{ "schema_version": 1, "kind": "condition", "id": "peripheral-arterial-disease", "name": "Peripheral Arterial Disease", "category": "chronic", "sources": "Cilostazol 100 mg tablets SmPC sections 4.2-4.4 (eMC product 2609) · ESC Guidelines on Diagnosis and Treatment of Peripheral Arterial Diseases 2017 · UK eMC Atorvastatin 10 mg Film-coated Tablets SmPC section 4.2 Posology and method of administration (eMC product 13672) · eMC SmPC, Tritace 10mg Tablets (Sanofi), section 4.1 and 4.2", "review_status": "reviewed", "verified_against": "Cilostazol 100 mg tablets SmPC sections 4.2-4.4 (eMC product 2609) · ESC Guidelines on Diagnosis and Treatment of Peripheral Arterial Diseases 2017 · UK eMC Atorvastatin 10 mg Film-coated Tablets SmPC section 4.2 Posology and method of administration (eMC product 13672) · eMC SmPC, Tritace 10mg Tablets (Sanofi), section 4.1 and 4.2 · Peripheral Arterial Disease - disease-level clinical article (peripheral-arterial-disease-clinical.txt) · Egyptian National Drug Formulary - Cardiovascular", "verified_date": "2026-08", "treatments": [ { "id": 1384, "generic": "Acetylsalicylic acid", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 75.0, "adult_dose": "75-100 mg once daily", "adult_duration": "long-term", "dose_source": "ESC Guidelines on Diagnosis and Treatment of Peripheral Arterial Diseases 2017", "rationale": "Aspirin is an antiplatelet agent used in peripheral arterial disease to lower the risk of cardiovascular events such as myocardial infarction and stroke, reflecting the systemic atherosclerotic burden that PAD represents.", "cautions": [ "There is a gastrointestinal bleeding risk; co-prescribe a PPI if GI risk is high.", "Avoid in active peptic ulcer disease." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not indicated for pediatric peripheral vascular disease", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "AGGREX 75MG 60 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA", "price_egp": 33.0, "pack_count": 60, "unit_price": 0.55, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ASPOCID 75MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 22.0, "pack_count": 20, "unit_price": 1.1, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ASPOCID 75MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 33.0, "pack_count": 30, "unit_price": 1.1, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ASPIRIN-CHEMIPHARM 75 MG 30 CHEW.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CHEMIPHARM", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RIVO 75 MG 30 CHEW. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 21.0, "pack_count": null, "unit_price": null, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ASPOCID PAEDIATRIC 75MG 30 CHEW. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 35.0, "pack_count": null, "unit_price": null, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EZACARD 75 MG 30 E.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MULTI-APEX", "price_egp": 51.0, "pack_count": null, "unit_price": null, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "peripheral-arterial-disease" }, { "id": 1386, "generic": "Atorvastatin", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 40.0, "adult_dose": "40-80 mg once daily (or high-intensity statin therapy to achieve target LDL cholesterol reduction)", "adult_duration": "long-term", "dose_source": "UK eMC Atorvastatin 10 mg Film-coated Tablets SmPC section 4.2 Posology and method of administration (eMC product 13672)", "rationale": "Atorvastatin is a statin that lowers LDL cholesterol and helps stabilize atherosclerotic plaque; high-intensity statin therapy is recommended for patients with peripheral arterial disease to reduce cardiovascular risk.", "cautions": [ "Monitor hepatic transaminases and muscle symptoms.", "Contraindicated in active liver disease and pregnancy." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist lipid clinic management required for pediatric familial hypercholesterolemia", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "ECATROVA 40 MG 21 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBAL NAPI PHARMACEUTICALS > M.N.