{ "schema_version": 1, "kind": "condition", "id": "gord-in-infants", "name": "Gastro-Oesophageal Reflux Disease in Infants", "category": "chronic", "sources": "Gastro-oesophageal reflux disease in children and young people: diagnosis and management (NICE Guideline NG1, 2019) - NCBI Bookshelf - https://www.ncbi.nlm.nih.gov/books/NBK552673/ · NASPGHAN/ESPGHAN Pediatric Gastroesophageal Reflux Clinical Practice Guidelines 2018 · Rosen R, Vandenplas Y, Singendonk M, Cabana M, DiLorenzo C, Gottrand F, Gupta S, Langendam M, Staiano A, Thapar N, Tipnis N, Tabbers M. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of NASPGHAN and ESPGHAN. J Pediatr Gastroenterol Nutr. 2018 Mar;66(3):516-554. doi:10.1097/MPG.0000000000001889. PMCID: PMC5958910.", "review_status": "reviewed", "verified_against": "NASPGHAN/ESPGHAN Pediatric Gastroesophageal Reflux Clinical Practice Guidelines 2018", "verified_date": "2026-08", "treatments": [ { "id": 815, "generic": "Alginate + Feed Thickener", "line": 1, "is_adjunct": false, "form": "oral.liquid", "strength_mg": null, "adult_dose": "Not applicable - pediatric entry", "adult_duration": "2-4 weeks trial", "dose_source": "NASPGHAN/ESPGHAN Pediatric Gastroesophageal Reflux Clinical Practice Guidelines 2018", "rationale": "First-line conservative management for symptomatic infant reflux after position and volume adjustments", "cautions": [ "Uncomplicated 'happy spitters' require reassurance and positioning, NOT acid suppression.", "Do not use alginates in preterm infants or those with diarrhoea/fever (risk of hypernatremia).", "Ensure formula is not over-concentrated when using thickeners." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Breastfed infants: mix 1 sachet in 5 mL cooled boiled water and give after feeding. Formula-fed: add 1 sachet per 115 mL formula", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "gord-in-infants" }, { "id": 816, "generic": "Omeprazole", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 10.0, "adult_dose": "Not applicable - pediatric entry", "adult_duration": "4-8 weeks trial", "dose_source": "NASPGHAN/ESPGHAN Pediatric Gastroesophageal Reflux Clinical Practice Guidelines 2018", "rationale": "Proton pump inhibitor reserved for infants with confirmed, complicated gastro-oesophageal reflux disease (e.g. poor weight gain, oesophagitis) rather than simple regurgitation, given the guideline's caution about infection and microbiome risks with unnecessary acid suppression in this age group.", "cautions": [ "Acid suppressants are NOT indicated for uncomplicated regurgitation.", "There is an increased risk of gastroenteritis, CAP, and altered gut microbiome in infants on long-term PPIs.", "Re-evaluate after 4-8 weeks and taper off." ], "peds_mgkg_low": 1.0, "peds_mgkg_high": 1.0, "peds_max_mg": 20.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "1 mg/kg once daily in the morning (max 20 mg) for 4-8 weeks in documented GORD with oesophagitis or severe pain/failure to thrive", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 10, "high_mg": 10, "capped": false }, { "weight_kg": 20, "low_mg": 20, "high_mg": 20, "capped": false }, { "weight_kg": 30, "low_mg": 20, "high_mg": 20, "capped": true }, { "weight_kg": 40, "low_mg": 20, "high_mg": 20, "capped": true } ], "brands": [ { "trade_name": "OMEPAK 10 MG 14 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 14.4, "pack_count": 14, "unit_price": 1.03, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RISEK 10 MG 14 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JULPHAR", "price_egp": 19.2, "pack_count": 14, "unit_price": 1.37, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RISEK 10 MG 7 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JULPHAR", "price_egp": 13.2, "pack_count": 7, "unit_price": 1.89, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HEALSEC 10 MG 14 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "BORG", "price_egp": 32.0, "pack_count": 14, "unit_price": 2.29, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FASTCURE 10 MG 21 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "OCTOBER PHARMA", "price_egp": 60.0, "pack_count": 21, "unit_price": 2.86, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "OMEZ 10MG 14 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 40.0, "pack_count": 14, "unit_price": 2.86, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "gord-in-infants" } ] }