{ "schema_version": 1, "kind": "condition", "id": "shigellosis", "name": "Shigellosis (Bacterial Dysentery)", "category": "acute", "sources": "Egyptian National Drug Formulary - Antimicrobial 2023, Azithromycin monograph, PDF page index 267-268 (printed p258-259), \"General dosing, susceptible infection\". Note: this monograph lists no shigellosis or campylobacter indication - the dose shown is the formulary's general azithromycin course, not an indication-matched regimen. If the project requires indication-matched sourcing, this row needs a WHO or CDC diarrhoeal-disease citation instead. · Egyptian National Drug Formulary - Antimicrobial 2023, Ciprofloxacin monograph, PDF page index 373-374 (printed p364-365). The formulary lists \"infectious diarrhea\" as an adult indication but attaches no dose to it; the 500 mg every 12 hours figure is taken from its nontyphoidal Salmonella GI regimen. There is no shigellosis, campylobacter or Yersinia enterocolitica regimen in this monograph. · WHO. The treatment of diarrhoea: a manual for physicians and other senior health workers, 4th rev. Geneva: WHO; 2005 (IRIS 10665/43209), section 4.3.1 and Table 2 · MSF Essential Drugs 2024 (ceftriaxone injectable monograph: \"Severe bacterial infections: septicaemia, meningitis, pneumonia, typhoid fever, shigellosis...\"), with the paediatric shigella course from WHO. The treatment of diarrhoea: a manual for physicians and other senior health workers, 4th rev. Geneva: WHO; 2005, antimicrobial table, Shigella dysentery · MSF Essential Drugs 2024 (zinc sulfate oral monograph: \"Adjunct to oral rehydration therapy in the event of acute and/or persistent diarrhoea in children under 5 years\"), corroborated by WHO. The treatment of diarrhoea: a manual for physicians and other senior health workers, 4th rev. Geneva: WHO; 2005 · Shigellosis - disease-level clinical article (shigellosis-full.txt)", "review_status": "reviewed", "verified_against": "Egyptian National Drug Formulary - Antimicrobial 2023, Azithromycin monograph, PDF page index 267-268 (printed p258-259), \"General dosing, susceptible infection\". Note: this monograph lists no shigellosis or campylobacter indication - the dose shown is the formulary's general azithromycin course, not an indication-matched regimen. · Egyptian National Drug Formulary - Antimicrobial 2023, Ciprofloxacin monograph, PDF page index 373-374 (printed p364-365). The formulary lists \"infectious diarrhea\" as an adult indication but attaches no dose to it; the 500 mg every 12 hours figure is taken from its nontyphoidal Salmonella GI regimen. There is no shigellosis, campylobacter or Yersinia enterocolitica regimen in this monograph. · WHO. The treatment of diarrhoea: a manual for physicians and other senior health workers, 4th rev. Geneva: WHO; 2005 (IRIS 10665/43209), section 4.3.1 and Table 2 · Shigellosis - disease-level clinical article (shigellosis-full.txt) · Shigellosis (Bacterial Dysentery) - disease-level clinical article (shigellosis-clinical.txt) · MSF Essential Drugs 2024 (ceftriaxone injectable monograph: \"Severe bacterial infections: septicaemia, meningitis, pneumonia, typhoid fever, shigellosis...\"), with the paediatric shigella course from WHO. The treatment of diarrhoea: a manual for physicians and other senior health workers, 4th rev. Geneva: WHO; 2005, antimicrobial table, Shigella dysentery · MSF Essential Drugs 2024 (zinc sulfate oral monograph: \"Adjunct to oral rehydration therapy in the event of acute and/or persistent diarrhoea in children under 5 years\"), corroborated by WHO. The treatment of diarrhoea: a manual for physicians and other senior health workers, 4th rev. Geneva: WHO; 2005", "verified_date": "2026-08", "treatments": [ { "id": 1623, "generic": "ORS", "line": 1, "is_adjunct": false, "form": "oral.solution", "strength_mg": null, "adult_dose": "Plan A (no dehydration): Drink as much ORS solution / fluid as desired after each loose stool. Plan B (some dehydration): 2,200 to 4,000 mL of ORS solution over the first 4 hours (up to 750 mL/hour), then reassess.", "adult_duration": "Until diarrhoea stops", "dose_source": "WHO. The treatment of diarrhoea: a manual for physicians and other senior health workers, 4th rev. Geneva: WHO; 2005 (IRIS 10665/43209), section 4.3.1 and Table 2", "rationale": "Core supportive treatment for bacillary dysentery; fluid and electrolyte replacement is needed whether or not antibiotics are given.", "cautions": [ "Give to all patients regardless of antibiotic use.", "Watch for dehydration, especially in young children and the elderly.", "Use the higher-volume cholera regimen only if profuse watery stool suggests cholera rather than dysentery.", "RED FLAG - High fever, bloody or mucoid stool, signs of dehydration, seizures in a child, or a suspected outbreak or cluster of cases." