{ "schema_version": 1, "kind": "condition", "id": "glaucoma-continuing", "name": "Glaucoma (continuing therapy, open-angle)", "category": "chronic", "sources": "Latanoprost 50 micrograms/ml Eye Drops Solution SmPC sections 4.2 and 4.4 (eMC product 2983) · Timoptol 0.5% w/v Eye Drops Solution SmPC sections 4.1, 4.2, 4.3 and 4.4 (eMC product 10611) · Tripathy K, Zeppieri M. Open Angle Glaucoma. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan- . [Updated 2024 Mar 7]. Bookshelf ID: NBK441887. PMID: 28722917.", "review_status": "reviewed", "verified_against": "Latanoprost 50 micrograms/ml Eye Drops Solution SmPC sections 4.2 and 4.4 (eMC product 2983) · Timoptol 0.5% w/v Eye Drops Solution SmPC sections 4.1, 4.2, 4.3 and 4.4 (eMC product 10611) · Tripathy K, Zeppieri M. Open Angle Glaucoma. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan- . [Updated 2024 Mar 7]. Bookshelf ID: NBK441887. PMID: 28722917.", "verified_date": "2026-08", "treatments": [ { "id": 802, "generic": "Latanoprost", "line": 1, "is_adjunct": false, "form": "eye", "strength_mg": null, "adult_dose": "One drop into the affected eye(s) once daily, in the evening. Do NOT exceed once daily - more frequent use lowers the pressure-reducing effect", "adult_duration": "Long term", "dose_source": "Latanoprost 50 micrograms/ml Eye Drops Solution SmPC sections 4.2 and 4.4 (eMC product 2983)", "rationale": "A prostaglandin analogue, once daily, and the label states the optimal effect is obtained in the evening. No systemic beta-blockade, which is what makes it the easier drop to repeat in a patient with asthma or heart disease.", "cautions": [ "Diagnosis, target pressure and any change of drug are the ophthalmologist's. This entry is for continuing a drop already started and for the questions that arise between visits.", "It permanently darkens the iris in mixed-coloured eyes, usually within the first 8 months. Warn the patient before the first bottle - it is not reversible.", "It lengthens, thickens and darkens the eyelashes, and can make them grow in the wrong direction. This one does reverse on stopping.", "Contact lenses out before the drop, back in no sooner than 15 minutes - the preservative is absorbed by soft lenses.", "Use caution where there is a risk of iritis or uveitis; the label records no experience in active intraocular inflammation." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "The label covers paediatric glaucoma, but a child with glaucoma is under ophthalmology and the drop is their decision, not a primary-care one.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "LATANOSWIX 50MCG/ML EYE DROPS 2.5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CHEMIPHARM", "price_egp": 50.0, "pack_count": null, "unit_price": null, "strength_mg": 0.05, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "XALATREX 50MCG/ML EYE DROPS 2.5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 67.0, "pack_count": null, "unit_price": null, "strength_mg": 0.05, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "IOPROST 50MCG/ML EYE DROPS 3 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA > ORCHIDIA", "price_egp": 81.0, "pack_count": null, "unit_price": null, "strength_mg": 0.05, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "IOPROST 50MCG/ML EYE DROPS 30 X 0.2 ML SDU", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORCHIDIA", "price_egp": 126.0, "pack_count": null, "unit_price": null, "strength_mg": 0.05, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "XALATAN 50MCG/ML EYE DROPS 2.5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER > VIATRIS EGYPT", "price_egp": 228.0, "pack_count": null, "unit_price": null, "strength_mg": 0.05, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "glaucoma-continuing" }, { "id": 803, "generic": "Timolol", "line": 2, "is_adjunct": false, "form": "eye", "strength_mg": null, "adult_dose": "One drop of the 0.25% solution into the affected eye twice daily. If the response is inadequate, one drop of the 0.5% solution into each affected eye twice daily", "adult_duration": "Long term", "dose_source": "Timoptol 0.5% w/v Eye Drops Solution SmPC sections 4.1, 4.2, 4.3 and 4.4 (eMC product 10611)", "rationale": "A topical beta blocker for raised intraocular pressure in ocular hypertension and chronic open-angle glaucoma. The label starts at 0.25% and steps up to 0.5% only if that is not enough - the stronger drop is not the starting drop.", "cautions": [ "THIS IS A BETA BLOCKER AND IT IS ABSORBED SYSTEMICALLY FROM THE EYE. The label states the same cardiovascular and pulmonary reactions seen with oral beta blockers may occur.", "CONTRAINDICATED in asthma or a history of asthma, and in severe COPD.", "CONTRAINDICATED in sinus bradycardia, sick sinus syndrome, sino-atrial block, second- or third-degree heart block not controlled by a pacemaker, overt cardiac failure and cardiogenic shock.", "It can mask the warning signs of hypoglycaemia in a patient on insulin.", "Diagnosis, target pressure and any change of drug are the ophthalmologist's. This entry is for continuing a drop already started and for the questions that arise between visits.", "In angle-closure glaucoma the label says it must be used with a miotic and not alone.", "Press on the inner corner of the eye (nasolacrimal occlusion) or close eyelids for 2 minutes after instillation to reduce systemic absorption." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not a primary-care decision in a child. Systemic beta-blockade from eye drops is proportionally greater in a small child.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "CUSIMOLOL 0.5% EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > ALCON", "price_egp": 10.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TIMOGEL 0.1% EYE GEL 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORCHIDIA PHARMACEUTICAL INDUSTRIES > ORCHIDIA", "price_egp": 12.6, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TARGOTIMOL 0.5% EYE DROPS 10*0.4 ML SDU", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL ADVANCED PHARMACEUTICALS (GAP) > MONOPHARMA PHARMACEUTICALS", "price_egp": 18.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TIMOLOL MALEATE 0.5% EYE DROPS 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 19.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "glaucoma-continuing" } ] }