Dawaa Reference

chronic

Peyronie's Disease (Evaluation & Referral)

Treatment options, dosing, cautions and Egyptian brands from the shipped Dawaa Reference card.

Evidence status

Checked against the sources named below

Sources5 sources

Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560) · DailyMed Ibuprofen 400mg Tablet Package Insert, SetID 8774da38-a289-49ef-92e1-4c129ae3eeed · DailyMed Pentoxifylline 400mg Extended-Release Tablet Package Insert · EAU Guidelines on Penile Curvature 2023 · Peyronie Disease - disease-level clinical article (peyronie-disease-referral-full.txt)

Verified against3 documents
  • DailyMed Ibuprofen 400mg Tablet Package Insert, SetID 8774da38-a289-49ef-92e1-4c129ae3eeed
  • DailyMed Pentoxifylline 400mg Extended-Release Tablet Package Insert
  • Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560)

Verified date2026-08

Presentation reference

Is it this?

Reference only, to read alongside your own examination.

Symptoms — what the patient reports (4)

  • Progressive deformity with painful erections marks the active phase, while a stable deformity for 3 months or more with pain resolved marks the chronic phase [visible deformity]
  • Curvature exceeding 30 degrees is roughly the point at which it starts to interfere with intercourse
  • About 4% have a hereditary predisposition, and roughly 1 in 5 also have Dupuytren contractures
  • Patients usually seek care around 6 months after onset, most often for curvature, then pain, then a palpable plaque [plaques]

Signs — what you find (4)

  • Curvature of 20 degrees or less is essentially normal, while 60 degrees or more is usually unusable for intercourse and may need surgery
  • Self-reported curvature is unreliable; most patients overestimate it and only about 1 in 5 are close to accurate
  • The plaque is usually located on the top surface of the penis, and an hourglass shape or buckling under pressure during erection may be seen [joint instability · plaques]
  • Larger calcified plaques over 1.5 cm predict a higher chance of eventually needing surgery [plaques]

Tests (4)

  • No lab testing or imaging is mandatory, and testosterone is only checked if hypogonadism is suspected
  • Major urology guidelines recommend an in-office injection test with or without Doppler ultrasound before any invasive treatment
  • Duplex ultrasound can find calcifications, assess blood flow, and detect plaques that are hard to feel by hand
  • MRI is not currently recommended for routine use because of its high cost and limited availability

If not this — what else fits (4)

  • A lifelong, gentle ventral curve with no plaque points to a congenital cause rather than acquired dorsal Peyronie disease
  • Ventral curvature accompanying hypospadias suggests chordee rather than acquired Peyronie disease
  • A sudden pop, immediate severe pain, and loss of erection during intercourse point to a penile fracture, not Peyronie disease
  • Pain without any deformity, possibly referred from the bladder, prostate, or back, points to penile pain syndrome instead

SourceStatPearls "Peyronie Disease" - disease-level clinical article

Presentation findings are traced to the source above.

1

IBUPROFEN

1st line

Strength400 mg

Formoral.solid

Adult dose and duration

200 to 400 mg up to three times a day as required, with or after food. Leave at least four hours between doses and never exceed 1200 mg in any 24 hours.

Paediatric dose

Adult-only condition - paediatric section not applicable

Dose source

Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560)

Why

Ibuprofen is an NSAID used to relieve penile pain during the active inflammatory phase of Peyronie's disease; it controls symptoms only and does not reverse the fibrous plaque, which needs urology assessment.

Cautions
  • Oral NSAIDs aim to relieve pain in the active inflammatory phase; they do not reverse established fibrous plaque curvature.
  • Urgent urology referral is required for assessment of intralesional injections or surgical reconstruction.
  • Take with food to minimize gastric distress.
Egyptian brands
Egyptian brandManufacturerIndicative price
DAJUANOFEN 400 MG 20 F.C. TABS.COPAD PHARMA5.00 EGP (0.25/unit)
FLABU 400MG 10 F.C.TAB.DELTA PHARMA3.75 EGP (0.38/unit)
NOVA-PROFEN 400MG 30 F.C. TABLETSSANOFI12.75 EGP (0.42/unit)
IBUPROFEN 400 MG 10 TAB.SEDICO6.00 EGP (0.60/unit)
MAFO 400 MG 30 F.C.TABSEIPICO42.00 EGP (1.40/unit)
BRUFEN 400 MG 30 TABS.KAHIRA > ABBOTT LABORATORIES78.00 EGP (2.60/unit)
PROFUSOL 400MG 20 S.G CAPS.EUROPEAN EGYPTIAN PHARM. IND.31.00 EGP
ANALGIPROF 400 MG 25 SACHETSEVA PHARMA37.50 EGP
NOVA-PROFEN 100MG/5ML ORAL SUSP. 100ML? strength differs? different route - not oral solidSANOFI2.25 EGP
BRUFEMOL-N SUSP. 60 ML? strength differs? different route - not oral solidARAB DRUG COMPANY (ADCO)4.50 EGP

Prices are indicative (dataset snapshot 2026-06); verify with the pharmacy.