{ "schema_version": 1, "kind": "condition", "id": "pompholyx", "name": "Pompholyx (Dyshidrotic Eczema)", "category": "chronic", "sources": "Primary Care Dermatology Society (PCDS): Eczema - Hand Dermatitis 2025 · Egyptian National Drug Formulary - Endocrine System 2024 (betamethasone monograph) · Dermovate (clobetasol propionate 0.05%) Cream SmPC section 4.2 (eMC product 939)", "review_status": "reviewed", "verified_against": "Egyptian National Drug Formulary - Endocrine System 2024 (betamethasone monograph) · Dermovate (clobetasol propionate 0.05%) Cream SmPC section 4.2 (eMC product 939) · Primary Care Dermatology Society (PCDS): Eczema - Hand Dermatitis 2025", "verified_date": "2026-08", "treatments": [ { "id": 1437, "generic": "Betamethasone", "line": 1, "is_adjunct": false, "form": "topical", "strength_mg": null, "adult_dose": "Apply 0.1% cream/ointment thinly twice daily to vesicles on the palms and soles", "adult_duration": "2-4 weeks for the acute flare, then reduce to twice-weekly maintenance on previously affected skin", "dose_source": "Egyptian National Drug Formulary - Endocrine System 2024 (betamethasone monograph)", "rationale": "The atopic-eczema-adult entry stops at mild (hydrocortisone) and moderate (clobetasone) potency, which is right for the face, flexures, trunk and limbs it covers. Pompholyx affects palms and soles, where the stratum corneum is far thicker, so treatment starts here at potent rather than stepping up to it.", "cautions": [ "Do not use on the face, groin, or flexures - reserve potent steroid for the thick skin of palms and soles.", "Step up to a very potent steroid (clobetasol propionate) if there is no improvement after 2 weeks.", "Watch for secondary bacterial or fungal infection in macerated, weeping skin.", "The Egyptian formulary limits a course to 5 days when this is used on the face or in a child - 0.1% betamethasone is potent and the face thins fastest." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Pompholyx is uncommon before adolescence; use a lower-potency steroid and seek paediatric dermatology advice if it occurs in a young child", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "CRONOMESONE 0.1% CREAM 15 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 4.0, "pack_count": null, "unit_price": null, "strength_mg": 15000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CRONOMESONE 0.1% OINT. 15 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 4.0, "pack_count": null, "unit_price": null, "strength_mg": 15000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BETNOVATE 0.1% TOP. OINT. 15 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SMITHKLINE BEECHAM > GLAXO SMITHKLINE", "price_egp": 6.9, "pack_count": null, "unit_price": null, "strength_mg": 15000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BETADERM 0.1% CREAM 15 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 18.0, "pack_count": null, "unit_price": null, "strength_mg": 15000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BETAVAL 0.1% CREAM 20 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 20.0, "pack_count": null, "unit_price": null, "strength_mg": 20000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BETADERM 0.1% CREAM 30 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 23.0, "pack_count": null, "unit_price": null, "strength_mg": 30000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BETAMETHASONE DIPROPIONATE 0.05% CREAM 20 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 11.5, "pack_count": null, "unit_price": null, "strength_mg": 20000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BETAMETHASONE DIPROPIONATE 0.05% OINT. 20 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 11.5, "pack_count": null, "unit_price": null, "strength_mg": 20000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "pompholyx" }, { "id": 1438, "generic": "Clobetasol propionate", "line": 2, "is_adjunct": false, "form": "topical", "strength_mg": null, "adult_dose": "Apply 0.05% cream/ointment thinly twice daily to vesicles on the palms and soles; night-time occlusion with cotton gloves can be added once the skin is no longer weeping", "adult_duration": "2-4 weeks for the acute flare, then reduce to twice-weekly maintenance on previously affected skin", "dose_source": "Dermovate (clobetasol propionate 0.05%) Cream SmPC section 4.2 (eMC product 939)", "rationale": "For severe or potent-steroid-refractory vesicular flares on the palms and soles. This is the same very-potent option used for lichen planus, at the same strength and frequency.", "cautions": [ "Clobetasol propionate is a superpotent topical corticosteroid - do not use continuously for more than 4 weeks without medical review.", "Avoid the face, axillae, and groin.", "More than 50 g per week risks systemic absorption (adrenal suppression, Cushingoid effect).", "Ceilings the label sets: no more than 50 g in a week, no longer than 4 weeks, courses kept to about five days where possible and reviewed weekly. If it is still needed after that, step down to a weaker steroid and keep an emollient going. Clobetasol is the most potent class - atrophy and adrenal suppression are the price of open-ended use." