{ "schema_version": 1, "kind": "condition", "id": "g6pd-deficiency", "name": "Glucose-6-Phosphate Dehydrogenase Deficiency (Favism)", "category": "chronic", "sources": "Egyptian National Drug Formulary - Blood Disorder Medications 2025 (folic acid monograph) · Paracetamol 500mg SmPC (https://www.medicines.org.uk/emc/product/5192/smpc) · WHO Working Group on G6PD Deficiency 2022", "review_status": "reviewed", "verified_against": "Egyptian National Drug Formulary - Blood Disorder Medications 2025 (folic acid monograph) · Paracetamol 500mg SmPC (https://www.medicines.org.uk/emc/product/5192/smpc) · Glucose-6-Phosphate Dehydrogenase Deficiency - disease-level clinical article (g6pd-deficiency-full.txt)", "verified_date": "2026-08", "treatments": [ { "id": 767, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Glucose-6-Phosphate Dehydrogenase Deficiency - disease-level clinical article (g6pd-deficiency-full.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Methylene blue is contraindicated in G6PD deficiency." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "g6pd-deficiency" }, { "id": 766, "generic": "Folic acid", "line": 1, "is_adjunct": true, "form": "oral.solid", "strength_mg": 5.0, "adult_dose": "5 mg once daily during acute post-haemolytic recovery", "adult_duration": null, "dose_source": "Egyptian National Drug Formulary - Blood Disorder Medications 2025 (folic acid monograph)", "rationale": "Vitamin cofactor for red-cell production, used during the acute recovery phase after a haemolytic episode to support the marrow's replacement of destroyed red cells; it does not treat the underlying enzyme deficiency or prevent further haemolysis, which relies on strict avoidance of oxidative triggers.", "cautions": [ "Supports active erythropoiesis following an oxidative haemolytic episode.", "Not required continuously in asymptomatic individuals without ongoing haemolysis.", "Strictly avoid oxidative drugs: cotrimoxazole, nitrofurantoin, dapsone, primaquine, rasburicase, methylene blue, and fava beans.", "Patients with vitamin B12 deficiency should not be treated with folic acid unless administered with adequate amounts of hydroxocobalamin, as it can mask the symptoms while the subacute irreversible damage to the nervous system will continue." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Child 1-12 years: 2.5 mg-5 mg once daily. Child 12-18 years: 5-10 mg once daily.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "1 to 12 years", "age_min_months": 12, "age_max_months": 143, "dose_text": "2.5 to 5 mg once daily" }, { "label": "12 to 18 years", "age_min_months": 144, "age_max_months": 216, "dose_text": "5 to 10 mg once daily" } ], "peds_doses": null, "brands": [ { "trade_name": "FOLIC ACID (EL NILE) 5 MG 50 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 26.25, "pack_count": 50, "unit_price": 0.53, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FOLIC ACID (MEMPHIS) 5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 15.75, "pack_count": 30, "unit_price": 0.53, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FOLICINAD 5 MG 50 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "INAD PHARMA", "price_egp": 50.0, "pack_count": 50, "unit_price": 1.0, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FOLIC ACID (EIPICO) 5 MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 24.0, "pack_count": 20, "unit_price": 1.2, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FOLIC ACID (EL NILE) 5 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 36.0, "pack_count": 30, "unit_price": 1.2, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FOLIRAQ 5000 MCG 30 CAPSULES", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HP PHARMA", "price_egp": 45.0, "pack_count": 30, "unit_price": 1.5, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FOLIDDOX 400 MCG / 5 ML LIQUID 150 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MADDOX PHARMA", "price_egp": 150.0, "pack_count": null, "unit_price": null, "strength_mg": 0.4, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "g6pd-deficiency" } ] }