{ "schema_version": 1, "kind": "condition", "id": "intestinal-helminths", "name": "Intestinal helminths", "category": "infectious", "sources": "CDC Yellow Book 2024 · DailyMed Mebendazole Chewable Tablet Package Insert, SetID 211116b4-2394-47c0-8438-bb4e578f2441 · Egyptian National Drug Formulary - Antimicrobial 2023 (ivermectin monograph) · WHO Human Helminthiasis 2017", "review_status": "reviewed", "verified_against": "DailyMed Mebendazole Chewable Tablet Package Insert, SetID 211116b4-2394-47c0-8438-bb4e578f2441 · Egyptian National Drug Formulary - Antimicrobial 2023 (ivermectin monograph) · WHO Human Helminthiasis 2017 · Ascariasis - StatPearls disease-level clinical article, filed as intestinal-helminths-clinical.txt", "verified_date": "2026-08", "treatments": [ { "id": 1013, "generic": "Mebendazole", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 100.0, "adult_dose": "500 mg single dose (WHO mass chemotherapy) or 100 mg twice daily for 3 days (clinical treatment of specific helminths)", "adult_duration": "3 days", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (mebendazole monograph): \"Dosing: Adult, Adolescents and children > 2 years ... Oral: 100 mg twice daily for 3 days or 500 mg as a single dose\". The formulary treats from 2 years; the from-12-months age floor shown here is WHO Human Helminthiasis 2017, which is not held in this corpus. The DailyMed mebendazole record is a bulk drug-substance listing with no posology.", "rationale": "Benzimidazole anthelmintic that blocks glucose uptake in the parasite by disrupting its microtubules, starving and killing intestinal worms. Standard first-line agent for pinworm and other common intestinal helminths.", "cautions": [ "Contraindicated in 1st trimester of pregnancy.", "For pinworm, treat all household members and repeat in 14 days.", "Chew or crush tablets for young children." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Same as adult dose for children over 1 year: 500 mg single dose or 100 mg twice daily for 3 days", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "Over 1 year", "age_min_months": 13, "age_max_months": 216, "dose_text": "500 mg single dose OR 100 mg twice daily for 3 days (same as adult dose)" } ], "peds_doses": null, "brands": [ { "trade_name": "MEBAMOX 100MG 6 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NASR", "price_egp": 3.25, "pack_count": 6, "unit_price": 0.54, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PENTALMIN 100MG 6 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 3.5, "pack_count": 6, "unit_price": 0.58, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VERMIN 100MG 6 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 8.0, "pack_count": 6, "unit_price": 1.33, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANTIVER 100MG 20*6 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 200.0, "pack_count": 6, "unit_price": 33.33, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANTHELMIN 100MG/5ML SUSP. 30ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 3.5, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "PERMAX 100MG/5ML SUSP. 30ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 10.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "intestinal-helminths" }, { "id": 1014, "generic": "Albendazole", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 400.0, "adult_dose": "400 mg single dose with fatty meal (or 400 mg daily for 3 days)", "adult_duration": "single-dose", "dose_source": "WHO Human Helminthiasis 2017", "rationale": "Benzimidazole anthelmintic with the same microtubule-disrupting, glucose-starving mechanism as mebendazole, and a broader spectrum against intestinal worms; a WHO-recommended alternative first-line option.", "cautions": [ "Contraindicated in pregnancy - verify non-pregnant status.", "Take with fatty food to enhance absorption.", "Abdominal pain and diarrhea may occur during worm expulsion." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "400 mg single dose over 2 years, 200 mg for 1-2 years", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "1 to 2 years", "age_min_months": 12, "age_max_months": 23, "dose_text": "200 mg as a single dose" }, { "label": "Over 2 years", "age_min_months": 24, "age_max_months": 216, "dose_text": "400 mg as a single dose" } ], "peds_doses": null, "brands": [ { "trade_name": "ALBENDAZOLE 400 MG 6 TABS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARMA CURE PHARMACEUTICALS > PHARMA CURE", "price_egp": 46.0, "pack_count": 6, "unit_price": 7.67, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANTIZOLE 100MG/5ML SUSP. 30ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 19.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ALZENTAL 20MG/ML SUSP. 20ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 21.0, "pack_count": null, "unit_price": null, "strength_mg": 20.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "intestinal-helminths" }, { "id": 1016, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Ascariasis - StatPearls disease-level clinical article, filed as intestinal-helminths-clinical.txt", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Complete intestinal obstruction, volvulus, ischemia, or perforation requires urgent surgical or endoscopic intervention." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "intestinal-helminths" }, { "id": 1015, "generic": "Ivermectin", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 6.0, "adult_dose": "200 mcg/kg single dose", "adult_duration": "single-dose", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (ivermectin monograph)", "rationale": "Binds glutamate-gated chloride channels in the parasite's nerve and muscle cells, causing paralysis and death. Used as the alternative agent when Strongyloides or Ascaris is suspected, as noted in the cautions, rather than as routine first-line therapy.", "cautions": [ "The Egyptian National Drug Formulary - Antimicrobial 2023 ivermectin monograph does not contraindicate it by age. What it says is to avoid the drug below 2 years or 15 kg, or to use it there only with extreme caution and close monitoring, because the blood-brain barrier is less developed at that age than in an older child and the risk of CNS effects - encephalopathy - is higher. Its dosing section starts at children 15 kg and over.", "Take on an empty stomach with water.", "Ivermectin is an alternative agent for Strongyloides and Ascaris infections." ], "peds_mgkg_low": 0.2, "peds_mgkg_high": 0.2, "peds_max_mg": 15.0, "peds_basis": "dose", "peds_unit": "mg", "peds_note": "Single dose (200 mcg/kg) for children >= 15 kg; take with water on an empty stomach", "peds_min_weight_kg": 15.0, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 20, "low_mg": 4, "high_mg": 4, "capped": false }, { "weight_kg": 30, "low_mg": 6, "high_mg": 6, "capped": false }, { "weight_kg": 40, "low_mg": 8, "high_mg": 8, "capped": false } ], "brands": [ { "trade_name": "IVACTIN 6MG 6 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DELTA PHARMA", "price_egp": 13.5, "pack_count": 6, "unit_price": 2.25, "strength_mg": 6.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "IVERZINE 6MG 24 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA CO. > UNIPHARMA", "price_egp": 84.0, "pack_count": 24, "unit_price": 3.5, "strength_mg": 6.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "intestinal-helminths" } ] }