{ "schema_version": 1, "kind": "condition", "id": "urolithiasis-prevention", "name": "Recurrent Urolithiasis (Kidney Stone Prevention)", "category": "chronic", "sources": "DailyMed Allopurinol Tablet Package Insert (DailyMed, NLM) · DailyMed Hydrochlorothiazide Tablet Package Insert (DailyMed, NLM) · DailyMed Urocit-K (Potassium Citrate Extended-Release Tablets) Package Insert (DailyMed, NLM) · EAU Guidelines on Urolithiasis 2023", "review_status": "reviewed", "verified_against": "DailyMed Allopurinol Tablet Package Insert (DailyMed, NLM) · DailyMed Hydrochlorothiazide Tablet Package Insert (DailyMed, NLM) · DailyMed Urocit-K (Potassium Citrate Extended-Release Tablets) Package Insert (DailyMed, NLM) · Urolithiasis - disease-level clinical article (urolithiasis-prevention-clinical.txt)", "verified_date": "2026-08", "treatments": [ { "id": 1821, "generic": "Potassium citrate", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 1080.0, "adult_dose": "1080 mg (10 mEq) three times daily with meals, titrate to maintain urinary pH between 6.2 and 6.8", "adult_duration": "long-term", "dose_source": "DailyMed Urocit-K (Potassium Citrate Extended-Release Tablets) Package Insert (DailyMed, NLM)", "rationale": "Alkalinizes urine to prevent hypocitraturic calcium oxalate, uric acid, and cystine stones", "cautions": [ "CONTRAINDICATED in hyperkalemia, severe renal impairment, and peptic ulcer disease.", "Monitor serum potassium and renal function regularly." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Under pediatric urology/nephrology supervision only", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "KALEMAPEX 10 MEQ (1080 MG) 30 XR TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MULTI-APEX", "price_egp": 187.5, "pack_count": null, "unit_price": null, "strength_mg": 1080.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CITRO-K 1.102G/5ML 120ML SYRUP", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EUROPEAN EGYPTIAN PHARM. IND.", "price_egp": 9.0, "pack_count": null, "unit_price": null, "strength_mg": 1102.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "urolithiasis-prevention" }, { "id": 1822, "generic": "Allopurinol", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 100.0, "adult_dose": "200 mg to 300 mg orally daily in divided doses or as the single equivalent.", "adult_duration": "long-term", "dose_source": "DailyMed Allopurinol Tablet Package Insert (DailyMed, NLM)", "rationale": "Indicated when 24-hour urine demonstrates hyperuricosuria (>800 mg/day in men, >750 mg/day in women)", "cautions": [ "Discontinue immediately if skin rash occurs (risk of severe cutaneous adverse reactions).", "Advise them to increase fluid intake during therapy (i.e., for adults, at least 2 liters of liquids per day) and to stay well hydrated to prevent kidney stones." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist pediatric use only", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "NO-URIC 100 MG 50 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 12.0, "pack_count": 50, "unit_price": 0.24, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "URIC PURE 100MG 50 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEPACO", "price_egp": 13.5, "pack_count": 50, "unit_price": 0.27, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LESSURIC 100MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 6.0, "pack_count": 20, "unit_price": 0.3, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ZYLORIC 100 MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE > ASPEN PHARMA TRADING LIMITED", "price_egp": 39.0, "pack_count": 30, "unit_price": 1.3, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "urolithiasis-prevention" }, { "id": 1823, "generic": "Hydrochlorothiazide", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 25.0, "adult_dose": "25-50 mg once daily in the morning for hypercalciuric calcium stone formers", "adult_duration": "long-term", "dose_source": "DailyMed Hydrochlorothiazide Tablet Package Insert (DailyMed, NLM)", "rationale": "Thiazide diuretic that lowers urinary calcium excretion by increasing distal renal tubular calcium reabsorption; used to prevent recurrent calcium stone formation in patients with hypercalciuria.", "cautions": [ "Reduces urinary calcium excretion by enhancing distal nephron calcium reabsorption.", "Monitor serum potassium (hypokalemia risk) and serum uric acid.", "Restrict dietary sodium intake to optimize hypocalciuric efficacy." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist pediatric nephrology use only", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "HYDROZIDE 25 MG 30 SCORED TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EPCI", "price_egp": 8.0, "pack_count": null, "unit_price": null, "strength_mg": 25.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "urolithiasis-prevention" }, { "id": 1824, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Urolithiasis - disease-level clinical article (urolithiasis-prevention-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Struvite stones largely require surgical intervention rather than the medical/preventive drug therapies on this page, and need close urology follow-up." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "urolithiasis-prevention" } ] }