{ "schema_version": 1, "kind": "condition", "id": "gonorrhoea", "name": "Gonorrhoea (Uncomplicated Genital Infection)", "category": "infectious", "sources": "CDC STI Treatment Guidelines 2021 · WHO Guidelines for the Treatment of Neisseria gonorrhoeae 2016 · BASHH UK National Guideline for the Management of Infection with Neisseria gonorrhoeae, 2025, sections 11.2 and 11.3 · CDC STI Treatment Guidelines 2021 (paediatric dosing) · Gonorrhea - StatPearls - NCBI Bookshelf (NBK558903)", "review_status": "reviewed", "verified_against": "BASHH UK National Guideline for the Management of Infection with Neisseria gonorrhoeae, 2025, sections 11.2 and 11.3 · CDC STI Treatment Guidelines 2021 (paediatric dosing)", "verified_date": "2026-08", "treatments": [ { "id": 810, "generic": "Ceftriaxone", "line": 1, "is_adjunct": false, "form": "injection", "strength_mg": 1000.0, "adult_dose": "1 g intramuscularly as a single dose. Reconstitute in 1% lidocaine - a 1 g IM injection is painful and that is a real reason people refuse it. If chlamydia has not been excluded, add doxycycline 100 mg twice daily for 7 days", "adult_duration": "Single dose", "dose_source": "BASHH UK National Guideline for the Management of Infection with Neisseria gonorrhoeae, 2025, sections 11.2 and 11.3", "rationale": "BASHH raised this from 500 mg to 1 g. Ceftriaxone still works - most infections with reduced susceptibility are still cleared at 1 g, and the few reported failures have been pharyngeal. Egypt sells 39 different 1 g vials and the cheapest is 22 EGP, so the higher dose costs almost nothing here.", "cautions": [ "Perform test-of-cure 14 days after treatment if symptoms persist or if pharyngeal gonorrhoea is suspected.", "Treat all sexual partners from the past 60 days.", "Screen for co-existing STIs including Chlamydia trachomatis, HIV, and syphilis.", "The paediatric figures here are CDC's, not BASHH's - the BASHH guideline is written for people aged 16 and over." ], "peds_mgkg_low": 25.0, "peds_mgkg_high": 50.0, "peds_max_mg": 250.0, "peds_basis": "dose", "peds_unit": "mg", "peds_note": "Children under 45 kg: 25-50 mg/kg IM single dose, maximum 250 mg - not the adult 500 mg. Neonatal gonococcal ophthalmia requires emergency parenteral treatment under paediatric specialist care.", "peds_min_weight_kg": null, "peds_max_weight_kg": 45.0, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 250, "high_mg": 250, "capped": true }, { "weight_kg": 20, "low_mg": 250, "high_mg": 250, "capped": true }, { "weight_kg": 30, "low_mg": 250, "high_mg": 250, "capped": true }, { "weight_kg": 40, "low_mg": 250, "high_mg": 250, "capped": true } ], "brands": [ { "trade_name": "ZOXIDEL 1 GM PD. FOR I.M. INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > DELTA PHARMA", "price_egp": 22.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CEFTRIAXONE SODIUM 1 GM I.M.VIAL (KAHIRA)", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 29.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZOXIDEL 1 GM PD. FOR I.V. INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > DELTA PHARMA", "price_egp": 29.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "WINTRIAXONE 1 GM PD. FOR I.V INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 48.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VOTRIAXONE 1 GM I.M VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CHEMIPHARM", "price_egp": 56.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "OFRAMAX 1 GM I.M. VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > SUN PHARMA EGYPT LIMITED", "price_egp": 71.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TRIAXONE 1 GM I.M. VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "TABUK PHARMACEUTICAL MANUFACTURING COMPANY > TABUK PHARMA", "price_egp": 106.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TRIAXONE 1 GM I.V VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "TABUK PHARMACEUTICAL MANUFACTURING COMPANY > TABUK PHARMA", "price_egp": 106.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "gonorrhoea" }, { "id": 811, "generic": "Cefixime", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 400.0, "adult_dose": "400 mg orally, then a second 400 mg 6-12 hours later, PLUS azithromycin 2 g orally as a single dose (or 1 g then another 1 g 6-12 hours later, which is easier on the stomach). Add doxycycline 100 mg twice daily for 7 days if chlamydia is not excluded", "adult_duration": "two cefixime doses 6-12 hours apart, on one day", "dose_source": "BASHH UK National Guideline for the Management of Infection with Neisseria gonorrhoeae, 2025, sections 11.2 and 11.3", "rationale": "Only when an intramuscular injection is genuinely contraindicated AND susceptibility results are in hand. The single 800 mg dose is gone: BASHH split it into two 400 mg doses because what clears the organism is the time the free drug stays above the MIC, not the peak - and a second dose achieves that where a bigger single one does not.", "cautions": [ "Give the second cefixime dose 6-8 hours after the first, and no later than 12. Past 12 hours there is no benefit in taking it, and no benefit in restarting.", "Never cefixime alone for pharyngeal infection - it has failed as monotherapy there, which is why the azithromycin is not optional.", "Cure rates are lower for pharyngeal gonococcal infection compared to IM ceftriaxone; test-of-cure is mandatory.", "Contraindicated in patients with severe cephalosporin or anaphylactic penicillin allergy." ], "peds_mgkg_low": 8.0, "peds_mgkg_high": 8.0, "peds_max_mg": 400.0, "peds_basis": "dose", "peds_unit": "mg", "peds_note": "Children <45 kg: 8 mg/kg single oral dose (max 400 mg). Specialist pediatric consultation required.