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Plan B (some dehydration): give the child's weight in kg x 75 mL of ORS solution in the first 4 hours, then reassess. Plan A (no dehydration): 50-100 mL after each loose stool under 2 years, 100-200 mL from 2 to 10 years.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "Under 2 years", "age_min_months": 0, "age_max_months": 23, "dose_text": "50 to 100 mL of ORS after each loose stool (Plan A, no dehydration). With some dehydration, Plan B is by weight at any age." }, { "label": "2 to 10 years", "age_min_months": 24, "age_max_months": 131, "dose_text": "100 to 200 mL of ORS after each loose stool (Plan A, no dehydration). With some dehydration, Plan B is by weight at any age." } ], "peds_doses": null, "brands": [ { "trade_name": "GLUCOHYDRAN 10 SACHET.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 1.75, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "REHYDRAN N 10 SACHET", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 4.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "REHYDRO ZINC 10 SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ORS 20 SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHAROPHARMA", "price_egp": 40.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ELECTRO MASH SYRUP 200 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 60.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLEXOLYTE ORAL REHYDRATION SOL. 240 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KEMPETRO FOR CHEMICAL INDUSTRIES", "price_egp": 65.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HERO ORS 200 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HERO > HERO MEA TRADING", "price_egp": 120.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SANSO ORS SYRUP 140 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AUG PHARMA", "price_egp": 400.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "shigellosis" }, { "id": 1625, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Shigellosis - disease-level clinical article (shigellosis-full.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - The parenteral antibiotic escalation criteria in children are sepsis, bacteremia, fever above 39C, immunosuppression, HIV, or inability to take oral medication." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "shigellosis" }, { "id": 1624, "generic": "Ciprofloxacin", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500 mg by mouth every 12 hours.", "adult_duration": "3 days", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023, Ciprofloxacin monograph, PDF page index 373-374 (printed p364-365). The formulary lists \"infectious diarrhea\" as an adult indication but attaches no dose to it; the 500 mg every 12 hours figure is taken from its nontyphoidal Salmonella GI regimen. There is no shigellosis, campylobacter or Yersinia enterocolitica regimen in this monograph.", "rationale": "A 3-day course of ciprofloxacin is the standard empiric antibiotic for shigellosis presenting as bloody dysentery.", "cautions": [ "Not routinely first-line in children (formulary note).", "The only Yersinia entry in this monograph is plague (Yersinia pestis), a different organism from the yersiniosis on this row - that condition has no formulary support here.", "The formulary reserves this enteric regimen for severe illness or patients at high risk of invasive disease.", "Classic empiric antibiotic for bacillary dysentery (bloody, mucoid stool with fever).", "Tendinitis/tendon rupture, QT prolongation, and glycaemic swings are class risks.", "Administer orally at least 2 hours before or 6 hours after antacids or other products containing calcium, iron, or zinc.", "WHO lists a second oral alternative that cannot be prescribed in Egypt - pivmecillinam, at 20 mg/kg 4 times daily for 5 days in a child, and 400 mg 4 times daily for 5 days in an adult. The Egyptian register contains no pivmecillinam product of any kind, so it is recorded here rather than offered as an option." ], "peds_mgkg_low": 10.0, "peds_mgkg_high": 10.0, "peds_max_mg": 500.0, "peds_basis": "dose", "peds_unit": "mg", "peds_note": "Formulary general paediatric dosing for mild to moderate infection: 10 mg/kg per dose twice daily by mouth (immediate release), maximum 500 mg per dose. The formulary's 15 to 20 mg/kg per dose figure is for severe infection and carries a 750 mg per-dose maximum - do not pair 15 mg/kg with a 500 mg cap. Ciprofloxacin is not first-line in children and the formulary gives no paediatric enteric-infection regimen.