# Influenza (seasonal, outpatient)

- Category: infectious
- Review status: reviewed (every claim checked against a document named on this page)
- Sources: TAMIFLU (oseltamivir phosphate) US prescribing information, section 2.2 Recommended Dosage for Treatment of Influenza and Table 1 (DailyMed SetID ee3c9555-60f2-4f82-a760-11983c86e97b) · IDSA Guidelines for Influenza 2019 · MSF Essential Drugs 2024 - paracetamol (oral)
- Verified date: 2026-08

## Verified against

- TAMIFLU (oseltamivir phosphate) US prescribing information, section 2.2 Recommended Dosage for Treatment of Influenza and Table 1 (DailyMed SetID ee3c9555-60f2-4f82-a760-11983c86e97b)
- MSF Essential Drugs 2024 - paracetamol (oral)

## Treatment metadata

- Oseltamivir — 75 mg — oral.solid
- Paracetamol — 500 mg — oral.solid

## Complete treatment card

```text
INFLUENZA (SEASONAL, OUTPATIENT)
Sources: TAMIFLU (oseltamivir phosphate) US prescribing information, section 2.2 Recommended Dosage
         for Treatment of Influenza and Table 1 (DailyMed SetID
         ee3c9555-60f2-4f82-a760-11983c86e97b) · IDSA Guidelines for Influenza 2019 · MSF Essential
         Drugs 2024 - paracetamol (oral)
Review status: REVIEWED against 2 sources listed above  (2026-08)

IS IT THIS? - reference only, to read alongside your own examination
  SYMPTOMS - what the patient reports (3)
    - Patients who had the seasonal vaccine tend to have milder illness and fewer complications
    - Mild illness brings cough, fever, sore throat, muscle aches, headache, a runny nose and red,
      congested eyes  [cough · fever · headache · muscle pain · runny nose · sore throat]
    - A frontal or behind-the-eye headache with light sensitivity or eye pain is a common
      presentation  [eye pain · headache · photophobia]
  SIGNS - what you find (1)
    - Severe disease can progress to breathlessness, a fast heart rate and low blood pressure,
      sometimes needing respiratory support within 48 hours  [breathlessness · hypotension ·
      tachycardia]
  TESTS (6)
    - Diagnosis is usually made clinically during flu season; most cases don't need lab confirmation
    - In high-risk patients treatment shouldn't be held up waiting for test results
    - Rapid or standard molecular PCR assays are preferred, being highly sensitive and specific and
      able to tell influenza A from B
    - Rapid antigen tests give a result within 15 minutes and are highly specific, but only low-to-
      moderately sensitive
    - Viral culture is the most specific option but takes several days, so it doesn't aid rapid
      diagnosis
    - A chest x-ray is obtained in patients with pulmonary symptoms to rule out bacterial pneumonia
  IF NOT THIS - what else fits (3)
    - Acute respiratory distress syndrome, adenovirus, arenaviruses and cytomegalovirus are also on
      the differential
    - Dengue, echovirus infection, hantavirus pulmonary syndrome and HIV infection are also
      considered
    - Legionnaires disease and human parainfluenza virus round out the differential list
  Source  StatPearls "Influenza" - disease-level clinical article
  Status  traced to the source above

1. OSELTAMIVIR                                            [1st line]
   Adult    75 mg twice daily orally (start within 48 hours of symptom onset for maximum benefit) x
            5 days
   Peds     2 weeks to under 1 year: 3 mg/kg per dose twice daily for 5 days, from 2 weeks of age
            1 to 12 years: Twice daily for 5 days by weight: 15 kg or less, 30 mg; 15.1 to 23 kg, 45
            mg; 23.1 to 40 kg, 60 mg; 40.1 kg or more, 75 mg
            (Infants 2 weeks to <1 year: 3 mg/kg/dose twice daily for 5 days. Children 1-12 years
            dosed by weight twice daily for 5 days: 15 kg or less: 30 mg; 15.1-23 kg: 45 mg; 23.1-40
            kg: 60 mg; 40.1 kg or more: 75 mg.)
   Source   TAMIFLU (oseltamivir phosphate) US prescribing information, section 2.2 Recommended
            Dosage for Treatment of Influenza and Table 1 (DailyMed SetID
            ee3c9555-60f2-4f82-a760-11983c86e97b)
   Why      First-line oral neuraminidase inhibitor antiviral registered and widely available in
            Egypt (Tamiflu, Epimiraflu) for high-risk or severe outpatient influenza
   Caution  Start as early as possible, ideally within 48 hours of symptom onset; clinical benefit
            decreases significantly when started after 48h in uncomplicated low-risk cases.
            May cause nausea and vomiting; administration with food improves tolerability.
            Adjust dose in renal impairment (reduce dose if CrCl <60 mL/min).
            Contraindicated in patients with known serious hypersensitivity to oseltamivir.
            Monitor for neuropsychiatric events (confusion, abnormal behavior), particularly in
            pediatric patients.
   Egypt    TAMINIL-N  75 MG 10 CAPS.        EL NILE.           200.00 EGP (20.00/unit)
            EPIMIRAFLU 75 MG 10 CAPS.        EIPICO             202.00 EGP (20.20/unit)
