{
  "schema_version": 1,
  "kind": "condition",
  "id": "hiv-aids-symptomatic",
  "name": "Symptomatic HIV infection / AIDS",
  "category": "chronic",
  "sources": "HIV and AIDS - StatPearls - NCBI Bookshelf (NBK534860) - https://www.ncbi.nlm.nih.gov/books/NBK534860/ · ICPC-3 (WONCA International Classification of Primary Care, 3rd edition) class BD04 - condition scope only, no dose · No dose - referral pathway, no medicine given in primary care",
  "review_status": "reviewed",
  "verified_against": "No dose - referral pathway, no medicine given in primary care",
  "verified_date": "2026-08",
  "treatments": [
    {
      "id": 911,
      "generic": "No drug therapy in primary care (Referral & Advice)",
      "line": 1,
      "is_adjunct": false,
      "form": null,
      "strength_mg": null,
      "adult_dose": "Advanced HIV disease needs urgent referral to a specialist HIV centre for ART and opportunistic-infection management; a GP's main contribution is recognising it, starting co-trimoxazole prophylaxis if there will be a delay reaching the centre, and referring urgently.",
      "adult_duration": "Refer, with advice",
      "dose_source": "No dose - referral pathway, no medicine given in primary care",
      "rationale": "Advanced HIV disease needs urgent referral to a specialist HIV centre for ART and opportunistic-infection management; a GP's main contribution is recognising it, starting co-trimoxazole prophylaxis if there will be a delay reaching the centre, and referring urgently.",
      "cautions": [
        "No medicine is prescribed for this in primary care - this entry is for recognition and referral. Anything given is decided by the service it is referred to.",
        "RED FLAG - Advanced immunosuppression with CD4 count < 200 cells/µL places patients at high risk for opportunistic infections.",
        "RED FLAG - Primary prophylaxis is indicated for CD4 count < 200 cells/µL to prevent Pneumocystis jirovecii and Toxoplasma gondii opportunistic infections.",
        "RED FLAG - Opportunistic infection symptoms (persistent fever, chronic diarrhoea, oral thrush, weight loss, cough), neurological symptoms, severe wasting, or pregnancy."
      ],
      "peds_mgkg_low": null,
      "peds_mgkg_high": null,
      "peds_max_mg": null,
      "peds_basis": null,
      "peds_unit": null,
      "peds_note": "Children follow the same pathway: recognise and refer. No primary-care medicine is implied.",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": null,
      "brands": [],
      "condition_id": "hiv-aids-symptomatic"
    }
  ]
}