{
  "schema_version": 1,
  "kind": "condition",
  "id": "nephrotic-syndrome-referral",
  "name": "Nephrotic Syndrome (Referral & Supportive Care)",
  "category": "chronic",
  "sources": "Enalapril Maleate 10mg tablets SmPC section 4.2 Posology and method of administration (eMC product 561) · Furosemide 40mg Tablets SmPC (https://www.medicines.org.uk/emc/product/2465/smpc) · KDIGO Clinical Practice Guideline for Glomerular Diseases 2021",
  "review_status": "reviewed",
  "verified_against": "Enalapril Maleate 10mg tablets SmPC section 4.2 Posology and method of administration (eMC product 561) · Furosemide 40mg Tablets SmPC (https://www.medicines.org.uk/emc/product/2465/smpc)",
  "verified_date": "2026-08",
  "treatments": [
    {
      "id": 1214,
      "generic": "Furosemide",
      "line": 1,
      "is_adjunct": false,
      "form": "oral.solid",
      "strength_mg": 40.0,
      "adult_dose": "The usual initial dose of furosemide is 20 mg to 40 mg given as a single-dose, injected intramuscularly or intravenously.",
      "adult_duration": null,
      "dose_source": "Furosemide 40mg Tablets SmPC (https://www.medicines.org.uk/emc/product/2465/smpc)",
      "rationale": "Loop diuretic controlling the edema caused by heavy proteinuria and hypoalbuminemia while nephrology referral for biopsy and immunosuppressive therapy is arranged.",
      "cautions": [
        "Requires urgent nephrology referral for diagnostic renal biopsy and immunosuppressive therapy.",
        "Monitor for intravascular volume depletion, hypokalemia, and hypercoagulability (DVT risk).",
        "Dietary sodium restriction (<2 g/day) is essential.",
        "Furosemide Injection is contraindicated in patients with anuria."
      ],
      "peds_mgkg_low": 1.0,
      "peds_mgkg_high": 2.0,
      "peds_max_mg": 40.0,
      "peds_basis": "dose",
      "peds_unit": "mg",
      "peds_note": "The usual initial dose of Furosemide Injection (intravenously or intramuscularly) in pediatric patients is 1 mg/kg body weight administered slowly (over 1 minute to 2 minutes).",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": [
        {
          "weight_kg": 10,
          "low_mg": 10,
          "high_mg": 20,
          "capped": false
        },
        {
          "weight_kg": 20,
          "low_mg": 20,
          "high_mg": 40,
          "capped": false
        },
        {
          "weight_kg": 30,
          "low_mg": 30,
          "high_mg": 40,
          "capped": true
        },
        {
          "weight_kg": 40,
          "low_mg": 40,
          "high_mg": 40,
          "capped": true
        }
      ],
      "brands": [
        {
          "trade_name": "ODEMENT 40MG 10 TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "EL NASR",
          "price_egp": 1.3,
          "pack_count": 10,
          "unit_price": 0.13,
          "strength_mg": 40.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "FRUZEX 40MG 12 TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "MISR",
          "price_egp": 3.25,
          "pack_count": 12,
          "unit_price": 0.27,
          "strength_mg": 40.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "FUROSEMIDE 40MG 20 TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "SEDICO",
          "price_egp": 7.5,
          "pack_count": 20,
          "unit_price": 0.38,
          "strength_mg": 40.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "FURORETIC 40 MG 30 TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "DEBEIKY > VETOPHARM",
          "price_egp": 14.25,
          "pack_count": 30,
          "unit_price": 0.47,
          "strength_mg": 40.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "LAFUREX 40MG 20 TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "AMOUN",
          "price_egp": 9.5,
          "pack_count": 20,
          "unit_price": 0.47,
          "strength_mg": 40.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "SALEX 40 MG 20 TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "ARAB DRUG COMPANY (ADCO)",
          "price_egp": 10.0,
          "pack_count": 20,
          "unit_price": 0.5,
          "strength_mg": 40.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "FUROSEMIDE-ALEX 40MG 20 TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "ALEXANDRIA",
          "price_egp": 19.0,
          "pack_count": 20,
          "unit_price": 0.95,
          "strength_mg": 40.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "LASIX 40 MG 24 TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "SANOFI",
          "price_egp": 30.0,
          "pack_count": 24,
          "unit_price": 1.25,
          "strength_mg": 40.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "GENESEMIDE 20MG/5ML SYRUP 120 ML",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "MEDIZEN PHARMACEUTICAL INDUSTRIES > VODACHEM",
          "price_egp": 56.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 20.0,
          "exact_strength": false,
          "exact_form": false,
          "discontinued": false,
          "also_contains": null
        }
      ],
      "condition_id": "nephrotic-syndrome-referral"
    }
  ]
}