{ "schema_version": 1, "kind": "condition", "id": "tuberculosis-referral", "name": "Tuberculosis primary care referral", "category": "infectious", "sources": "Egyptian MOH National Tuberculosis Control Program 2022 for the programme regimen, with the dose from Egyptian National Drug Formulary - Antimicrobial 2023, isoniazid monograph (endf-antimicrobial-2023.txt): \"Once-daily therapy: 5 mg/kg/dose (usual dose: 300 mg) once daily\" for adults and, for children, \"10-15 mg/kg (up to 300 mg) once daily\". · Egyptian MOH National Tuberculosis Control Program 2022 for the programme regimen, with the dose from Egyptian National Drug Formulary - Antimicrobial 2023, rifampicin monograph (endf-antimicrobial-2023.txt): \"Initial intensive phase: 10 mg/kg (maximum dose: 600 mg) once daily\", with the paediatric weight bands \"14 to <20 kg: 300 mg once daily. 20 to <25 kg: 450 mg once daily\" and 600 mg once daily from 25 kg upwards. The formulary's own weight-based paediatric figure is 16 mg/kg/dose below 14 kg, one step above the 15 mg/kg used here. · Egyptian MOH National Tuberculosis Control Program 2022 · WHO Operational Handbook on Tuberculosis 2022", "review_status": "reviewed", "verified_against": "Egyptian MOH National Tuberculosis Control Program 2022 for the programme regimen, with the dose from Egyptian National Drug Formulary - Antimicrobial 2023, isoniazid monograph (endf-antimicrobial-2023.txt): \"Once-daily therapy: 5 mg/kg/dose (usual dose: 300 mg) once daily\" for adults and, for children, \"10-15 mg/kg (up to 300 mg) once daily\". · Egyptian MOH National Tuberculosis Control Program 2022 for the programme regimen, with the dose from Egyptian National Drug Formulary - Antimicrobial 2023, rifampicin monograph (endf-antimicrobial-2023.txt): \"Initial intensive phase: 10 mg/kg (maximum dose: 600 mg) once daily\", with the paediatric weight bands \"14 to <20 kg: 300 mg once daily. 20 to <25 kg: 450 mg once daily\" and 600 mg once daily from 25 kg upwards. The formulary's own weight-based paediatric figure is 16 mg/kg/dose below 14 kg, one step above the 15 mg/kg used here. · Egyptian MOH National Tuberculosis Control Program 2022", "verified_date": "2026-08", "treatments": [ { "id": 1762, "generic": "Rifampicin", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 300.0, "adult_dose": "10 mg/kg once daily (usually 450-600 mg once daily on empty stomach)", "adult_duration": "6 months total regimen (under National TB Program supervision)", "dose_source": "Egyptian MOH National Tuberculosis Control Program 2022 for the programme regimen, with the dose from Egyptian National Drug Formulary - Antimicrobial 2023, rifampicin monograph (endf-antimicrobial-2023.txt): \"Initial intensive phase: 10 mg/kg (maximum dose: 600 mg) once daily\", with the paediatric weight bands \"14 to <20 kg: 300 mg once daily. 20 to <25 kg: 450 mg once daily\" and 600 mg once daily from 25 kg upwards. The formulary's own weight-based paediatric figure is 16 mg/kg/dose below 14 kg, one step above the 15 mg/kg used here.", "rationale": "Essential bactericidal component of standard 4-drug fixed-dose TB regimen", "cautions": [ "REFERRAL MANDATORY: All suspected TB cases must be reported to Chest Clinic / NTP.", "Causes orange-red discoloration of body fluids (urine, tears, sweat).", "Rifampicin is a potent hepatic enzyme inducer; monitor liver function tests at baseline and monthly." ], "peds_mgkg_low": 15.0, "peds_mgkg_high": 15.0, "peds_max_mg": 600.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "15 mg/kg once daily under National TB Program supervision", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 150, "high_mg": 150, "capped": false }, { "weight_kg": 20, "low_mg": 300, "high_mg": 300, "capped": false }, { "weight_kg": 30, "low_mg": 450, "high_mg": 450, "capped": false }, { "weight_kg": 40, "low_mg": 600, "high_mg": 600, "capped": false } ], "brands": [ { "trade_name": "RIFAMPIN 300MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB CAPS", "price_egp": 8.0, "pack_count": 10, "unit_price": 0.8, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RIFABIOTIC 300 MG 8 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 8.0, "pack_count": 8, "unit_price": 1.0, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RIFAMPICIN 300MG 8 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NASR", "price_egp": 9.5, "pack_count": 8, "unit_price": 1.19, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RIFAMPIN 300MG 8 CAPS (MISR)", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR", "price_egp": 9.5, "pack_count": 8, "unit_price": 1.19, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RIMACTANE 300MG 8 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "NOVARTIS", "price_egp": 10.1, "pack_count": 8, "unit_price": 1.26, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RIFAMPIN 300MG 10 CAPS. (DEBEIKY)", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DEBEIKY", "price_egp": 38.5, "pack_count": 10, "unit_price": 3.85, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RIFACTINE 300 MG 8 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 31.0, "pack_count": 8, "unit_price": 3.88, "strength_mg": 300.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "RIFAMOX 100MG/5ML 30GM SUSP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NASR", "price_egp": 4.5, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "RIFAM 100MG/5ML 60ML SUSP.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 7.0, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "tuberculosis-referral" }, { "id": 1763, "generic": "Isoniazid", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 100.0, "adult_dose": "5 mg/kg once daily (usually 300 mg once daily on empty stomach)", "adult_duration": "6 months total regimen (under NTP supervision)", "dose_source": "Egyptian MOH National Tuberculosis Control Program 2022 for the programme regimen, with the dose from Egyptian National Drug Formulary - Antimicrobial 2023, isoniazid monograph (endf-antimicrobial-2023.txt): \"Once-daily therapy: 5 mg/kg/dose (usual dose: 300 mg) once daily\" for adults and, for children, \"10-15 mg/kg (up to 300 mg) once daily\".", "rationale": "Core bactericidal agent paired with rifampicin in short-course chemotherapy", "cautions": [ "REFERRAL MANDATORY: Report all active cases to Egyptian Ministry of Health NTP.", "There is a risk of peripheral neuropathy - co-prescribe pyridoxine (vitamin B6) 10-25 mg daily.", "Monitor for hepatotoxicity (nausea, dark urine, jaundice)." ], "peds_mgkg_low": 10.0, "peds_mgkg_high": 10.0, "peds_max_mg": 300.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "10 mg/kg once daily under National TB Program supervision", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 100, "high_mg": 100, "capped": false }, { "weight_kg": 20, "low_mg": 200, "high_mg": 200, "capped": false }, { "weight_kg": 30, "low_mg": 300, "high_mg": 300, "capped": false }, { "weight_kg": 40, "low_mg": 300, "high_mg": 300, "capped": true } ], "brands": [ { "trade_name": "T.B.ZIDE 100MG 50 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NASR", "price_egp": 13.5, "pack_count": 50, "unit_price": 0.27, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ISOCID 100MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 9.0, "pack_count": 20, "unit_price": 0.45, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ISONIAZID 0.6G/60ML DRY POWDER FOR SYRUP 60ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR", "price_egp": 3.25, "pack_count": null, "unit_price": null, "strength_mg": 600.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "tuberculosis-referral" } ] }