{ "schema_version": 1, "kind": "condition", "id": "intermenstrual-pain", "name": "Intermenstrual pain (Mittelschmerz / ovulation pain)", "category": "acute", "sources": "Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560) · MSF Essential Drugs 2024 - paracetamol (oral) · Brott NR, Le JK. Mittelschmerz. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Updated 2023 May 1. Bookshelf ID: NBK549822; PMID: 31747229.", "review_status": "reviewed", "verified_against": "MSF Essential Drugs 2024 - paracetamol (oral) · Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560) · Brott NR, Le JK. Mittelschmerz. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Updated 2023 May 1. Bookshelf ID: NBK549822; PMID: 31747229.", "verified_date": "2026-08", "treatments": [ { "id": 999, "generic": "Paracetamol", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "1 g three or four times daily, maximum 4 g in 24 hours", "adult_duration": "As needed for pain or fever", "dose_source": "MSF Essential Drugs 2024 - paracetamol (oral)", "rationale": "Symptomatic relief only; it does not treat the cause. The dose is MSF's, under its mild-pain indication: an adult takes 1 g either 3 or 4 times a day, with a daily ceiling of 4 g. The dose claim holds and the indication claim does not, because no disease-level document here recommends an analgesic for mittelschmerz.", "cautions": [ "NO DOCUMENT HELD HERE RECOMMENDS AN ANALGESIC FOR THIS CONDITION. The card's own cited article (StatPearls, Mittelschmerz, NBK549822) was opened and read in full: it has no management section, names no analgesic, and the single treatment sentence in it points at an oral contraceptive, not at a painkiller. This dose is a general analgesic dose for mild pain, offered because the pain is real, not because a source recommends this drug for this diagnosis.", "The article's own view of the course: the pain usually settles inside three to twelve hours. The exception is the woman who has had ovarian surgery, in whom it can carry on until her period starts. A short analgesic course is all that should be needed.", "Relief only - it does not treat what is causing the pain or fever.", "Check every other product the patient is taking for paracetamol; combination cold and flu preparations are the usual route to an accidental overdose.", "Reduce the dose in significant liver disease, chronic alcohol use, or low body weight.", "RED FLAG - Pain lasting well beyond the usual day or two, or fever or abnormal vaginal bleeding accompanying the pain (consider ectopic pregnancy or pelvic infection instead)." ], "peds_mgkg_low": 15.0, "peds_mgkg_high": 15.0, "peds_max_mg": 500.0, "peds_basis": "dose", "peds_unit": "mg", "peds_note": "Child 1 month and over: 15 mg/kg per dose, 3 or 4 times daily, maximum 60 mg/kg daily. Child under 1 month: 10 mg/kg per dose, 3 or 4 times daily, maximum 40 mg/kg daily. MSF's own weight table gives one 500 mg tablet three times daily from 30 kg to under 50 kg, so 500 mg is the per-dose ceiling; the 60 mg/kg daily total still applies.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 150, "high_mg": 150, "capped": false }, { "weight_kg": 20, "low_mg": 300, "high_mg": 300, "capped": false }, { "weight_kg": 30, "low_mg": 450, "high_mg": 450, "capped": false }, { "weight_kg": 40, "low_mg": 500, "high_mg": 500, "capped": true } ], "brands": [ { "trade_name": "FEBRIMOL 500 MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 3.5, "pack_count": 20, "unit_price": 0.17, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CETAMOL 500 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 8.0, "pack_count": 20, "unit_price": 0.4, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PARACETAMOL-MUP 500MG B.P. 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 13.0, "pack_count": 20, "unit_price": 0.65, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CETAL 500 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 24.0, "pack_count": 20, "unit_price": 1.2, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ARKADOLOW 500 MG 30 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UTOPIA", "price_egp": 42.0, "pack_count": 30, "unit_price": 1.4, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PARAMOL 500MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR", "price_egp": 38.0, "pack_count": 20, "unit_price": 1.9, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ADOL 500MG 24 CAPLETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "JULPHAR", "price_egp": 32.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AUGICETAMIDE 500 MG 20 SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AUG PHARMA", "price_egp": 50.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FEBRIMOL ORAL DROPS 20 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 4.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "THERA-LO 3.2G/100ML ORAL SUSP. 100 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 5.0, "pack_count": null, "unit_price": null, "strength_mg": 3200.