{ "schema_version": 1, "kind": "condition", "id": "drug-induced-dermatitis", "name": "Drug-induced dermatitis", "category": "acute", "sources": "Egyptian National Drug Formulary - Respiratory Medicines 2026, loratadine monograph (respiratory-2026.pdf page index 25, printed p14) · Egyptian National Drug Formulary - Respiratory System 2026 (loratadine monograph) · Al Aboud DM, Nessel TA, Hafsi W. Cutaneous Adverse Drug Reaction. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Bookshelf ID: NBK533000.", "review_status": "reviewed", "verified_against": "Egyptian National Drug Formulary - Respiratory Medicines 2026, loratadine monograph (respiratory-2026.pdf page index 25, printed p14)", "verified_date": "2026-08", "treatments": [ { "id": 613, "generic": "Loratadine", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 10.0, "adult_dose": "10 mg once daily", "adult_duration": "Not specified in the formulary", "dose_source": "Egyptian National Drug Formulary - Respiratory Medicines 2026, loratadine monograph (respiratory-2026.pdf page index 25, printed p14)", "rationale": "A drug eruption is an itchy, often urticarial or morbilliform rash; a standard non-sedating oral antihistamine controls the itch while the causative drug is withdrawn, the same symptomatic role it plays in urticaria.", "cautions": [ "Excreted in breast milk; the formulary does not recommend use in breastfeeding women.", "Renal impairment with creatinine clearance under 30 mL/min: 10 mg every 48 hours", "Signs of a severe cutaneous adverse reaction - mucosal involvement, blistering, skin sloughing, or systemic symptoms - need emergency referral for possible Stevens-Johnson syndrome or DRESS.", "Identify and stop the suspected causative drug - this is the definitive treatment; the antihistamine only controls itch while the eruption resolves.", "Urgent same-day referral if there is mucosal (mouth, eye, genital) involvement, blistering, skin sloughing, or systemic symptoms - these suggest Stevens-Johnson syndrome or DRESS, not a simple exanthematous drug eruption.", "Document the reaction and the culprit drug clearly in the patient's record/allergy list to prevent re-exposure.", "Loratadine is non-sedating; use caution in severe hepatic impairment." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Children over 6 years: 10 mg once daily. Children 2 to 6 years: 5 mg once daily. Alternative weight-based dosing for children under 12 years: 30 kg or less, 5 mg once daily; over 30 kg, 10 mg once daily. Under 2 years: safety and efficacy not established.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "2 to under 6 years", "age_min_months": 24, "age_max_months": 71, "dose_text": "5 mg once daily" }, { "label": "6 years and over", "age_min_months": 72, "age_max_months": 216, "dose_text": "10 mg once daily" } ], "peds_doses": null, "brands": [ { "trade_name": "HISTALONG 10 MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JEDCO INT. CO. FOR PHARMACEUTICALS", "price_egp": 17.0, "pack_count": 20, "unit_price": 0.85, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "UNILORATADINE 10 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA CO. > UNIPHARMA", "price_egp": 17.0, "pack_count": 20, "unit_price": 0.85, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SEDCLARIT 10MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 19.5, "pack_count": 20, "unit_price": 0.97, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LORATADINE 10MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR", "price_egp": 25.5, "pack_count": 10, "unit_price": 2.55, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ONY 10 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA", "price_egp": 51.0, "pack_count": 20, "unit_price": 2.55, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ALLERGETONE 10 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MARCYRL PHARMACEUTICAL INDUSTRIES (MPI) > SPLENDID PHARMA", "price_egp": 66.0, "pack_count": 20, "unit_price": 3.3, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLARITINE 10MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO > BAYER HEALTHCARE", "price_egp": 110.0, "pack_count": 20, "unit_price": 5.5, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ALLERGIRAZ 10MG 30 DISINTEGRATING TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JEDCO INT. CO. FOR PHARMACEUTICALS > ELRAZY PHARMACEUTICALS-EGYPT", "price_egp": 31.5, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LORANO 5MG/5ML SYRUP 60ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM", "price_egp": 5.0, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "UNILORATADINE 5MG/5ML SYRUP 100 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA CO. > UNIPHARMA", "price_egp": 9.0, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "drug-induced-dermatitis" } ] }