{ "schema_version": 1, "kind": "condition", "id": "dental-abscess", "name": "Acute dental abscess (odontogenic infection)", "category": "infectious", "sources": "Egyptian National Drug Formulary - Antimicrobial 2023 · SDCEP Dental Prescribing 2020", "review_status": "reviewed", "verified_against": "Egyptian National Drug Formulary - Antimicrobial 2023 · SDCEP Dental Prescribing 2020 · Acute dental abscess (odontogenic infection) - disease-level clinical article (dental-abscess-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 559, "generic": "Amoxicillin + Clavulanic acid", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 1000.0, "adult_dose": "1 g (875/125 mg) orally twice daily", "adult_duration": "5 days", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023", "rationale": "Beta-lactam combined with a beta-lactamase inhibitor for odontogenic infection, covering the mixed oral aerobic and anaerobic flora typically responsible; used alongside urgent dental drainage or extraction, since antibiotics alone do not resolve a dental abscess and are not a substitute for source control.", "cautions": [ "Antibiotics are adjuncts to dental intervention (drainage/extraction); refer urgently to dentist.", "Contraindicated in penicillin hypersensitivity.", "Take with meals to reduce GI adverse effects." ], "peds_mgkg_low": 25.0, "peds_mgkg_high": 45.0, "peds_max_mg": 1750.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "Dosed as amoxicillin component in 2 divided doses daily", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 250, "high_mg": 450, "capped": false }, { "weight_kg": 20, "low_mg": 500, "high_mg": 900, "capped": false }, { "weight_kg": 30, "low_mg": 750, "high_mg": 1350, "capped": false }, { "weight_kg": 40, "low_mg": 1000, "high_mg": 1750, "capped": true } ], "brands": [ { "trade_name": "E-MOXCLAV 1G 10 F.C. 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TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > NOVELL PHARMA", "price_egp": 38.5, "pack_count": 10, "unit_price": 3.85, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MACLAVEX 1 GM 14 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 105.0, "pack_count": 14, "unit_price": 7.5, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLAVIMOX 1 GM 12 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 130.0, "pack_count": 12, "unit_price": 10.83, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MEGAMOX 1 GM 14 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AL JAZEERA PHARMACEUTICAL > HIKMA PHARMA", "price_egp": 178.0, "pack_count": 14, "unit_price": 12.71, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLAVOCILLIN 1 GM 10 DISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > ORGANOPHARMA", "price_egp": 106.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AUGMENTIN ADULTS 1GM/125MG 12 PWD. ORAL SUSP. SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE", "price_egp": 169.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LARYNCLAVE 125/31 PD. FOR ORAL SUSP. 70ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR > AL ROWAD PHARMACEUTICAL INDUSTRIAL CO.", "price_egp": 8.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "MEGACLAVOX 156MG/5ML PD. FOR SUSP. 60 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 8.0, "pack_count": null, "unit_price": null, "strength_mg": 156.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "dental-abscess" }, { "id": 561, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Acute dental abscess (odontogenic infection) - disease-level clinical article (dental-abscess-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Systemic spread of infection can progress to extra-oral head/neck swellings, lymphadenopathy, or sepsis." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "dental-abscess" }, { "id": 560, "generic": "Metronidazole", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500 mg orally three times daily", "adult_duration": "5 days", "dose_source": "SDCEP Dental Prescribing 2020", "rationale": "Antibiotic targeting the anaerobic bacteria implicated in odontogenic infection; used first-line for patients with penicillin allergy in acute dental abscess.", "cautions": [ "May cause metallic taste and nausea.", "Strictly avoid alcohol and propylene glycol-containing products during treatment and for 3 days (72 hours) after the last dose - Egyptian National Drug Formulary, Antimicrobial 2023.", "Metronidazole is a first-line option for patients with penicillin allergy." ], "peds_mgkg_low": 22.5, "peds_mgkg_high": 22.5, "peds_max_mg": 1500.