{
  "schema_version": 1,
  "kind": "condition",
  "id": "polycythemia-referral",
  "name": "Polycythaemia (Erythrocytosis Investigation & Referral)",
  "category": "chronic",
  "sources": "BSH Guideline for the Diagnosis and Management of Polycythemia Vera 2019",
  "review_status": "reviewed",
  "verified_against": "BSH Guideline for the Diagnosis and Management of Polycythemia Vera 2019 · Polycythaemia (Erythrocytosis Investigation & Referral) - disease-level clinical article (polycythemia-referral-clinical.txt)",
  "verified_date": "2026-08",
  "treatments": [
    {
      "id": 1428,
      "generic": "Acetylsalicylic acid",
      "line": 1,
      "is_adjunct": false,
      "form": "oral.solid",
      "strength_mg": 75.0,
      "adult_dose": "75-100 mg once daily with food",
      "adult_duration": "long-term under haematologist monitoring",
      "dose_source": "BSH Guideline for the Diagnosis and Management of Polycythemia Vera 2019",
      "rationale": "Low-dose aspirin reduces arterial and venous thrombotic events in polycythemia vera",
      "cautions": [
        "SPECIALIST HAEMATOLOGY REFERRAL IS MANDATORY for hematocrit >0.52 in men or >0.48 in women.",
        "Primary treatment for polycythemia vera is therapeutic venesection (target hematocrit <0.45) under haematology guidance.",
        "Differentiate primary polycythemia vera (JAK2 mutation) from secondary erythrocytosis (chronic hypoxia, smoking, OSA, renal tumors).",
        "Take aspirin with food to reduce GI bleeding risk."
      ],
      "peds_mgkg_low": null,
      "peds_mgkg_high": null,
      "peds_max_mg": null,
      "peds_basis": null,
      "peds_unit": null,
      "peds_note": "CONTRAINDICATED in children under 16 years due to Reye's syndrome risk",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": null,
      "brands": [
        {
          "trade_name": "AGGREX 75MG 60 TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "RAMEDA",
          "price_egp": 33.0,
          "pack_count": 60,
          "unit_price": 0.55,
          "strength_mg": 75.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "ASPOCID 75MG 20 TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "CID",
          "price_egp": 22.0,
          "pack_count": 20,
          "unit_price": 1.1,
          "strength_mg": 75.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "ASPOCID 75MG 30 TAB.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "CID",
          "price_egp": 33.0,
          "pack_count": 30,
          "unit_price": 1.1,
          "strength_mg": 75.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "ASPIRIN-CHEMIPHARM 75 MG 30 CHEW.TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "CHEMIPHARM",
          "price_egp": 12.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 75.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "RIVO 75 MG 30 CHEW. TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "ARAB DRUG COMPANY (ADCO)",
          "price_egp": 21.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 75.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "ASPOCID PAEDIATRIC 75MG 30 CHEW. TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "CID",
          "price_egp": 35.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 75.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "EZACARD 75 MG 30 E.C. TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "MULTI-APEX",
          "price_egp": 51.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": 75.0,
          "exact_strength": true,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        }
      ],
      "condition_id": "polycythemia-referral"
    },
    {
      "id": 1429,
      "generic": "Referral & safety-netting (no drug therapy)",
      "line": 1,
      "is_adjunct": false,
      "form": null,
      "strength_mg": null,
      "adult_dose": null,
      "adult_duration": null,
      "dose_source": "Polycythaemia (Erythrocytosis Investigation & Referral) - disease-level clinical article (polycythemia-referral-clinical.txt)",
      "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.",
      "cautions": [
        "RED FLAG - Aspirin is contraindicated in patients with extreme thrombocytosis (platelets >1 million/microliter) due to acquired von Willebrand disease."
      ],
      "peds_mgkg_low": null,
      "peds_mgkg_high": null,
      "peds_max_mg": null,
      "peds_basis": null,
      "peds_unit": null,
      "peds_note": null,
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": null,
      "brands": [],
      "condition_id": "polycythemia-referral"
    }
  ]
}