{ "schema_version": 1, "kind": "condition", "id": "uti-uncomplicated", "name": "Uncomplicated urinary tract infection", "category": "infectious", "sources": "IDSA/ESCMID Cystitis 2011 · Egyptian National Drug Formulary - Antimicrobial 2023 (amoxicillin and clavulanate monograph) · Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560) · Uncomplicated Urinary Tract Infections - disease-level clinical article (uti-uncomplicated-clinical.txt) · Egyptian National Drug Formulary - Antimicrobial 2023 (cephalexin monograph) · Selexid 200 mg Film-coated Tablets (pivmecillinam hydrochloride) SmPC sections 4.1, 4.2, 4.3, 4.4 and 4.6 (eMC product 3799)", "review_status": "reviewed", "verified_against": "IDSA/ESCMID Cystitis 2011 · Egyptian National Drug Formulary - Antimicrobial 2023 (amoxicillin and clavulanate monograph) · Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560) · Uncomplicated Urinary Tract Infections - disease-level clinical article (uti-uncomplicated-clinical.txt) · Egyptian National Drug Formulary - Antimicrobial 2023 (cephalexin monograph) · Selexid 200 mg Film-coated Tablets (pivmecillinam hydrochloride) SmPC sections 4.1, 4.2, 4.3, 4.4 and 4.6 (eMC product 3799)", "verified_date": "2026-08", "treatments": [ { "id": 1844, "generic": "Nitrofurantoin", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 100.0, "adult_dose": "100 mg BID (monohydrate/macrocrystals) or 50 mg QID", "adult_duration": "5 days", "dose_source": "IDSA/ESCMID Cystitis 2011", "rationale": "Urinary antiseptic antibiotic concentrated in the urine; first-line treatment for uncomplicated cystitis given low resistance rates and minimal effect on gut flora.", "cautions": [ "Contraindicated if eGFR < 45 mL/min.", "Take with food to improve absorption and lessen GI upset.", "Pulmonary toxicity can occur on prolonged use; urine turns brown." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Specialist use only in children; 5-7 mg/kg/day divided QID", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "COLIFURAN 100 MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 2.4, "pack_count": 20, "unit_price": 0.12, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "UVAMINE RETARD 100 MG 20 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP > ACINO", "price_egp": 47.0, "pack_count": 20, "unit_price": 2.35, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MEPAFURAN 100 MG 20 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEPACO", "price_egp": 54.0, "pack_count": 20, "unit_price": 2.7, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MACROFURAN 100 MG 30 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA", "price_egp": 82.0, "pack_count": 30, "unit_price": 2.73, "strength_mg": 100.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "uti-uncomplicated" }, { "id": 1846, "generic": "Fosfomycin", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 3000.0, "adult_dose": "3 g single dose dissolved in water before bedtime on empty stomach", "adult_duration": "single-dose", "dose_source": "IDSA/ESCMID Cystitis 2011", "rationale": "Phosphonic acid antibiotic that inhibits an early step of bacterial cell wall synthesis; an option for uncomplicated cystitis valued for its simple regimen that improves adherence.", "cautions": [ "Dissolve sachet in 3-4 oz water and drink immediately on empty stomach.", "Single-dose regimen improves compliance.", "Headache, diarrhea, and nausea are reported." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Not established in children under 12 years", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "FOSFORON 3GM 1 SACHET", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLOBE INTERNATIONAL PHARMACEUTICALS", "price_egp": 39.0, "pack_count": null, "unit_price": null, "strength_mg": 3000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MONURIL 3GM 1 SACHET", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ZAMBON > PHARMACON", "price_egp": 293.0, "pack_count": null, "unit_price": null, "strength_mg": 3000.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "uti-uncomplicated" }, { "id": 1850, "generic": "Referral & safety-netting (no drug therapy)", "line": 1, "is_adjunct": false, "form": null, "strength_mg": null, "adult_dose": null, "adult_duration": null, "dose_source": "Uncomplicated Urinary Tract Infections - disease-level clinical article (uti-uncomplicated-clinical.txt)", "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.", "cautions": [ "RED FLAG - Fever, chills, nausea, vomiting, or back or flank pain indicates pyelonephritis or upper tract involvement." