{
  "schema_version": 1,
  "kind": "condition",
  "id": "polycystic-kidney-disease",
  "name": "Polycystic kidney disease",
  "category": "chronic",
  "sources": "Autosomal Dominant Polycystic Kidney Disease - StatPearls - NCBI Bookshelf - https://www.ncbi.nlm.nih.gov/books/NBK532934/ · ICPC-3 (WONCA International Classification of Primary Care, 3rd edition) class UD55.00 - condition scope only, no dose · No dose - referral pathway, no medicine given in primary care",
  "review_status": "reviewed",
  "verified_against": "No dose - referral pathway, no medicine given in primary care · Polycystic kidney disease - disease-level clinical article (polycystic-kidney-disease-clinical.txt)",
  "verified_date": "2026-08",
  "treatments": [
    {
      "id": 1425,
      "generic": "No drug therapy in primary care (Referral & Advice)",
      "line": 1,
      "is_adjunct": false,
      "form": null,
      "strength_mg": null,
      "adult_dose": "An inherited disorder causing progressive kidney cysts and eventual kidney failure; the GP recognises the diagnosis, often via family history or imaging, and refers to nephrology for monitoring.",
      "adult_duration": "Refer, with advice",
      "dose_source": "No dose - referral pathway, no medicine given in primary care",
      "rationale": "An inherited disorder causing progressive kidney cysts and eventual kidney failure; the GP recognises the diagnosis, often via family history or imaging, and refers to nephrology for monitoring.",
      "cautions": [
        "RED FLAG - Infected renal cyst or acute pyelonephritis requiring urgent admission and targeted parenteral antibiotics: assess urgently and refer.",
        "RED FLAG - Ruptured intracranial berry aneurysm presenting as sudden thunderclap headache: assess urgently and refer.",
        "High blood pressure, blood in the urine, or declining kidney function in a known polycystic kidney disease patient needs prompt nephrology involvement.",
        "No medicine is prescribed for this in primary care - this entry is for recognition and referral. Anything given is decided by the service it is referred to.",
        "RED FLAG - Cerebral aneurysm is the most serious extrarenal complication of ADPKD (4x higher prevalence than general population).",
        "RED FLAG - Severe cyst hemorrhage causing hemodynamic instability requires emergency hospitalization and transfusion."
      ],
      "peds_mgkg_low": null,
      "peds_mgkg_high": null,
      "peds_max_mg": null,
      "peds_basis": null,
      "peds_unit": null,
      "peds_note": "Children follow the same pathway: recognise and refer. No primary-care medicine is implied.",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": null,
      "brands": [],
      "condition_id": "polycystic-kidney-disease"
    }
  ]
}