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 100, "high_mg": 100, "capped": false }, { "weight_kg": 20, "low_mg": 200, "high_mg": 200, "capped": false }, { "weight_kg": 30, "low_mg": 300, "high_mg": 300, "capped": false }, { "weight_kg": 40, "low_mg": 400, "high_mg": 400, "capped": false } ], "brands": [ { "trade_name": "QUINOLOROX 500MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EPCI > ROXXEN", "price_egp": 10.0, "pack_count": 10, "unit_price": 1.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ECACIPROFLOX 500 MG 20 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "FUTURE PHARMACEUTICAL INDUSTRIES (FPI) > EGYPTIAN CANADIAN PHARMACEUTICAL", "price_egp": 27.0, "pack_count": 20, "unit_price": 1.35, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ELMODOXACIN 500MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > SEA PHARM", "price_egp": 20.0, "pack_count": 10, "unit_price": 2.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROQUIN 500MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA", "price_egp": 50.0, "pack_count": 10, "unit_price": 5.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROFLOXACIN-ORGANO 500 MG 10 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANOPHARMA > ORGANO", "price_egp": 63.0, "pack_count": 10, "unit_price": 6.3, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROFAR 500MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 69.0, "pack_count": 10, "unit_price": 6.9, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROMEGA XL 500MG 10 EXT. REL. F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 48.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HEROXACIN 500MG 10 SCORED F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > HERO PHARM", "price_egp": 69.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "shigellosis" }, { "id": 1622, "generic": "Azithromycin", "line": 3, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "500 mg once daily", "adult_duration": "3 days", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023, Azithromycin monograph, PDF page index 267-268 (printed p258-259), \"General dosing, susceptible infection\". Note: this monograph lists no shigellosis or campylobacter indication - the dose shown is the formulary's general azithromycin course, not an indication-matched regimen.", "rationale": "Effective alternative antibiotic for shigellosis, particularly when a fluoroquinolone is undesirable.", "cautions": [ "Paediatric regimen is a day-1 loading dose then a halved daily dose - it cannot be calculated from a single mg/kg figure.", "The Egyptian formulary lists no shigellosis or campylobacter indication for azithromycin; the dose shown is its general susceptible-infection dosing.", "Alternative to ciprofloxacin, useful in pregnancy, children, or where fluoroquinolone resistance or intolerance is a concern.", "QT prolongation risk with other QT-prolonging drugs.", "3-day course; reassess if there is no improvement." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Formulary general dosing for susceptible infection, oral: 10 to 12 mg/kg as a single dose on day 1 (maximum 500 mg), then 5 to 6 mg/kg once daily (maximum 250 mg) for the rest of the course. The day-1 dose and the maintenance dose are different - do not give 10 mg/kg every day. (The flat 10 mg/kg once daily, max 500 mg, is the formulary's intravenous figure.)", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "AZATRIBACT 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RIVA PHARMA S.A.E.", "price_egp": 13.5, "pack_count": 3, "unit_price": 4.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GIGAZOCIN 500MG 5 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > PIONEER", "price_egp": 27.5, "pack_count": 5, "unit_price": 5.5, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SYSTYMYCIN 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > NOVELL PHARMA", "price_egp": 21.5, "pack_count": 3, "unit_price": 7.17, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZITHROMASH 500 MG 3 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 48.0, "pack_count": 3, "unit_price": 16.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZALIDE 500MG 3 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UP PHARMA", "price_egp": 52.0, "pack_count": 3, "unit_price": 17.33, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AZROLID 500 MG 6 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "AMRIYA", "price_egp": 126.0, "pack_count": 6, "unit_price": 21.