-EGYPT", "price_egp": 66.0, "pack_count": 21, "unit_price": 3.14, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SIGMALIP 40MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 32.4, "pack_count": 10, "unit_price": 3.24, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LIPICOLE 40MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 35.0, "pack_count": 10, "unit_price": 3.5, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ORGOVASTIN 40MG 14 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANOPHARMA > ORGANO", "price_egp": 55.0, "pack_count": 14, "unit_price": 3.93, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TORVAST 40MG 7 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGYPHAR", "price_egp": 38.0, "pack_count": 7, "unit_price": 5.43, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ATOR 40 MG 10 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 106.0, "pack_count": 10, "unit_price": 10.6, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LIPITOR 40 MG 7 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PFIZER > VIATRIS EGYPT", "price_egp": 113.0, "pack_count": 7, "unit_price": 16.14, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ATORSTAT 40MG 14 BISCORED TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DELTA PHARMA", "price_egp": 76.0, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "peripheral-arterial-disease" }, { "id": 1388, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Peripheral Arterial Disease - disease-level clinical article (peripheral-arterial-disease-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Chronic limb-threatening ischemia (rest pain or tissue loss/nonhealing wounds) is the most severe form of PAD and carries a high risk of limb loss and death.", "RED FLAG - Refer for revascularisation (endovascular or surgical) when claudication is lifestyle-limiting and refractory to medical therapy, or when chronic limb-threatening ischaemia is present.", "RED FLAG - Acute limb ischemia (from in-situ thrombosis or embolism) as an emergency presentation in patients with underlying PAD is not flagged" ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "peripheral-arterial-disease" }, { "id": 1389, "generic": "Clopidogrel", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 75.0, "adult_dose": "75 mg once daily", "adult_duration": null, "dose_source": "Egyptian National Drug Formulary - Cardiovascular", "rationale": "First-line antiplatelet agent recommended as an alternative to aspirin to lower the risk of myocardial infarction, stroke, and vascular death in peripheral arterial disease.", "cautions": [ "Active pathological bleeding (eg, peptic ulcer, intracranial hemorrhage). " ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "No paediatric dose is stated in the sources held for this drug.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "BLOTAGRIL 75MG 30 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEDIZEN PHARMACEUTICAL INDUSTRIES", "price_egp": 33.0, "pack_count": 30, "unit_price": 1.1, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ITOLAVIX 75 MG 30 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA > INTERNATIONAL TRADING OFFICE", "price_egp": 54.0, "pack_count": 30, "unit_price": 1.8, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BORGAVIX 75MG 30 F.C. TABLETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "BORG", "price_egp": 66.0, "pack_count": 30, "unit_price": 2.2, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SIGAGREL 75MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA", "price_egp": 30.0, "pack_count": 10, "unit_price": 3.0, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLOPACIRC 75 MG 30 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "COPAD PHARMA", "price_egp": 117.0, "pack_count": 30, "unit_price": 3.9, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "THROMBO 75MG 30 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 123.0, "pack_count": 30, "unit_price": 4.1, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PLATENOR 75MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HI-PHARM > EGYPHARMA-EGYPT", "price_egp": 150.0, "pack_count": 30, "unit_price": 5.0, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PLAVIX 75 MG 28 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI WINTHROP > SANOFI", "price_egp": 311.0, "pack_count": 28, "unit_price": 11.11, "strength_mg": 75.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "peripheral-arterial-disease" }, { "id": 1385, "generic": "Cilostazol", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 100.0, "adult_dose": "100 mg twice daily taken 30 minutes before breakfast and dinner", "adult_duration": "3 months initial trial; discontinue if no improvement in walking distance, otherwise long-term under periodic review", "dose_source": "Cilostazol 100 mg tablets SmPC sections 4.2-4.4 (eMC product 2609)", "rationale": "Phosphodiesterase-3 inhibitor indicated solely for symptomatic improvement of walking distance in lifestyle-limiting claudication; does not replace mandatory antiplatelet and high-intensity statin secondary prevention.", "cautions": [ "CONTRAINDICATED in congestive heart failure of any severity.", "Common side effects include headache, diarrhea, and palpitations.", "Reduce dose to 50 mg BID if co-administered with strong CYP3A4 or CYP2C19 inhibitors.", "Congestive heart failure rules it out completely, as does any history of ventricular tachycardia, ventricular fibrillation or multifocal ventricular ectopics.", "Also out: any bleeding tendency, active peptic ulcer, a haemorrhagic stroke within six months, an infarct or coronary intervention within six months, unstable angina, or two or more other antiplatelets and anticoagulants already running.", "Reassess at three months. If the walking distance has not improved, stop it rather than continue." