GRISEOFULVIN
Formoral.solid
Microsize: 500 mg/day in single or divided doses; for more widespread lesions initial doses of 750 to 1,000 mg/day in single or divided doses may be needed
20-25 mg/kg/day [child max 1000 mg]
(Children >2 years and Adolescents: Microsize: Oral: 20 to 25 mg/kg/day in single or 2 divided doses; maximum daily dose: 1,000 mg/day)
| 3kg | 60-75 mg/day |
|---|---|
| 4kg | 80-100 mg/day |
| 5kg | 100-125 mg/day |
| 6kg | 120-150 mg/day |
| 7kg | 140-175 mg/day |
| 8kg | 160-200 mg/day |
| 9kg | 180-225 mg/day |
| 10kg | 200-250 mg/day |
| 11kg | 220-275 mg/day |
| 12kg | 240-300 mg/day |
| 13kg | 260-325 mg/day |
| 14kg | 280-350 mg/day |
| 15kg | 300-375 mg/day |
| 16kg | 320-400 mg/day |
| 17kg | 340-425 mg/day |
| 18kg | 360-450 mg/day |
| 19kg | 380-475 mg/day |
| 20kg | 400-500 mg/day |
| 21kg | 420-525 mg/day |
| 22kg | 440-550 mg/day |
| 23kg | 460-575 mg/day |
| 24kg | 480-600 mg/day |
| 25kg | 500-625 mg/day |
| 26kg | 520-650 mg/day |
| 27kg | 540-675 mg/day |
| 28kg | 560-700 mg/day |
| 29kg | 580-725 mg/day |
| 30kg | 600-750 mg/day |
| 31kg | 620-775 mg/day |
| 32kg | 640-800 mg/day |
| 33kg | 660-825 mg/day |
| 34kg | 680-850 mg/day |
| 35kg | 700-875 mg/day |
| 36kg | 720-900 mg/day |
| 37kg | 740-925 mg/day |
| 38kg | 760-950 mg/day |
| 39kg | 780-975 mg/day |
| 40kg | 800-1000 mg/day |
| 41kg | 820-1000 mg/day (upper capped) |
| 42kg | 840-1000 mg/day (upper capped) |
| 43kg | 860-1000 mg/day (upper capped) |
| 44kg | 880-1000 mg/day (upper capped) |
| 45kg | 900-1000 mg/day (upper capped) |
| 46kg | 920-1000 mg/day (upper capped) |
| 47kg | 940-1000 mg/day (upper capped) |
| 48kg | 960-1000 mg/day (upper capped) |
| 49kg | 980-1000 mg/day (upper capped) |
| 50kg | 1000 mg/day (capped) |
Egyptian National Drug Formulary, antimicrobial 2023, griseofulvin monograph (printed p. 43)
The only route that reaches the fungus. Tinea capitis lives inside the hair shaft and down in the follicle, where no cream can follow it - oral treatment is not an escalation here, it is the treatment.
- Microsize and ultramicrosize are NOT the same dose. The formulary's 20-25 mg/kg is microsize; ultramicrosize runs about a third lower, and the UK label for its tablets gives 10 mg/kg. Two Egyptian brands are called ULTRAFULVIN and ULTRAGRISEOFULVIN. Read which one is in your hand before you calculate, because guessing here either poisons a child or wastes six weeks.
- The label's paediatric figure is 10 mg/kg/day and the Egyptian formulary's is 20-25. The higher one is used here because it is the tinea-capitis-specific dose; 10 mg/kg is the general minimum for any griseofulvin indication. Scalp infection needs the higher figure.
- After food, and fatty food - whole milk, ice cream, peanut butter. On an empty stomach barely any of it is absorbed, and a failed course is usually a food problem rather than a resistant fungus. Shake the suspension.
- Not in pregnancy, and not in a woman who might conceive within a month of finishing. Men must not father a child for six months after the course.
- It weakens oral contraceptives. Additional precautions throughout and for a month afterwards.
- It photosensitises - keep off intense sun. Monitor liver function; jaundice or rising enzymes can be serious and means stop. Rarely leukopenia: stop if granulocytes fall.
- Watch warfarin and ciclosporin levels alongside it.
- Breastfeeding is not recommended during treatment.
- Contraindicated in hypersensitivity, hepatic failure, porphyria, and pregnancy. Use with caution in lupus erythematosus (risk of exacerbation).
| Egyptian brand | Manufacturer | Indicative price |
|---|---|---|
| ULTRAFULVIN 125MG 25 TAB. | MEMPHIS | 5.00 EGP (0.20/unit) |
| ULTRAGRISEOFULVIN 125 MG 20 TABS. | KAHIRA | 5.50 EGP (0.28/unit) |
| ULTRAGRISEOFULVIN 2.5% SUSP. 100ML? strength differs? different route - not oral solid | KAHIRA | 6.50 EGP |
| GRISEOVIN 2.5% SUSP. 120ML? strength differs? different route - not oral solid | DELTA PHARMA | 7.25 EGP |