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZERAMERATE 500 MG", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > GAMMA PHARMA", "price_egp": 28.5, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DISTABCIN 500 MG 3 DISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI", "price_egp": 43.5, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHRODOSE 100MG/5ML SUSP. 15ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL-OBOUR > AVERROES PHARMA-EGYPT", "price_egp": 12.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ZITHROPHATE 200MG/5ML SUSP. 15ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANO PHARMA > NOVELL PHARMA", "price_egp": 12.75, "pack_count": null, "unit_price": null, "strength_mg": 200.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "shigellosis" }, { "id": 1626, "generic": "Ceftriaxone", "line": 3, "is_adjunct": false, "form": "injection", "strength_mg": 1000.0, "adult_dose": "1 to 2 g once daily", "adult_duration": null, "dose_source": "MSF Essential Drugs 2024 (ceftriaxone injectable monograph: \"Severe bacterial infections: septicaemia, meningitis, pneumonia, typhoid fever, shigellosis...\"), with the paediatric shigella course from WHO. The treatment of diarrhoea: a manual for physicians and other senior health workers, 4th rev. Geneva: WHO; 2005, antimicrobial table, Shigella dysentery", "rationale": "The disease article states that for children the WHO recommends ciprofloxacin, pivmecillinam or ceftriaxone. The card carried ciprofloxacin and azithromycin only - no parenteral option for a child who cannot keep oral therapy down. MSF names shigellosis explicitly in ceftriaxone's own indications, and the WHO diarrhoea manual gives the paediatric shigella course. Pivmecillinam, the third WHO option, is NOT on this card: it has no product at all in the Egyptian register, so the row would have carried no brand a Cairo prescriber could dispense.", "cautions": [ "Do not administer to patients with allergy to cephalosporins or penicillins (cross-sensitivity may occur) and to neonates with jaundice (risk of bilirubin encephalopathy) or receiving calcium gluconate.", "Duration varies according to indication and clinical response. Change to oral treatment as soon as possible.", "The solvent containing lidocaine is for IM injection only - DO NOT ADMINISTER BY IV INJECTION OR INFUSION the solution reconstituted with this solvent." ], "peds_mgkg_low": 50.0, "peds_mgkg_high": 100.0, "peds_max_mg": 4000.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "MSF, child 1 month and over and under 50 kg: 50 to 100 mg/kg (maximum 4 g) once daily. The WHO diarrhoea manual gives the shigella course itself: children 50-100 mg/kg once a day IM for 2 to 5 days. Child 50 kg and over is dosed as an adult.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 500, "high_mg": 1000, "capped": false }, { "weight_kg": 20, "low_mg": 1000, "high_mg": 2000, "capped": false }, { "weight_kg": 30, "low_mg": 1500, "high_mg": 3000, "capped": false }, { "weight_kg": 40, "low_mg": 2000, "high_mg": 4000, "capped": false } ], "brands": [ { "trade_name": "ZOXIDEL 1 GM PD. FOR I.M. INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > DELTA PHARMA", "price_egp": 22.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CEFTRIAXONE SODIUM 1 GM I.M.VIAL (KAHIRA)", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 29.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZOXIDEL 1 GM PD. FOR I.V. INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > DELTA PHARMA", "price_egp": 29.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "WINTRIAXONE 1 GM PD. FOR I.V INJ.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 48.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "VOTRIAXONE 1 GM I.M VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CHEMIPHARM", "price_egp": 56.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "OFRAMAX 1 GM I.M. VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > SUN PHARMA EGYPT LIMITED", "price_egp": 71.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TRIAXONE 1 GM I.M. VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "TABUK PHARMACEUTICAL MANUFACTURING COMPANY > TABUK PHARMA", "price_egp": 106.