Hand-Foot-and-Mouth Disease

1 g 3 or 4 times daily (max. 4 g daily) x 5-7 days

10-15 mg/kg/dose [child max 500 mg]

(Child 1 month and over: 15 mg/kg 3 or 4 times daily (max. 60 mg/kg daily). Child under 1 month: 10 mg/kg 3 or 4 times daily (max. 40 mg/kg daily).)

MSF Essential Drugs 2024 - paracetamol (oral)

Analgesic and antipyretic used for symptomatic relief of fever, sore throat, and malaise in hand-foot-and-mouth disease, a self-limiting viral illness with no antiviral treatment and managed supportively.

Hand, Foot, and Mouth Disease - disease-level clinical article (hand-foot-and-mouth-clinical.txt)

Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.

400 mg 3 times daily after food x 5-7 days

5-10 mg/kg/dose [child max 400 mg]

(Every 6-8 hours after food;. Child over 3 months: 5 to 10 mg/kg 3 to 4 times daily, maximum 30 mg/kg daily. The suspension's own label caps pain-and-fever use lower still, at 20 mg/kg/day. Never exceed 400 mg in a single dose.)

Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560) for the adult dose: "The recommended dose is 200 mg-400 mg (10-20 ml), up to three times a day as required... do not take more than 1200 mg (60 ml) in any 24 hour period". That label's paediatric section gives weight bands and a 20 mg/kg/day pain-and-fever ceiling but states no mg/kg per dose, so the paediatric 5 to 10 mg/kg per dose is from MSF Essential Drugs 2024 (ibuprofen oral monograph): "Child over 3 months: 5 to 10 mg/kg 3 to 4 times daily (max. 30 mg/kg daily)".

NSAID alternative for pain relief, particularly useful for painful oral ulcers that limit fluid intake; avoided in severe asthma or dehydration.