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": null, "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "uti-uncomplicated" }, { "id": 1851, "generic": "Cefalexin", "line": 1, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "250-1000 mg every 6 hours, or 500 mg every 12 hours (maximum 4 g/day)", "adult_duration": null, "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (cephalexin monograph)", "rationale": "The disease article names first-generation cephalosporins as a first-line option; nitrofurantoin remains the card's printed first choice and nothing is re-ranked by adding this alternative.", "cautions": [ "Hypersensitivity to cephalexin, other cephalosporins, or any component of the formulation", "Tablets and oral suspension are not bioequivalent; do not substitute on a mg-per-mg basis.", "CrCl 30 to 59 mL/minute: maximum recommended daily dose 1,000 mg/day", "The ENDF cephalexin monograph gives no cystitis-specific course length - duration is not stated here because the dosing document does not state one." ], "peds_mgkg_low": 25.0, "peds_mgkg_high": 50.0, "peds_max_mg": 2000.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "ENDF: mild to moderate infection, 25 to 50 mg/kg/day divided every 6 or 12 hours; maximum daily dose 2,000 mg/day.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 250, "high_mg": 500, "capped": false }, { "weight_kg": 20, "low_mg": 500, "high_mg": 1000, "capped": false }, { "weight_kg": 30, "low_mg": 750, "high_mg": 1500, "capped": false }, { "weight_kg": 40, "low_mg": 1000, "high_mg": 2000, "capped": false } ], "brands": [ { "trade_name": "CEFLODIX 500 MG 12 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB CAPS > PHAROPHARMA", "price_egp": 9.0, "pack_count": 12, "unit_price": 0.75, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CEPHALEXCID 500 MG 12 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 10.3, "pack_count": 12, "unit_price": 0.86, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CEPHOXIN 500MG 12 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO B", "price_egp": 10.5, "pack_count": 12, "unit_price": 0.88, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CEPHALEXIN 500MG 10 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 10.1, "pack_count": 10, "unit_price": 1.01, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MEDICEFLEXIN 500 MG 20 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "T3A PHARMA > RIVA PHARMA S.A.E.", "price_egp": 25.25, "pack_count": 20, "unit_price": 1.26, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CEPHALEXIN 500MG 12 CAPS B.P.2007", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SHIFA MEDICAL PRODUCTS > OCTOBER PHARMA", "price_egp": 27.0, "pack_count": 12, "unit_price": 2.25, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "KEFLEX 500 MG 12 CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "HIKMA PHARMA", "price_egp": 58.0, "pack_count": 12, "unit_price": 4.83, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CEPOREX 500MG 12 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE", "price_egp": 69.0, "pack_count": 12, "unit_price": 5.75, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AMTHROST 125MG/5ML SUSP. 60ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA > SABAA", "price_egp": 4.0, "pack_count": null, "unit_price": null, "strength_mg": 125.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "AMTHROST 250MG/5ML SUSP. 60ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA > SABAA", "price_egp": 4.5, "pack_count": null, "unit_price": null, "strength_mg": 250.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "uti-uncomplicated" }, { "id": 1845, "generic": "Sulphamethoxazole + Trimethoprim", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 960.0, "adult_dose": "960 mg (1 double strength tab) BID", "adult_duration": "3 days", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023", "rationale": "Held at second line, for culture-guided use only. The cited disease article sets a threshold for this combination specifically - avoid it where local bacterial resistance passes 20%, or in sulfa allergy - which is stricter than its general rule. No Egyptian E. coli resistance figure appears in the cited sources, so this drug is not used empirically.", "cautions": [ "Use only where a culture supports it. The cited disease article says this combination should be avoided where local bacterial resistance passes 20%, or in patients with a sulfa allergy. No Egyptian E. coli resistance figure appears in the cited sources.", "Contraindicated in severe renal impairment and sulfa allergy.", "There is a risk of Stevens-Johnson syndrome and hyperkalemia." ], "peds_mgkg_low": 24.0, "peds_mgkg_high": 36.0, "peds_max_mg": 1920.