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 80, "high_mg": 80, "capped": false }, { "weight_kg": 20, "low_mg": 160, "high_mg": 160, "capped": false }, { "weight_kg": 30, "low_mg": 240, "high_mg": 240, "capped": false }, { "weight_kg": 40, "low_mg": 320, "high_mg": 320, "capped": false } ], "brands": [ { "trade_name": "HEBIXIME 400MG 5 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SHIFA MEDICAL PRODUCTS > GLORY MEDICAL", "price_egp": 60.0, "pack_count": 5, "unit_price": 12.0, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "XIMACEF 400MG 5 CAPSULE", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 63.0, "pack_count": 5, "unit_price": 12.6, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "WIDEPREX 400 MG 5 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "BIOMED PHARMACEUTICALS", "price_egp": 104.0, "pack_count": 5, "unit_price": 20.8, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SUPRAX 400 MG 5 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA > HIKMA PHARMA", "price_egp": 159.0, "pack_count": 5, "unit_price": 31.8, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VIODRILNEX 100MG/5ML SUSP. 30ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "BADR PHARMA > HOCHSTER PHARMACEUTICAL INDUSTRIES", "price_egp": 21.5, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "CEFABRUM 100MG/5ML SUSP. 60ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALFACURE PHARMACEUTICALS", "price_egp": 27.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "gonorrhoea" }, { "id": 812, "generic": "Azithromycin", "line": 3, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "2 g by mouth as a single dose, taken with the gentamicin injection", "adult_duration": "single dose", "dose_source": "Gonorrhea - StatPearls - NCBI Bookshelf (NBK558903)", "rationale": "The second half of the fallback regimen for the patient who cannot have a cephalosporin; neither drug clears gonorrhoea reliably on its own at these doses.", "cautions": [ "Given only together with the gentamicin injection, as one treatment.", "Azithromycin can prolong the QT interval; take care in cardiac disease or with other QT-prolonging drugs.", "Arrange a test of cure, because this is a fallback regimen rather than the recommended one." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "No paediatric dose for this regimen in the sources opened.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "AZATRIBACT 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RIVA PHARMA S.A.E.", "price_egp": 13.5, "pack_count": 3, "unit_price": 4.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GIGAZOCIN 500MG 5 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > PIONEER", "price_egp": 27.5, "pack_count": 5, "unit_price": 5.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SYSTYMYCIN 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > NOVELL PHARMA", "price_egp": 21.5, "pack_count": 3, "unit_price": 7.17, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZITHROMASH 500 MG 3 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 48.0, "pack_count": 3, "unit_price": 16.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZALIDE 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UP PHARMA", "price_egp": 52.0, "pack_count": 3, "unit_price": 17.33, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZROLID 500 MG 6 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 126.0, "pack_count": 6, "unit_price": 21.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZERAMERATE 500 MG", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > GAMMA PHARMA", "price_egp": 28.5, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DISTABCIN 500 MG 3 DISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI", "price_egp": 43.5, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHRODOSE 100MG/5ML SUSP. 15ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL-OBOUR > AVERROES PHARMA-EGYPT", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHROPHATE 200MG/5ML SUSP. 15ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANO PHARMA > NOVELL PHARMA", "price_egp": 12.75, "pack_count": null, "unit_price": null, "strength_mg": 200.