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist dermatology supervision required before using a very potent steroid in a child", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "CLOBITAT 0.05% TOPICAL CREAM 15 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "BIORIGINAL INTERNATIONAL GROUP PHARMA EGYPT", "price_egp": 5.5, "pack_count": null, "unit_price": null, "strength_mg": 15000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DERMASOL 0.05% CREAM 20 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UP PHARMA", "price_egp": 5.5, "pack_count": null, "unit_price": null, "strength_mg": 20000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DERMASOL 0.05% OINT. 20 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UP PHARMA", "price_egp": 5.5, "pack_count": null, "unit_price": null, "strength_mg": 20000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLEROVATE 0.05% TOPICAL OINT. 25 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MARCYRL PHARMACEUTICAL INDUSTRIES (MPI)", "price_egp": 7.5, "pack_count": null, "unit_price": null, "strength_mg": 25000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLOVACORT 0.05% OINT. 20 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EUROPEAN EGYPTIAN PHARM. IND.", "price_egp": 9.0, "pack_count": null, "unit_price": null, "strength_mg": 20000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DERMOPHARM 0.05% CREAM 25 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "WESTERN PHARMACEUTICALS INDUSTRIES", "price_egp": 22.0, "pack_count": null, "unit_price": null, "strength_mg": 25000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DERMOVATE 0.05% TOP. CREAM 25 GM", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE", "price_egp": 44.0, "pack_count": null, "unit_price": null, "strength_mg": 25000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HEROBETASOL 120 MLSHAMPOO", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > HEROPHARM", "price_egp": 37.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "pompholyx" }, { "id": 1439, "generic": "Prednisolone", "line": 3, "is_adjunct": false, "form": "oral.solid", "strength_mg": 5.0, "adult_dose": "0.5 mg/kg once daily for 1 week, then reduce by 5 mg each subsequent week until stopped, continuing the topical steroid throughout", "adult_duration": "Short tapering course, typically 3-5 weeks total", "dose_source": "Primary Care Dermatology Society (PCDS): Eczema - Hand Dermatitis 2025", "rationale": "Short oral corticosteroid course for severe, extensive, or disabling flares not controlled by a very potent topical steroid", "cautions": [ "Reserve for severe, extensive, or disabling flares not controlled by a very potent topical steroid.", "Do not stop abruptly if given for more than 2-3 weeks - taper as prescribed.", "Short-term side effects include mood change, insomnia, raised blood glucose, and hypertension - check glucose if the patient is diabetic or at risk." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Refer to paediatric dermatology for severe childhood pompholyx rather than starting an oral steroid course in primary care", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "HOSTACORTIN H 5MG 30 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 12.0, "pack_count": 30, "unit_price": 0.4, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PREDNISOLONE 5 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 24.0, "pack_count": 20, "unit_price": 1.2, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PREDILONE 5MG 10 TAB. (25 STRIPS PACK)", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 250.0, "pack_count": 10, "unit_price": 25.0, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "EPICOPRED 5 MG 30 ORODISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 69.0, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PREDNISOLONE-EVA 5 MG 30 ORODISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EVA PHARMA", "price_egp": 79.5, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DISPRELONE-OD 5 MG 30 ORODISPERSABLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ANDALOUS PHARMA", "price_egp": 84.0, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SOLUPRED ORO 5 MG 30 ORODISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI WINTHROP > SANOFI", "price_egp": 84.0, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ACETASEE 1% EYE DROPS (SUSP.) 5 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA", "price_egp": 7.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "PREDNIS 5MG/5ML SYRUP 100 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 9.5, "pack_count": null, "unit_price": null, "strength_mg": 5.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "pompholyx" } ] }