{ "schema_version": 1, "kind": "condition", "id": "hypertriglyceridemia", "name": "Hypertriglyceridemia (Severe)", "category": "chronic", "sources": "Lopid (gemfibrozil) 600 mg tablets SmPC sections 4.2-4.5 (eMC product 2261) · Supralip ® 160 mg, film-coated tablet SmPC section 4.2 Posology and method of administration (eMC product 2198)", "review_status": "reviewed", "verified_against": "Lopid (gemfibrozil) 600 mg tablets SmPC sections 4.2-4.5 (eMC product 2261) · Supralip ® 160 mg, film-coated tablet SmPC section 4.2 Posology and method of administration (eMC product 2198) · Hypertriglyceridemia - disease-level clinical article (hypertriglyceridemia-full.txt)", "verified_date": "2026-08", "treatments": [ { "id": 938, "generic": "Fenofibrate", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 160.0, "adult_dose": "160 mg once daily with food", "adult_duration": null, "dose_source": "Supralip ® 160 mg, film-coated tablet SmPC section 4.2 Posology and method of administration (eMC product 2198)", "rationale": "Fibrate that activates PPAR-alpha to lower triglycerides by increasing lipoprotein lipase activity; used in severe hypertriglyceridaemia specifically to reduce the risk of acute pancreatitis.", "cautions": [ "Monitor renal function and transaminases; use caution and monitor muscle symptoms if combined with a statin.", "CONTRAINDICATED in hepatic insufficiency, severe renal insufficiency (eGFR <30 mL/min), and known gallbladder disease.", "If eGFR is between 30 and 59 mL/min per 1.73 m2, the dose of fenofibrate should not exceed 100 mg standard or 67 mg micronized once daily." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist pediatric lipidologist referral", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "LIPANTHYL SUPRA 160MG 30 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MINA PHARM > ABBOTT LABORATORIES", "price_egp": 141.0, "pack_count": 30, "unit_price": 4.7, "strength_mg": 160.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "hypertriglyceridemia" }, { "id": 940, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Hypertriglyceridemia - disease-level clinical article (hypertriglyceridemia-full.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Pancreatitis risk rises sharply at the triglyceride levels this condition entry covers (severe HTG)." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "hypertriglyceridemia" }, { "id": 939, "generic": "Gemfibrozil", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 600.0, "adult_dose": "600 mg twice daily taken 30 minutes before breakfast and dinner", "adult_duration": null, "dose_source": "Lopid (gemfibrozil) 600 mg tablets SmPC sections 4.2-4.5 (eMC product 2261)", "rationale": "Fibrate with the same triglyceride-lowering mechanism as fenofibrate, offered as a second option; avoided in combination with any statin because of a severe interaction risk that does not apply to fenofibrate.", "cautions": [ "CONTRAINDICATED in hepatic impairment, severe renal impairment (eGFR <30 mL/min), and preexisting gallbladder disease.", "Never with simvastatin, and never with rosuvastatin 40 mg - both are contraindicated, not cautioned. The combination causes severe myositis and rhabdomyolysis. Check what statin the patient is already on before writing this.", "Also contraindicated with repaglinide - it drives exposure up and causes severe hypoglycaemia.", "Not in gallstones or any biliary tract disease, past or present, and not in severe renal or in hepatic impairment.", "Periodic blood count determinations are recommended during the first 12 months of gemfibrozil administration." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist use only", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "FIBROPID 600 MG 30 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "BIOPHARM EGYPT", "price_egp": 36.0, "pack_count": 30, "unit_price": 1.2, "strength_mg": 600.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CHOLENORM 600MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEPACO", "price_egp": 13.2, "pack_count": 10, "unit_price": 1.32, "strength_mg": 600.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LOPID 600MG 30 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER", "price_egp": 54.0, "pack_count": 30, "unit_price": 1.8, "strength_mg": 600.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "hypertriglyceridemia" }, { "id": 941, "generic": "Omega-3 fatty acids", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": null, "adult_dose": "3 g to 4 g/day", "adult_duration": null, "dose_source": "Hypertriglyceridemia (Severe) - disease-level clinical article (hypertriglyceridemia-full.txt)", "rationale": "FDA-approved prescription therapy for severe hypertriglyceridemia (>1000 mg/dL) to lower triglyceride levels and reduce acute pancreatitis risk.", "cautions": [ "May increase levels of low-density lipoprotein cholesterol (LDL-C) due to increased conversion of VLDL to LDL (an effect not observed with EPA-only prescription products).", "Gastrointestinal discomfort and fish-like taste are common dose-limiting factors with high doses.", "Because nonprescription products contain variable amounts of EPA and DHA, attention must be paid to the specific constituents when selecting an omega-3 formulation." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "No paediatric dose is stated in the sources held for this drug.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "TOTAL FORTE 30 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HOCHSTER PHARMACEUTICAL INDUSTRIES", "price_egp": 237.0, "pack_count": 30, "unit_price": 7.9, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "OMEGATONEX 500/250 20 CAPS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GRANTY FOOD INDUSTRY FACTORY > INTEGRA PHARMACEUTICALS", "price_egp": 360.0, "pack_count": 20, "unit_price": 18.0, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SHIRE 25 GUMMIES", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEDCARE > MEDICINA MEDICAL LTD.", "price_egp": 110.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SHIRE 50 GUMMIES", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEDCARE > MEDICINA MEDICAL LTD.", "price_egp": 180.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "OMEGA-3 ENRICHED 40 SOFTGELS (ADRIEN GAGNON)", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ADRIEN GAGNON > EGYPHARMA", "price_egp": 650.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FISH OIL 100 SOFTGELS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "OPTIMUM NUTRITION > RAMCO", "price_egp": 800.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "hypertriglyceridemia" } ] }