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "TRIAXONE 1 GM I.V VIAL", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "TABUK PHARMACEUTICAL MANUFACTURING COMPANY > TABUK PHARMA", "price_egp": 106.0, "pack_count": null, "unit_price": null, "strength_mg": 1000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "shigellosis" }, { "id": 1627, "generic": "Zinc sulphate", "line": 1, "is_adjunct": true, "form": "oral.solid", "strength_mg": 20.0, "adult_dose": "No adult dose is stated - the indication is limited to children under 5 years (see paediatric dosing)", "adult_duration": null, "dose_source": "MSF Essential Drugs 2024 (zinc sulfate oral monograph: \"Adjunct to oral rehydration therapy in the event of acute and/or persistent diarrhoea in children under 5 years\"), corroborated by WHO. The treatment of diarrhoea: a manual for physicians and other senior health workers, 4th rev. Geneva: WHO; 2005", "rationale": "The disease article says zinc supplements should be given to children with watery diarrhoea; the card carried ORS without it. MSF indicates zinc sulfate as an adjunct to oral rehydration therapy in acute or persistent diarrhoea in children under 5 and gives the doses; the WHO diarrhoea manual recommends 10-20 mg/day for 10 to 14 days for all children with diarrhoea. Named Zinc sulphate rather than MSF's Zinc sulfate because that is how the Egyptian register spells it (6 single-ingredient products); same salt.", "cautions": [ "Zinc sulfate must never replace oral rehydration therapy which is essential (nor can it replace antibiotic therapy that may, in specific cases, be necessary).", "If the child vomits within 30 minutes after swallowing the tablet, re-administer the dose.", "Do not give simultaneously with ferrous salts, administer at least 2 hours apart.", "Place the half-tablet or full tablet in a teaspoon, add a bit of water to dissolve it, and give the entire spoonful to the child." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "MSF: child under 6 months, 10 mg (half a 20 mg dispersible tablet) once daily for 10 days; child from 6 months to 5 years, 20 mg (one tablet) once daily for 10 days. WHO gives the same range over a slightly longer course: 10-20 mg/day for 10 to 14 days.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": [ { "label": "Under 6 months", "age_min_months": 0, "age_max_months": 5, "dose_text": "10 mg (half a 20 mg dispersible tablet) once daily for 10 days" }, { "label": "6 months to 5 years", "age_min_months": 6, "age_max_months": 71, "dose_text": "20 mg (one tablet) once daily for 10 days" } ], "peds_doses": null, "brands": [ { "trade_name": "ZINCOSAFE 11 MG 100 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SAFE PHARMA", "price_egp": 50.0, "pack_count": 100, "unit_price": 0.5, "strength_mg": 11.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZINC STRONG 20 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "NAPCO", "price_egp": 29.0, "pack_count": 20, "unit_price": 1.45, "strength_mg": null, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ARABZINC 50 MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB CAPS > KMT PHARMA", "price_egp": 45.0, "pack_count": 30, "unit_price": 1.5, "strength_mg": 50.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "GREEN & LEAN ZINC 50 MG 30 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "> ALTONA HEALTH", "price_egp": 48.0, "pack_count": 30, "unit_price": 1.6, "strength_mg": 50.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MONO ZINC 20 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB CAPS > BIOMEDA", "price_egp": 41.25, "pack_count": 20, "unit_price": 2.06, "strength_mg": null, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ALL ONE ZINC 50 MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MOZN PHARMACEUTICAL", "price_egp": 80.0, "pack_count": 30, "unit_price": 2.67, "strength_mg": 50.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "OCTOZINC 25 MG 100*10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "OCTOBER PHARMA", "price_egp": 850.0, "pack_count": 10, "unit_price": 85.0, "strength_mg": 25.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZINC PICOLINATE 50 MG 120 VEG. CAPS. (NOW)", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "NOW FOODS > SOFICOPHARM", "price_egp": 1300.0, "pack_count": null, "unit_price": null, "strength_mg": 50.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZINC SULFATE 10MG/5ML POWDER FOR SYRUP", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 5.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "ZINC-SEDICO 10MG/5ML PD. FOR ORAL SOL.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": 10.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "shigellosis" } ] }