            TAMILAVIR 75 MG 10 CAPS.         EVA PHARMA         242.00 EGP (24.20/unit)
            OSELTAMIVIR 75 MG 10 CAPS.       ARAB CAPS > A...   288.00 EGP (28.80/unit)
            TAMIFLU 75MG 10 CAPS.            F.HOFFMAN LA ...   345.00 EGP (34.50/unit)
            TAMINIL-N 12MG/ML SUSP. 30 ML    EL NILE.           123.50 EGP
                -> ? strength differs, ? different route - not oral solid
            TAMINIL-N 12MG/ML SUSP. 60 ML    EL NILE.           238.00 EGP
                -> ? strength differs, ? different route - not oral solid

2. PARACETAMOL                                            [add-on - not a substitute]
   Adult    500-1000 mg three or four times a day PRN for fever, headache, and myalgia (max 4000
            mg/day) - According to clinical response
   Peds     10-15 mg/kg/dose  [child max 500 mg]
            (Every 4-6 hours PRN (max 60 mg/kg/day or 4000 mg/day) Under 1
            month: 10 mg/kg 3 or 4 times daily, maximum 40 mg/kg/day (MSF
            Essential Drugs 2024).)
            3kg -> 30-45 mg/dose                    4kg -> 40-60 mg/dose
            5kg -> 50-75 mg/dose                    6kg -> 60-90 mg/dose
            7kg -> 70-105 mg/dose                   8kg -> 80-120 mg/dose
            9kg -> 90-135 mg/dose                   10kg -> 100-150 mg/dose
            11kg -> 110-165 mg/dose                 12kg -> 120-180 mg/dose
            13kg -> 130-195 mg/dose                 14kg -> 140-210 mg/dose
            15kg -> 150-225 mg/dose                 16kg -> 160-240 mg/dose
            17kg -> 170-255 mg/dose                 18kg -> 180-270 mg/dose
            19kg -> 190-285 mg/dose                 20kg -> 200-300 mg/dose
            21kg -> 210-315 mg/dose                 22kg -> 220-330 mg/dose
            23kg -> 230-345 mg/dose                 24kg -> 240-360 mg/dose
            25kg -> 250-375 mg/dose                 26kg -> 260-390 mg/dose
            27kg -> 270-405 mg/dose                 28kg -> 280-420 mg/dose
            29kg -> 290-435 mg/dose                 30kg -> 300-450 mg/dose
            31kg -> 310-465 mg/dose                 32kg -> 320-480 mg/dose
            33kg -> 330-495 mg/dose                 34kg -> 340-500 mg/dose (upper capped)
            35kg -> 350-500 mg/dose (upper capped)  36kg -> 360-500 mg/dose (upper capped)
            37kg -> 370-500 mg/dose (upper capped)  38kg -> 380-500 mg/dose (upper capped)
            39kg -> 390-500 mg/dose (upper capped)  40kg -> 400-500 mg/dose (upper capped)
            41kg -> 410-500 mg/dose (upper capped)  42kg -> 420-500 mg/dose (upper capped)
            43kg -> 430-500 mg/dose (upper capped)  44kg -> 440-500 mg/dose (upper capped)
            45kg -> 450-500 mg/dose (upper capped)  46kg -> 460-500 mg/dose (upper capped)
            47kg -> 470-500 mg/dose (upper capped)  48kg -> 480-500 mg/dose (upper capped)
            49kg -> 490-500 mg/dose (upper capped)  50kg -> 500 mg/dose (capped)
   Source   MSF Essential Drugs 2024 - paracetamol (oral)
   Why      Analgesic and antipyretic added to rest and fluids for symptomatic relief of fever,
            headache, and myalgia in influenza; it does not shorten the illness, and aspirin should
            be avoided in children because of Reye syndrome risk.
   Caution  Avoid aspirin (acetylsalicylic acid) in children and adolescents with influenza due to
            the risk of Reye syndrome.
            Do not exceed maximum daily dose (4 g/day in adults) to avoid liver toxicity.
            500 mg is the per-dose ceiling used here for a child. 1000 mg is the adult dose and does
            not belong in a weight calculation - the daily 60 mg/kg limit is the one that binds
            first in any case.
            Administer with caution to patients with hepatic impairment.
   Egypt    FEBRIMOL 500 MG 20 TAB.          PHARCO               3.50 EGP (0.17/unit)
            CETAMOL 500 MG 20 TABS.          MEMPHIS              8.00 EGP (0.40/unit)
            PARACETAMOL-MUP 500MG B.P. 20 TABS. MUP                            13.00 EGP (0.65/unit)
            CETAL 500 MG 20 TABS.            EIPICO              24.00 EGP (1.20/unit)
            ARKADOLOW 500 MG 30 F.C. TABS.   UTOPIA              42.00 EGP (1.40/unit)
            PARAMOL 500MG 20 TAB.            MISR                38.00 EGP (1.90/unit)
            ADOL 500MG 24 CAPLETS            JULPHAR             32.00 EGP
            AUGICETAMIDE 500 MG 20 SACHETS   AUG PHARMA          50.00 EGP
            FEBRIMOL ORAL DROPS 20 ML        PHARCO               4.00 EGP
                -> ? strength differs, ? different route - not oral solid
            THERA-LO 3.2G/100ML ORAL SUSP. 100 ML PHAROPHARMA                               5.00 EGP
                -> ? strength differs, ? different route - not oral solid

Prices are indicative (dataset snapshot 2026-06); verify with the pharmacy.
```

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