{ "schema_version": 1, "kind": "condition", "id": "echinococcosis", "name": "Echinococcosis (Hydatid Disease)", "category": "chronic", "sources": "Echinococcus Granulosus - StatPearls (NCBI Bookshelf NBK539751) - https://www.ncbi.nlm.nih.gov/books/NBK539751/ · ICPC-3 (WONCA International Classification of Primary Care, 3rd edition) class DD07.10 - condition scope only, no dose · Egyptian National Drug Formulary - Antimicrobial 2023 (albendazole monograph, p26)", "review_status": "reviewed", "verified_against": "Egyptian National Drug Formulary - Antimicrobial 2023 (albendazole monograph, p26)", "verified_date": "2026-08", "treatments": [ { "id": 640, "generic": "Albendazole", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 400.0, "adult_dose": "10-15 mg/kg/day in two divided doses, each dose capped at 400 mg", "adult_duration": "1 to 6 months, decided by the cyst stage and the response", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (albendazole monograph, p26)", "rationale": "The cited article names albendazole as the drug of choice for hydatid disease at 10-15 mg/kg/day, with mebendazole 40-50 mg/kg/day as the other option. The formulary's albendazole monograph names cystic hydatid disease of the liver, lung and peritoneum caused by the larval form of the dog tapeworm as an indication and gives the weight-based rule below, so the drug, the indication and the dose all come from named documents. Drug treatment alone is for cysts the article calls CE1 and CE3a under 5 cm in liver or lung, for disease in two or more organs, and for a patient who cannot have surgery; it is also given around surgery or a percutaneous procedure to stop the cyst coming back.", "cautions": [ "DO NOT GIVE IT TO SHRINK A CYST THAT MIGHT BURST. The cited article says benzimidazole treatment is contraindicated in cysts vulnerable to rupture, and in early pregnancy.", "THIS IS NOT A DECISION TO MAKE ALONE. Which cyst is treated with a drug, which with surgery and which with the PAIR needle procedure depends on the ultrasound stage. Anaphylaxis is a real risk if a cyst is punctured or leaks, and the article says the operator must be equipped to deal with it.", "Monitor while on treatment: the cited article asks for white cell count, liver transaminases and ultrasound every 3 to 6 months at first, then yearly once stable.", "Do not give to anyone with a known allergy to albendazole or another benzimidazole.", "Mebendazole 40-50 mg/kg/day is the alternative the article gives if albendazole cannot be used." ], "peds_mgkg_low": 5.0, "peds_mgkg_high": 7.5, "peds_max_mg": 400.0, "peds_basis": "dose", "peds_unit": "mg", "peds_note": "Hydatid disease in children and adolescents: 5-7.5 mg/kg per dose twice daily for 1 to 6 months, each dose capped at 400 mg. The grid above is per dose, not per day - twice this amount is given in 24 hours.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 50, "high_mg": 75, "capped": false }, { "weight_kg": 20, "low_mg": 100, "high_mg": 150, "capped": false }, { "weight_kg": 30, "low_mg": 150, "high_mg": 225, "capped": false }, { "weight_kg": 40, "low_mg": 200, "high_mg": 300, "capped": false } ], "brands": [ { "trade_name": "ALBENDAZOLE 400 MG 6 TABS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARMA CURE PHARMACEUTICALS > PHARMA CURE", "price_egp": 46.0, "pack_count": 6, "unit_price": 7.67, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANTIZOLE 100MG/5ML SUSP. 30ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 19.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ALZENTAL 20MG/ML SUSP. 20ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 21.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "echinococcosis" }, { "id": 641, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": "Hydatid cyst disease from contact with dogs and livestock, seen in Egypt's rural farming communities. Diagnosis and treatment (surgery and/or albendazole) requires imaging and specialist care; GP recognises the possibility and refers.", "adult_duration": "Refer, with advice", "dose_source": "No dose - referral pathway, no medicine given in primary care", "rationale": "Hydatid cyst disease from contact with dogs and livestock, seen in Egypt's rural farming communities. Diagnosis and treatment (surgery and/or albendazole) requires imaging and specialist care; GP recognises the possibility and refers.", "cautions": [ "The drug rows above are what the treating service gives. They are here so that the referral is an informed one and so the GP can recognise the regimen the patient comes back on - not as permission to start it without the referral.", "RED FLAG - Sudden severe pain or an allergic reaction suggesting cyst rupture, jaundice, or coughing blood from a lung cyst: refer urgently." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Children follow the same pathway: recognise and refer. No primary-care medicine is implied.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "echinococcosis" } ] }