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "7.5 mg/kg per dose 3 times daily (22.5 mg/kg/day)", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 225, "high_mg": 225, "capped": false }, { "weight_kg": 20, "low_mg": 450, "high_mg": 450, "capped": false }, { "weight_kg": 30, "low_mg": 675, "high_mg": 675, "capped": false }, { "weight_kg": 40, "low_mg": 900, "high_mg": 900, "capped": false } ], "brands": [ { "trade_name": "DUMOZOL 500MG 20 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM > ALPHARMA-DENMARK", "price_egp": 7.0, "pack_count": 20, "unit_price": 0.35, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZOLGUARD 500MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA CO. > UNIPHARMA", "price_egp": 9.0, "pack_count": 20, "unit_price": 0.45, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NITROFECTAZOLE 500 MG 20 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GYPTO PHARMA", "price_egp": 10.5, "pack_count": 20, "unit_price": 0.53, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLAGICURE FORTE 500 MG 20 F.C. TAB", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 23.0, "pack_count": 20, "unit_price": 1.15, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TRICHOGYL 500MG 12 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NASR", "price_egp": 15.0, "pack_count": 12, "unit_price": 1.25, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLAGELLAT FORTE 500MG 20 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 30.0, "pack_count": 20, "unit_price": 1.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GEDAZOLE 500MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JEDCO INT. CO. FOR PHARMACEUTICALS", "price_egp": 34.0, "pack_count": 20, "unit_price": 1.7, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "METROGYPTON 500 MG 20 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GYPTO PHARMA", "price_egp": 34.0, "pack_count": 20, "unit_price": 1.7, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DUMOZOL 125MG/5ML SUSP. 125ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM > ALPHARMA-DENMARK", "price_egp": 5.75, "pack_count": null, "unit_price": null, "strength_mg": 125.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "METROZOLE 125MG/5ML SUSP. 120 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 19.5, "pack_count": null, "unit_price": null, "strength_mg": 125.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "dental-abscess" }, { "id": 562, "generic": "Clindamycin", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 300.0, "adult_dose": "300 mg orally every 6 hours", "adult_duration": "5 days", "dose_source": "Periodontal Abscess - StatPearls - NCBI Bookshelf (NBK560625) for the indication - verbatim: \"Clindamycin is recommended as an alternative for patients with penicillin allergies.\" Dose from Egyptian National Drug Formulary - antimicrobial-2023.pdf, Clindamycin monograph (chapter PDF p287) - verbatim: \"Oral: 150–300 mg every 6 hours.\" Paediatric dose from the same monograph, the oral capsule line - verbatim: \"Oral: Infants, Children, and Adolescents: Hydrochloride salt (capsule): 8 to 20 mg/kg/day divided every 6 to 8 hours.\" Neither source states a course length for odontogenic infection; 5 days matches the co-amoxiclav and metronidazole courses already sourced for acute dental abscess.", "rationale": "The alternative when penicillin is not an option. It penetrates bone and covers the oral anaerobes that drive odontogenic infection.", "cautions": [ "Antibiotics are an adjunct, not the treatment. The abscess still needs drainage or dental treatment; a course of clindamycin alone will not resolve it.", "Warn about diarrhoea. Clindamycin carries the highest Clostridioides difficile risk of the oral antibiotics here - stop it and reassess if diarrhoea develops during or after the course.", "Take with a full glass of water to avoid oesophageal irritation." ], "peds_mgkg_low": 8.0, "peds_mgkg_high": 20.0, "peds_max_mg": null, "peds_basis": "day", "peds_unit": "mg", "peds_note": "8 to 20 mg/kg/day divided every 6 to 8 hours.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 80, "high_mg": 200, "capped": false }, { "weight_kg": 20, "low_mg": 160, "high_mg": 400, "capped": false }, { "weight_kg": 30, "low_mg": 240, "high_mg": 600, "capped": false }, { "weight_kg": 40, "low_mg": 320, "high_mg": 800, "capped": false } ], "brands": [ { "trade_name": "ADCOCLINDACE 300 MG 16 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 24.0, "pack_count": 16, "unit_price": 1.5, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLINACYN 300MG 16 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA > EGYPTIAN PHARMACISTS COMPANY", "price_egp": 31.5, "pack_count": 16, "unit_price": 1.97, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLINDAM 300 MG 16 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA > OCTOBER PHARMA", "price_egp": 75.0, "pack_count": 16, "unit_price": 4.69, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MEPACLIND 300MG 8 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEPACO", "price_egp": 38.0, "pack_count": 8, "unit_price": 4.75, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLINDACINE ART 300 MG 12 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > ART PHARMA", "price_egp": 76.0, "pack_count": 12, "unit_price": 6.33, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ALFACLINDAMYCIN 300 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ATCO PHARMA > ROTABIOGEN", "price_egp": 69.0, "pack_count": 10, "unit_price": 6.9, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DALACIN C 300MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER", "price_egp": 114.0, "pack_count": 10, "unit_price": 11.4, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "KLENDABIOTICAM 1 % TOP. SOLUTION", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PANAX PHARMA", "price_egp": 8.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ADCOCLINDACE 10MG/ML TOP. SOL.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "dental-abscess" } ] }