Ipratropium Bromide monograph) · Egyptian National Drug Formulary - Respiratory Medicines 2026 (Salbutamol monograph)", "review_status": "reviewed", "verified_against": "No dose - referral pathway, no medicine given in primary care", "verified_date": "2026-08", "treatments": [ { "id": 541, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": "A genetic disorder causing thick mucus secretions that lead to recurrent lung infections and pancreatic insufficiency; rare but not absent in Egypt given the effect of consanguinity on recessive-disease risk. Management is specialist, at a paediatric respiratory or CF centre, with enzyme replacement and airway clearance, so the GP's role is recognition and referral.", "adult_duration": "Refer, with advice", "dose_source": "No dose - referral pathway, no medicine given in primary care", "rationale": "A genetic disorder causing thick mucus secretions that lead to recurrent lung infections and pancreatic insufficiency; rare but not absent in Egypt given the effect of consanguinity on recessive-disease risk. Management is specialist, at a paediatric respiratory or CF centre, with enzyme replacement and airway clearance, so the GP's role is recognition and referral.", "cautions": [ "Rare in Egyptian primary care.", "Referral is the pathway; the medicines listed alongside are what primary care can give before or while it happens.", "RED FLAG - Recurrent chest infections with failure to thrive in an infant, meconium ileus in a newborn, or salty-tasting skin reported by parents: refer for specialist assessment." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Children follow the same pathway: recognise and refer. No primary-care medicine is implied.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "cystic-fibrosis" }, { "id": 543, "generic": "Salbutamol", "line": 1, "is_adjunct": false, "form": "oral.inhalation", "strength_mg": null, "adult_dose": "One or two inhalations of 100 micrograms up to 4 times a day; no more than 8 inhalations in 24 hours and usually not repeated inside 4 hours", "adult_duration": null, "dose_source": "Egyptian National Drug Formulary - Respiratory Medicines 2026 (Salbutamol monograph) - verbatim: \"Oral inhalation, one inhalation (100 mcg) or two inhalations up to 4 times a day for persistent symptoms.\"", "rationale": "Cystic-fibrosis airways obstruct and wheeze like asthma, and an inhaler is the one thing a primary-care doctor can hand the patient the same day while specialist care is arranged.", "cautions": [ "Tremor and jitteriness are common and dose-related, and children may become noticeably excitable.", "Palpitations and a fast pulse can occur; check the pulse if the patient is using it often.", "Needing it more and more often means the disease is worsening - that is a reason to escalate care, not to increase the inhaler.", "Do not use it in anyone hypersensitive to salbutamol or to any part of the formulation." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Under 12 years: one or two inhalations of 100 micrograms up to 4 times a day, not exceeding 800 micrograms daily and not more than 6 times in 24 hours.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "AEROLIN 100MCG/DOSE INHALER", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO > 3M HEALTH CARE-U.K.", "price_egp": 7.3, "pack_count": null, "unit_price": null, "strength_mg": 0.1, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BUTALIN 100MCG/ACTUATION 200 DOSES", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JULPHAR", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 0.1, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SALBOVENT RESPIRATOR 5MG/ML SOLN. 20 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 17.5, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BRONCHOLIN S 0.5% RESPIRATOR SOLN. 30 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 37.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ALVEOTRACK 5 MG/ML INH. SOLN. 30 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MDI PHARMA", "price_egp": 49.0, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VENTAL INHALER 100 MCG/DOSE 200 DOSES", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 72.0, "pack_count": null, "unit_price": null, "strength_mg": 0.1, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VENTOLIN DISKUS 200MCG/DOSE ACCUHALER", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE", "price_egp": 86.0, "pack_count": null, "unit_price": null, "strength_mg": 0.2, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VENTOLIN EVOHALER 100MCG/ACTUATION INHALER", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE", "price_egp": 86.0, "pack_count": null, "unit_price": null, "strength_mg": 0.1, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "OPICHESTAL SYRUP 120ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL-OBOUR", "price_egp": 2.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "SALBUTAMOL 2MG/5ML SYRUP 120ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 3.5, "pack_count": null, "unit_price": null, "strength_mg": 2.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "cystic-fibrosis" }, { "id": 542, "generic": "Ipratropium bromide", "line": 1, "is_adjunct": true, "form": "oral.inhalation", "strength_mg": null, "adult_dose": "Nebulised 250 to 500 micrograms 3 to 4 times a day; 500 micrograms for an acute episode", "adult_duration": null, "dose_source": "Egyptian National Drug Formulary - Respiratory Medicines 2026 (Ipratropium Bromide monograph) - verbatim: \"Maintenance therapy: 250 - 500 micrograms 3 to 4 times daily.\"", "rationale": "Adding an anticholinergic to the beta-2 agonist widens the airway a little further in cystic-fibrosis airway obstruction; it is a supportive measure, not a substitute for specialist care.", "cautions": [ "Do not use it in anyone allergic to ipratropium or to atropine.", "Keep the nebuliser mist out of the eyes - it can blur vision and raise eye pressure in glaucoma.", "This is symptom relief only. Cystic fibrosis is managed by a specialist centre and the referral still stands." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "6 to 12 years: 250 micrograms a dose, up to 1 mg in total each day. No dose under 6 years in the sources opened.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "ASMATROPIM 250MCG/ML 20 NEBULIZER VIAL SOLN.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL ADVANCED PHARMACEUTICALS (GAP) > GLOBAL PHARMACEUTICAL INDUSTRIES", "price_egp": 70.0, "pack_count": null, "unit_price": null, "strength_mg": 0.25, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "IPRATROPIUM VIATRIS 0.25MG/ML (CHILDREN) 10 UNIT DOSE VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "LABORATOIRE UNITHER > ONE PHARMA MEDICS", "price_egp": 74.0, "pack_count": null, "unit_price": null, "strength_mg": 0.25, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "IPRATROPIUM VIATRIS 0.5MG/2ML (ADULTS) 10 UNIT DOSE VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "LABORATOIRE UNITHER > ONE PHARMA MEDICS", "price_egp": 80.0, "pack_count": null, "unit_price": null, "strength_mg": 0.5, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LUNGOTROPIUM 250MCG/1ML 20 UNIT DOSE VIAL NEBULIZER SOLN", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EVA PHARMA", "price_egp": 152.0, "pack_count": null, "unit_price": null, "strength_mg": 0.25, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ASMATROPIM 500MCG/2ML 20 NEBULIZER VIAL SOLN.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL ADVANCED PHARMACEUTICALS (GAP) > GLOBAL PHARMACEUTICAL INDUSTRIES", "price_egp": 164.0, "pack_count": null, "unit_price": null, "strength_mg": 0.5, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LUNGOTROPIUM 500MCG/2ML 20 UNIT DOSE VIAL NEBULIZER SOLN", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EVA PHARMA", "price_egp": 164.0, "pack_count": null, "unit_price": null, "strength_mg": 0.5, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ATROVENT 250MCG/2ML 20 UNIT DOSE INH. VIAL.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "BOEHRINGER INGELHEIM", "price_egp": 286.0, "pack_count": null, "unit_price": null, "strength_mg": 0.25, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ATROVENT 500 MCG/2ML 20 UNIT DOSE INH. VIAL.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "BOEHRINGER INGELHEIM", "price_egp": 286.0, "pack_count": null, "unit_price": null, "strength_mg": 0.5, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "cystic-fibrosis" } ] }