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "intermenstrual-pain" }, { "id": 1000, "generic": "Ibuprofen", "line": 1, "is_adjunct": true, "form": "oral.solid", "strength_mg": 400.0, "adult_dose": "200 to 400 mg up to three times a day, at least 4 hours between doses, maximum 1200 mg in 24 hours", "adult_duration": "Short-term use only; the shortest effective course", "dose_source": "Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560)", "rationale": "An anti-inflammatory analgesic for the pain. The row once read 200 to 400 mg by mouth every 6 to 8 hours as needed, which permits four doses a day, where the label it cites permits three. The label's own figures are 200 mg to 400 mg - 10 to 20 ml - up to three times daily as required, at least four hours apart, and never more than 1200 mg or 60 ml within any 24 hour period. The daily maximum was already right. The citation was also rewritten from a bare URL to the label's name, which is the same document under the form docs/SOURCES.md asks for.", "cautions": [ "NO DOCUMENT HELD HERE RECOMMENDS AN ANALGESIC FOR THIS CONDITION. The card's own cited article (StatPearls, Mittelschmerz, NBK549822) was opened and read in full: it has no management section, names no analgesic, and the single treatment sentence in it points at an oral contraceptive, not at a painkiller. This dose is a general analgesic dose for mild pain, offered because the pain is real, not because a source recommends this drug for this diagnosis.", "The label's own indication is symptomatic - it is licensed for mild to moderate muscle pain, for fever following immunisation, for headache and earache, for dental pain, and for backache. It does not name this condition.", "Relief only - it does not treat what is causing the pain.", "Take with or after food, and give gastroprotection if it is needed for more than a short course or the patient is over 65.", "Avoid in dehydration and in anyone not drinking - the kidney risk is highest there." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Label verbatim: \"For pain and fever 20 mg/kg/day in divided doses (including OTC use).\" The label's age bands for the 100 mg/5 ml suspension are 3-6 months 2.5 ml three times daily, 6-12 months 2.5 ml three to four times daily, 1-4 years 5 ml three times daily, 4-7 years 7.5 ml three times daily, 7-12 years 10 ml three times daily. Not to be given under 3 months.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "3 to 5 months", "age_min_months": 3, "age_max_months": 5, "dose_text": "2.5 mL of the 100 mg/5 ml suspension three times daily. Not under 3 months." }, { "label": "6 to 11 months", "age_min_months": 6, "age_max_months": 11, "dose_text": "2.5 mL three to four times daily" }, { "label": "1 to 3 years", "age_min_months": 12, "age_max_months": 47, "dose_text": "5 ml three times daily" }, { "label": "4 to 6 years", "age_min_months": 48, "age_max_months": 83, "dose_text": "7.5 ml three times daily" }, { "label": "7 to 11 years", "age_min_months": 84, "age_max_months": 143, "dose_text": "10 ml three times daily" } ], "peds_doses": null, "brands": [ { "trade_name": "DAJUANOFEN 400 MG 20 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "COPAD PHARMA", "price_egp": 5.0, "pack_count": 20, "unit_price": 0.25, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLABU 400MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DELTA PHARMA", "price_egp": 3.75, "pack_count": 10, "unit_price": 0.38, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NOVA-PROFEN 400MG 30 F.C. TABLETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 12.75, "pack_count": 30, "unit_price": 0.42, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "IBUPROFEN 400 MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 6.0, "pack_count": 10, "unit_price": 0.6, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MAFO 400 MG 30 F.C.TABS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 42.0, "pack_count": 30, "unit_price": 1.4, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BRUFEN 400 MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA > ABBOTT LABORATORIES", "price_egp": 78.0, "pack_count": 30, "unit_price": 2.6, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PROFUSOL 400MG 20 S.G CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EUROPEAN EGYPTIAN PHARM. IND.", "price_egp": 31.0, "pack_count": null, "unit_price": null, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANALGIPROF 400 MG 25 SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EVA PHARMA", "price_egp": 37.5, "pack_count": null, "unit_price": null, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NOVA-PROFEN 100MG/5ML ORAL SUSP. 100ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 2.25, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "BRUFEMOL-N SUSP. 60 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 4.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "intermenstrual-pain" } ] }