{
  "schema_version": 1,
  "kind": "condition",
  "id": "immunodeficiency",
  "name": "Immunodeficiency",
  "category": "chronic",
  "sources": "ICPC-3 (WONCA International Classification of Primary Care, 3rd edition) class BD99.00 - condition scope only, no dose · Immunodeficiency Disorders (Primary and Secondary) - StatPearls - NCBI Bookshelf - https://www.ncbi.nlm.nih.gov/books/NBK500027/ · No dose - referral pathway, no medicine given in primary care",
  "review_status": "reviewed",
  "verified_against": "No dose - referral pathway, no medicine given in primary care",
  "verified_date": "2026-08",
  "treatments": [
    {
      "id": 957,
      "generic": "No drug therapy in primary care (Referral & Advice)",
      "line": 1,
      "is_adjunct": false,
      "form": null,
      "strength_mg": null,
      "adult_dose": "Suspect an underlying immunodeficiency in any child or adult presenting with recurrent severe bacterial infections (such as recurrent deep-seated abscesses, two or more serious sinus infections or pneumonias in a year), persistent mucosal candidiasis, failure to thrive, or opportunistic infections. In primary care, obtain a complete blood count with differential, quantitative serum immunoglobulins, and screen for secondary causes including HIV, diabetes, protein-losing enteropathy, and immunosuppressive medication exposure. Avoid administering any live vaccines (such as MMR, rotavirus, or BCG) until an inborn error of immunity has been ruled out, and refer promptly to a clinical immunologist or infectious disease specialist.",
      "adult_duration": "Refer, with advice",
      "dose_source": "No dose - referral pathway, no medicine given in primary care",
      "rationale": "Suspect an underlying immunodeficiency in any child or adult presenting with recurrent severe bacterial infections (such as recurrent deep-seated abscesses, two or more serious sinus infections or pneumonias in a year), persistent mucosal candidiasis, failure to thrive, or opportunistic infections. In primary care, obtain a complete blood count with differential, quantitative serum immunoglobulins, and screen for secondary causes including HIV, diabetes, protein-losing enteropathy, and immunosuppressive medication exposure. Avoid administering any live vaccines (such as MMR, rotavirus, or BCG) until an inborn error of immunity has been ruled out, and refer promptly to a clinical immunologist or infectious disease specialist.",
      "cautions": [
        "No medicine is prescribed for this in primary care - this entry is for recognition and referral. Anything given is decided by the service it is referred to.",
        "RED FLAG - Recurrent, severe, or unusual infections, failure to thrive in a child, opportunistic infections, or a family history of early childhood deaths from infection."
      ],
      "peds_mgkg_low": null,
      "peds_mgkg_high": null,
      "peds_max_mg": null,
      "peds_basis": null,
      "peds_unit": null,
      "peds_note": "Children follow the same pathway: recognise and refer. No primary-care medicine is implied.",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": null,
      "brands": [],
      "condition_id": "immunodeficiency"
    }
  ]
}