{ "schema_version": 1, "kind": "condition", "id": "febrile-seizure-simple", "name": "Simple Febrile Seizure", "category": "infectious", "sources": "AAP Clinical Practice Guideline: Febrile Seizures 2011 · Egyptian National Drug Formulary, nervous system 2025, diazepam monograph, febrile convulsions (printed p. 12) · Febrile Seizure - StatPearls - NCBI Bookshelf - disease-level clinical article (febrile-seizure-simple-full.txt)", "review_status": "reviewed", "verified_against": "AAP Clinical Practice Guideline: Febrile Seizures 2011 · Egyptian National Drug Formulary, nervous system 2025, diazepam monograph, febrile convulsions (printed p. 12) · No dose - referral pathway, no medicine given in primary care · Febrile Seizure - StatPearls - NCBI Bookshelf - disease-level clinical article (febrile-seizure-simple-full.txt)", "verified_date": "2026-08", "treatments": [ { "id": 716, "generic": "Paracetamol", "line": 1, "is_adjunct": false, "form": "oral.liquid", "strength_mg": 120.0, "adult_dose": "Not applicable - pediatric entry", "adult_duration": "2-3 days during febrile illness", "dose_source": "AAP Clinical Practice Guideline: Febrile Seizures 2011", "rationale": "Antipyretic and analgesic given for the child's comfort during the febrile illness; it does not prevent febrile seizure recurrence and is not given to treat the seizure itself.", "cautions": [ "CRITICAL COUNSELING: Antipyretics improve child comfort but DO NOT prevent febrile seizure recurrence per AAP 2011 guidelines.", "A simple febrile seizure is defined as generalized tonic-clonic, <15 minutes duration, non-recurrent within 24 hours in a neurologically normal child aged 6-60 months.", "Reassure parents: simple febrile seizures carry no increased risk of brain damage or mortality.", "Antipyretics relieve fever distress but do NOT reduce the risk of febrile seizure recurrence.", "500 mg is the per-dose ceiling used here for a child. 1000 mg is the adult dose and does not belong in a weight calculation - the daily 60 mg/kg limit is the one that binds first in any case." ], "peds_mgkg_low": 15.0, "peds_mgkg_high": 15.0, "peds_max_mg": 500.0, "peds_basis": "dose", "peds_unit": "mg", "peds_note": "Give 15 mg/kg every 4-6 hours as needed (or rectal suppository if vomiting); max 60 mg/kg/day", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 150, "high_mg": 150, "capped": false }, { "weight_kg": 20, "low_mg": 300, "high_mg": 300, "capped": false }, { "weight_kg": 30, "low_mg": 450, "high_mg": 450, "capped": false }, { "weight_kg": 40, "low_mg": 500, "high_mg": 500, "capped": true } ], "brands": [ { "trade_name": "CETAMOL 120MG/5ML PEDIATRIC SYRUP 120 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 8.5, "pack_count": null, "unit_price": null, "strength_mg": 120.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PARAGESIC BABY 120MG/5ML 120ML SUSP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 36.0, "pack_count": null, "unit_price": null, "strength_mg": 120.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PARAMOL 120MG/5ML SYRUP 125ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR", "price_egp": 36.0, "pack_count": null, "unit_price": null, "strength_mg": 120.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FEBRIMOL ORAL DROPS 20 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 4.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "THERA-LO 3.2G/100ML ORAL SUSP. 100 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 5.0, "pack_count": null, "unit_price": null, "strength_mg": 3200.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "febrile-seizure-simple" }, { "id": 718, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "No dose - referral pathway, no medicine given in primary care", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - The lumbar puncture criteria to rule out meningitis or CNS infection after a febrile seizure are age under 12 months, inadequate Strep pneumoniae/Hib immunization, seizure occurring 2 days after fever onset, or current antibiotic use that may mask meningitis.", "RED FLAG - Counsel that antipyretics (including paracetamol) do not prevent febrile seizure recurrence, so their use should not be framed as seizure prevention.", "Manage the fever with paracetamol, not aspirin.", "A child who has not returned to their neurological baseline - persisting headache, cognitive change or weakness on examination - should prompt a search for a diagnosis other than a febrile seizure.", "A complex febrile seizure needs a full evaluation to rule out structural and infectious causes, including an EEG.", "Omitting lumbar puncture is only safe when the seizure was simple and the child has returned rapidly to baseline.", "Head imaging after a febrile seizure is warranted only for raised intracranial pressure, a focal neurological abnormality, a suspected structural brain defect, an enlarged head, or severe head injury.", "Examine deliberately for the source of the fever and for meningism: bulging red eardrums, red pharynx, enlarged inflamed tonsils, neck stiffness, a bulging or tense fontanelle, and Brudzinski sign.", "Benzodiazepines are not recommended as a preventative measure between febrile episodes." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "febrile-seizure-simple" }, { "id": 717, "generic": "Diazepam", "line": 1, "is_adjunct": true, "form": "injection", "strength_mg": 5.0, "adult_dose": "Not applicable - pediatric entry", "adult_duration": "Single rescue dose", "dose_source": "Egyptian National Drug Formulary, nervous system 2025, diazepam monograph, febrile convulsions (printed p. 12)", "rationale": "Home rescue medication for prolonged seizure (>5 minutes)", "cautions": [ "Indicated ONLY as emergency rescue for seizure lasting >5 minutes.", "There is a risk of respiratory depression; call emergency services immediately if seizure continues after 5 minutes post-diazepam.", "There is no rectal tube among the packs registered here - only ampoules and tablets. Rectal dosing means drawing the injection solution up and instilling it, which is normal practice locally but is worth knowing before you go looking for a preparation that does not exist.", "The formulary's route for a febrile convulsion is intravenous, 0.2-0.4 mg/kg with a second dose after ten minutes if needed, never more than 10 mg in one dose. Where a line can be got, that is the dose to use." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Child 1 month–1 year: 5 mg rectally; Child 1–5 years: 5 mg rectally; Child 6–11 years: 10 mg rectally. Repeat once after 5 minutes if seizure continues. Administer as emergency rescue for seizure lasting >5 minutes. In Egypt, use IV diazepam ampoule content drawn into a syringe (without needle) and instilled rectally", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "1 month to 5 years", "age_min_months": 1, "age_max_months": 71, "dose_text": "5 mg rectally. Repeat once after 5 minutes if the seizure continues." }, { "label": "6 to 11 years", "age_min_months": 72, "age_max_months": 143, "dose_text": "10 mg rectally. Repeat once after 5 minutes if the seizure continues." } ], "peds_doses": null, "brands": [ { "trade_name": "VALPAM 5 MG/ML 3 AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMOUN", "price_egp": 6.0, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "febrile-seizure-simple" } ] }