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "Divided BID for 3 days", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 240, "high_mg": 360, "capped": false }, { "weight_kg": 20, "low_mg": 480, "high_mg": 720, "capped": false }, { "weight_kg": 30, "low_mg": 720, "high_mg": 1080, "capped": false }, { "weight_kg": 40, "low_mg": 960, "high_mg": 1440, "capped": false } ], "brands": [ { "trade_name": "CO-TRIMOXAZOLE 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 5.0, "pack_count": 20, "unit_price": 0.25, "strength_mg": null, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "COTRIL 400/80MG 20 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EL NASR", "price_egp": 38.0, "pack_count": 20, "unit_price": 1.9, "strength_mg": 80.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SEPTAZOLE FORTE 800/160MG 20 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 56.0, "pack_count": 20, "unit_price": 2.8, "strength_mg": 160.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SEPTRIN D.S 10 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "GLAXO SMITHKLINE > ASPEN PHARMA TRADING LIMITED", "price_egp": 28.0, "pack_count": 10, "unit_price": 2.8, "strength_mg": null, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SEPTAZOLE 400/80MG 20*10 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ALEXANDRIA", "price_egp": 340.0, "pack_count": 10, "unit_price": 34.0, "strength_mg": 80.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "SUTRIM 400/80MG 20*10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 340.0, "pack_count": 10, "unit_price": 34.0, "strength_mg": 80.0, "exact_strength": false, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CO-TRIMOXAZOLE 200/40MG SUSP. 120ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP", "price_egp": 6.0, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "SUTRIM 200/40MG SUSP. 100ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MEMPHIS", "price_egp": 18.5, "pack_count": null, "unit_price": null, "strength_mg": 40.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "uti-uncomplicated" }, { "id": 1847, "generic": "Ciprofloxacin", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 500.0, "adult_dose": "250-500 mg BID", "adult_duration": "3 days", "dose_source": "IDSA/ESCMID Cystitis 2011", "rationale": "Held at second line for uncomplicated cystitis, reserved for complicated cases or treatment failure, and subject to the Egyptian Drug Authority's fluoroquinolone safety restrictions. The cited disease article gives no quinolone-specific threshold - only a general rule for E. coli, to switch antibiotic once local resistance passes 50%. No Egyptian quinolone resistance figure appears in the cited sources.", "cautions": [ "Reserve fluoroquinolones for complicated cases or failure.", "Avoid with antacids or iron supplements.", "There are tendonitis and QT prolongation risks." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Contraindicated in children due to joint toxicity", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "QUINOLOROX 500MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EPCI > ROXXEN", "price_egp": 10.0, "pack_count": 10, "unit_price": 1.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ECACIPROFLOX 500 MG 20 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "FUTURE PHARMACEUTICAL INDUSTRIES (FPI) > EGYPTIAN CANADIAN PHARMACEUTICAL", "price_egp": 27.0, "pack_count": 20, "unit_price": 1.35, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ELMODOXACIN 500MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > SEA PHARM", "price_egp": 20.0, "pack_count": 10, "unit_price": 2.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROQUIN 500MG 10 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "UNIPHARMA", "price_egp": 50.0, "pack_count": 10, "unit_price": 5.0, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROFLOXACIN-ORGANO 500 MG 10 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ORGANOPHARMA > ORGANO", "price_egp": 63.0, "pack_count": 10, "unit_price": 6.3, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROFAR 500MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 69.0, "pack_count": 10, "unit_price": 6.9, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CIPROMEGA XL 500MG 10 EXT. REL. F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MASH PREMIERE", "price_egp": 48.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "HEROXACIN 500MG 10 SCORED F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EGPI > HERO PHARM", "price_egp": 69.0, "pack_count": null, "unit_price": null, "strength_mg": 500.