{
  "schema_version": 1,
  "kind": "condition",
  "id": "peyronie-disease-referral",
  "name": "Peyronie's Disease (Evaluation & Referral)",
  "category": "chronic",
  "sources": "Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560) · DailyMed Ibuprofen 400mg Tablet Package Insert, SetID 8774da38-a289-49ef-92e1-4c129ae3eeed · DailyMed Pentoxifylline 400mg Extended-Release Tablet Package Insert · EAU Guidelines on Penile Curvature 2023 · Peyronie Disease - disease-level clinical article (peyronie-disease-referral-full.txt)",
  "review_status": "reviewed",
  "verified_against": "DailyMed Ibuprofen 400mg Tablet Package Insert, SetID 8774da38-a289-49ef-92e1-4c129ae3eeed · DailyMed Pentoxifylline 400mg Extended-Release Tablet Package Insert · Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560)",
  "verified_date": "2026-08",
  "treatments": [
    {
      "id": 1398,
      "generic": "Ibuprofen",
      "line": 1,
      "is_adjunct": false,
      "form": "oral.solid",
      "strength_mg": 400.0,
      "adult_dose": "200 to 400 mg up to three times a day as required, with or after food. Leave at least four hours between doses and never exceed 1200 mg in any 24 hours.",
      "adult_duration": null,
      "dose_source": "Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560)",
      "rationale": "Ibuprofen is an NSAID used to relieve penile pain during the active inflammatory phase of Peyronie's disease; it controls symptoms only and does not reverse the fibrous plaque, which needs urology assessment.",
      "cautions": [
        "Oral NSAIDs aim to relieve pain in the active inflammatory phase; they do not reverse established fibrous plaque curvature.",
        "Urgent urology referral is required for assessment of intralesional injections or surgical reconstruction.",
        "Take with food to minimize gastric distress."
      ],
      "peds_mgkg_low": null,
      "peds_mgkg_high": null,
      "peds_max_mg": null,
      "peds_basis": null,
      "peds_unit": null,
      "peds_note": "Adult-only condition - paediatric section not applicable",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": null,
      "brands": [
        {
          "trade_name": "DAJUANOFEN 400 MG 20 F.C. TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "COPAD PHARMA",
          "price_egp": 5.0,
          "pack_count": 20,
          "unit_price": 0.25,
          "strength_mg": 400.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "FLABU 400MG 10 F.C.TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "DELTA PHARMA",
          "price_egp": 3.75,
          "pack_count": 10,
          "unit_price": 0.38,
          "strength_mg": 400.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "NOVA-PROFEN 400MG 30 F.C. TABLETS",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "SANOFI",
          "price_egp": 12.75,
          "pack_count": 30,
          "unit_price": 0.42,
          "strength_mg": 400.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "IBUPROFEN 400 MG 10 TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "SEDICO",
          "price_egp": 6.0,
          "pack_count": 10,
          "unit_price": 0.6,
          "strength_mg": 400.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "MAFO 400 MG  30 F.C.TABS",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "EIPICO",
          "price_egp": 42.0,
          "pack_count": 30,
          "unit_price": 1.4,
          "strength_mg": 400.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "BRUFEN 400 MG 30 TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "KAHIRA > ABBOTT LABORATORIES",
          "price_egp": 78.0,
          "pack_count": 30,
          "unit_price": 2.6,
          "strength_mg": 400.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "PROFUSOL 400MG 20 S.G CAPS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "EUROPEAN EGYPTIAN PHARM. IND.",
          "price_egp": 31.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 400.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "ANALGIPROF 400 MG 25 SACHETS",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "EVA PHARMA",
          "price_egp": 37.5,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 400.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "NOVA-PROFEN  100MG/5ML ORAL SUSP. 100ML",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "SANOFI",
          "price_egp": 2.25,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 100.0,
          "exact_strength": false,
          "exact_form": false,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "BRUFEMOL-N SUSP. 60 ML",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "ARAB DRUG COMPANY (ADCO)",
          "price_egp": 4.5,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": null,
          "exact_strength": false,
          "exact_form": false,
          "discontinued": false,
          "also_contains": null
        }
      ],
      "condition_id": "peyronie-disease-referral"
    }
  ]
}