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "gonorrhoea" }, { "id": 814, "generic": "Gentamicin", "line": 3, "is_adjunct": false, "form": "injection", "strength_mg": null, "adult_dose": "240 mg as a single intramuscular dose, given together with azithromycin 2 g orally as a single dose", "adult_duration": "single dose", "dose_source": "Gonorrhea - StatPearls - NCBI Bookshelf (NBK558903)", "rationale": "Ceftriaxone and cefixime are both cephalosporins, so the patient with a severe cephalosporin allergy needs another route. This is the one the article gives for that patient, and it is one injection given in the clinic rather than a hospital regimen.", "cautions": [ "The gentamicin is never given on its own here - the oral azithromycin is part of the same single treatment and one without the other will not clear the infection.", "Egyptian gentamicin ampoules are smaller than this dose, so it has to be made up from more than one ampoule.", "Avoid in significant renal impairment and in anyone with known aminoglycoside hearing loss.", "Only use this route when the cephalosporin allergy is genuinely severe; a vague penicillin history is not a reason to leave ceftriaxone behind.", "Arrange a test of cure, because this is a fallback regimen rather than the recommended one." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "No paediatric dose for this regimen in the sources opened.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "REFOBACIN 40MG 3 AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE > MERCK KGAA F.R.GERMANY", "price_egp": 6.0, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "REFOBACIN 80MG 3 AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE > MERCK KGAA F.R.GERMANY", "price_egp": 9.0, "pack_count": null, "unit_price": null, "strength_mg": 80.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GENTAMICIN-ALEX 20MG/2ML 6 AMP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EPIGENT 20MG/2ML I.V./I.M. 3 AMPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 24.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GENTAMICIN-ALEX 80MG/2ML 3 AMP. I.M/I.V INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 52.5, "pack_count": null, "unit_price": null, "strength_mg": 80.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EPIGENT 80MG/2ML I.M./I.V. 3 AMPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 54.0, "pack_count": null, "unit_price": null, "strength_mg": 80.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GARAMYCIN 20MG/2ML 6 AMPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 66.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GARAMYCIN 40MG/ML 6 AMPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 72.0, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "gonorrhoea" }, { "id": 813, "generic": "Doxycycline", "line": 1, "is_adjunct": true, "form": "oral.solid", "strength_mg": 100.0, "adult_dose": "100 mg twice a day", "adult_duration": "7 days", "dose_source": "Gonorrhea - StatPearls - NCBI Bookshelf (NBK558903)", "rationale": "Gonorrhoea and chlamydia are caught together often enough that the article treats both unless chlamydia has been ruled out by a test. Covering only the gonococcus leaves the second half of the standard visit undone.", "cautions": [ "Do not give this in pregnancy - the article substitutes a single oral dose of azithromycin.", "Skip it only if a chlamydia test has actually come back negative, not because the patient looks low risk.", "Warn about sun sensitivity, and have the capsule taken upright with plenty of water so it does not lodge in the gullet.", "Treat the sexual partner as well, or the patient is reinfected." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "No paediatric dose for this co-treatment in the sources opened.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "FARCODOXIN 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 11.0, "pack_count": 10, "unit_price": 1.1, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXY M.R.100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ADWIA", "price_egp": 12.0, "pack_count": 10, "unit_price": 1.2, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GRANUDOXY 100MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS > PIERRE FRANCE", "price_egp": 12.0, "pack_count": 10, "unit_price": 1.2, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXYDOX 100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 23.0, "pack_count": 10, "unit_price": 2.3, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DOXYMYCIN 100 MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NILE.", "price_egp": 30.0, "pack_count": 10, "unit_price": 3.0, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TABOCINE 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "TABUK PHARMACEUTICAL MANUFACTURING COMPANY > TABUK PHARMA", "price_egp": 46.0, "pack_count": 10, "unit_price": 4.6, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VIBRAMYCIN 100MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER", "price_egp": 65.0, "pack_count": 10, "unit_price": 6.5, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "gonorrhoea" } ] }