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null } ], "condition_id": "uti-uncomplicated" }, { "id": 1848, "generic": "Amoxicillin + Clavulanic acid", "line": 2, "is_adjunct": false, "form": "oral.solid", "strength_mg": 625.0, "adult_dose": "500/125 mg twice daily", "adult_duration": "5-7 days", "dose_source": "Egyptian National Drug Formulary - Antimicrobial 2023 (amoxicillin and clavulanate monograph)", "rationale": "The Egyptian EML 2025 names amoxicillin + clavulanic acid a first-choice antibiotic for lower urinary tract infections, alongside nitrofurantoin and co-trimoxazole. It is the practical first-line in pregnancy, where the formulary contraindicates nitrofurantoin in a pregnancy at term - 38 to 42 weeks - and during labour and delivery, and says of co-trimoxazole that some guidelines recommend keeping away from it in the third trimester. The formulary's own cystitis dose is 500 mg twice daily.", "cautions": [ "An Access-group antibiotic and an Egyptian EML first choice for lower UTI - it does not need justifying the way a quinolone does.", "Avoid in penicillin allergy; avoid if there has been previous cholestatic jaundice with this drug.", "Diarrhoea is commoner than with amoxicillin alone; take with food.", "Reduce the dose if creatinine clearance is below 30 mL/min." ], "peds_mgkg_low": 25.0, "peds_mgkg_high": 45.0, "peds_max_mg": 1750.0, "peds_basis": "day", "peds_unit": "mg", "peds_note": "Of the amoxicillin component, divided twice daily using a 7:1 suspension (200/28.5 or 400/57 mg per 5 mL); maximum 1750 mg/day. Do not give the 250 mg film-coated tablet to a child under 40 kg - the clavulanate share is too high.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": [ { "weight_kg": 10, "low_mg": 250, "high_mg": 450, "capped": false }, { "weight_kg": 20, "low_mg": 500, "high_mg": 900, "capped": false }, { "weight_kg": 30, "low_mg": 750, "high_mg": 1350, "capped": false }, { "weight_kg": 40, "low_mg": 1000, "high_mg": 1750, "capped": true } ], "brands": [ { "trade_name": "AUJED 625 MG 12 F.C. TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SIGMA TEC > JEDCO INT. CO. FOR PHARMACEUTICALS", "price_egp": 19.2, "pack_count": 12, "unit_price": 1.6, "strength_mg": 625.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "E-MOXCLAV 625MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 30.0, "pack_count": 10, "unit_price": 3.0, "strength_mg": 625.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "DEXICLAVE 625 MG 12 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > NOVELL PHARMA", "price_egp": 37.5, "pack_count": 12, "unit_price": 3.12, "strength_mg": 625.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MAGNABIOTIC 625MG 8 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 37.0, "pack_count": 8, "unit_price": 4.62, "strength_mg": 625.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLAVIMOX 625 MG 12 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "PHARCO", "price_egp": 107.0, "pack_count": 12, "unit_price": 8.92, "strength_mg": 625.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CURAM 625MG 12 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANDOZ > NOVARTIS", "price_egp": 108.0, "pack_count": 12, "unit_price": 9.0, "strength_mg": 625.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "AUGMENTIN 625 MG 10 F.C.TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MUP > SMITHKLINE BEECHAM", "price_egp": 117.0, "pack_count": 10, "unit_price": 11.7, "strength_mg": 625.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "CLAVOCILLIN 625 MG 10 DISPERSIBLE TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "RAMEDA > ORGANOPHARMA", "price_egp": 31.5, "pack_count": null, "unit_price": null, "strength_mg": 625.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "LARYNCLAVE 125/31 PD. FOR ORAL SUSP. 70ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "MISR > AL ROWAD PHARMACEUTICAL INDUSTRIAL CO.", "price_egp": 8.0, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "MEGACLAVOX 156MG/5ML PD. FOR SUSP. 60 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "CID", "price_egp": 8.0, "pack_count": null, "unit_price": null, "strength_mg": 156.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "uti-uncomplicated" }, { "id": 1852, "generic": "Pivmecillinam", "line": 3, "is_adjunct": false, "form": "oral.solid", "strength_mg": 200.0, "adult_dose": "A three-day course with a double first dose. SmPC verbatim: \"Acute uncomplicated cystitis: 72 hour course of 2 tablets immediately followed by 1 tablet 3 times daily to a total of 10 tablets.\" On 200 mg tablets that is 400 mg once, then 200 mg three times a day. For a bacteriuria that keeps returning the SmPC gives a heavier regimen: \"Chronic or recurrent bacteriuria: 2 tablets three to four times daily.\"", "adult_duration": "Three days. SmPC verbatim: a \"72 hour course\" totalling ten tablets.", "dose_source": "Selexid 200 mg Film-coated Tablets (pivmecillinam hydrochloride) SmPC sections 4.1, 4.2, 4.3, 4.4 and 4.6 (eMC product 3799)", "rationale": "The disease article names the drug twice and says where it sits, verbatim: \"Pivmecilinam may be considered when other agents cannot be used due to resistance or other factors, although it is not typically preferred for long-term use.