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not indicated in children", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "CILOMEPATAL 100MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEPACO", "price_egp": 30.0, "pack_count": 20, "unit_price": 1.5, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "INFARCA 100 MG 30 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DEBEIKY > ZAD", "price_egp": 54.0, "pack_count": 30, "unit_price": 1.8, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "STAZOLA 100MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CHEMIPHARM", "price_egp": 36.0, "pack_count": 20, "unit_price": 1.8, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SERCPROVE 100 MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA CO. > UNIPHARMA", "price_egp": 48.0, "pack_count": 20, "unit_price": 2.4, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLAUDOL 100 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DELTA PHARMA > ACTIVA THERAPEUTICS", "price_egp": 90.0, "pack_count": 30, "unit_price": 3.0, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CILOSORT 100 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MULTICARE > PHARMACARE", "price_egp": 93.0, "pack_count": 30, "unit_price": 3.1, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PLETAAL 100 MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "OTSUKA", "price_egp": 160.0, "pack_count": 20, "unit_price": 8.0, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CILOBIOGEN 100MG 10 SCORED TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "INTERNATIONAL DRUG AGENCY (IDI) > BIOCAPITAL PHARMA", "price_egp": 13.2, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "peripheral-arterial-disease" }, { "id": 1387, "generic": "Ramipril", "line": 2, "is_adjunct": true, "form": "oral.solid", "strength_mg": 10.0, "adult_dose": "2.5 mg once daily initially, titrated over 3-4 weeks to a target maintenance dose of 10 mg once daily", "adult_duration": "Long-term", "dose_source": "eMC SmPC, Tritace 10mg Tablets (Sanofi), section 4.1 and 4.2", "rationale": "29 live products. The SmPC carries an explicit cardiovascular-prevention indication - 'reduction of cardiovascular morbidity and mortality in patients with manifest atherothrombotic cardiovascular disease (history of coronary heart disease or stroke, or peripheral vascular disease)'. Every patient in this condition qualifies, and it is the one vascular-protection component the row is missing.", "cautions": [ "This reduces future cardiovascular events; it does not improve claudication distance - the cilostazol and exercise therapy do that.", "CONTRAINDICATED in pregnancy and in any previous angioedema on an ACE inhibitor or ARB.", "Contraindicated with sacubitril/valsartan and in bilateral renal artery stenosis - which is more likely in a patient who already has peripheral arterial disease, so check renal function carefully.", "Check creatinine and potassium 1-2 weeks after starting and after each increase; a creatinine rise of up to 30% is acceptable, more than that means stopping and investigating.", "Dry cough affects up to 1 in 10 - switch to an ARB rather than adding a cough suppressant.", "Do not combine with an ARB or aliskiren.", "Withhold during any dehydrating illness (vomiting, diarrhoea, heat) - sick-day rules." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Safety and efficacy in children have not been established and the SmPC makes no posology recommendation.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "RECARDOPRIL 10MG 10 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 19.2, "pack_count": 10, "unit_price": 1.92, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RAMPITENSIVE 10MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMOUN", "price_egp": 20.0, "pack_count": 10, "unit_price": 2.0, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RIGHT-ACE 10 MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ADWIA", "price_egp": 66.0, "pack_count": 30, "unit_price": 2.2, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RAMIPRIL 10 MG 7 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 17.4, "pack_count": 7, "unit_price": 2.49, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RAMPECARDIN 10 MG 7 TABS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 24.0, "pack_count": 7, "unit_price": 3.43, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TRITACE PROTECT 10 MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 132.0, "pack_count": 20, "unit_price": 6.6, "strength_mg": 10.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "peripheral-arterial-disease" } ] }