\" and \"Pivmecillinam is better tolerated than nitrofurantoin, and it effectively covers ESBL-producing and multiple drug-resistant strains of E coli, P mirabilis, and S saprophyticus.\" The SmPC's indication section names urinary tract infections and its posology names the syndrome, verbatim: \"Acute uncomplicated cystitis\". ESBL-producing E coli is common in Cairo and the card's existing options narrow quickly against it. Egypt registers no pivmecillinam product, so no brand and no price can be shown.", "cautions": [ "Contraindicated in more than the obvious group. SmPC verbatim: \"Hypersensitivity to penicillins and/or cephalosporins. Any conditions resulting in impaired transit through the oesophagus.\" and \"Genetic metabolism anomalies known to be leading to severe carnitine deficiency, such as carnitine transporter defect, methylmalonic aciduria or propionic acidaemia.\"", "Take it upright, with fluid and food. SmPC verbatim: \"The tablets must be taken with at least half a glass of fluid, and preferably taken with or immediately after a meal.\" The oesophageal contraindication above is the reason this instruction carries weight.", "Severe skin reactions end the course. SmPC verbatim: \"Severe cutaneous adverse reactions (SCAR) such as acute generalized exanthematous pustulosis (AGEP), drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) have been reported in relation to beta-lactam treatment, including Selexid. When SCAR is suspected, Selexid should be discontinued immediately\".", "It depletes carnitine, and valproate makes that worse. SmPC verbatim: \"Selexid tablets should be used with caution for long-term or frequently-repeated treatment, due to the possibility of carnitine depletion. Symptoms of carnitine depletion include muscle aches, fatigue, and confusion.\" and \"Concurrent treatment with valproic acid, valproate or other medication liberating pivalic acid should be avoided due to increased risk of carnitine depletion.\"", "Caution in porphyria. SmPC verbatim: \"Selexid tablets should be used with caution in patients with porphyria since pivmecillinam has been associated with acute attacks of porphyria.\"", "It does not cover the gram-positive urinary organisms. The disease article does not recommend it against Pseudomonas, Acinetobacter or Enterococcus, nor against the other gram-positive urinary pathogens. A culture growing enterococcus is a reason to change, not to continue.", "Watch for antibiotic-associated colitis. SmPC verbatim: \"Pseudomembranous colitis caused by Clostridium difficile may occur. If diarrhoea occurs after use, the possibility of pseudomembranous colitis should be considered\"." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "The SmPC doses children by weight but this is not a first move in a child. Verbatim: \"Children weighing more than 40 kg\" take the adult 72-hour course; \"Children weighing less than 40 kg Urinary tract infections: 20-40 mg/kg body weight, daily, in 3 to 4 divided doses.\" No worked milligram table is printed here on purpose - a urinary infection in a small child needs the cause looked for, not a second-choice antibiotic reached for.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [], "condition_id": "uti-uncomplicated" }, { "id": 1849, "generic": "Ibuprofen", "line": 1, "is_adjunct": true, "form": "oral.solid", "strength_mg": 400.0, "adult_dose": "400 mg three times daily with or after food, maximum 1200 mg in 24 hours", "adult_duration": "up to 3 days for the dysuria", "dose_source": "Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560)", "rationale": "The EAU urological infections guideline gives a strong recommendation to offer non-antibiotic therapy as an alternative in non-geriatric patients with uncomplicated cystitis, and names ibuprofen and diclofenac as the NSAIDs shown to reduce antibiotic use. The guideline states no dose, so the dose here is the drug label's.", "cautions": [ "EAU frames the NSAID as an alternative to an antibiotic in a well non-elderly woman, not as an add-on. Symptom relief is less complete than with an antibiotic.", "EAU says there is no evidence for NSAID symptomatic treatment in geriatric patients and that NSAIDs are potentially inappropriate in that age group.", "Avoid in asthma, active peptic ulcer, and in renal impairment - which also means: not if you suspect this is pyelonephritis rather than cystitis.", "Contraindicated in the third trimester of pregnancy." ], "peds_mgkg_low": null, "peds_mgkg_high": null, "peds_max_mg": null, "peds_basis": null, "peds_unit": null, "peds_note": "Uncomplicated cystitis in this entry is an adult presentation. A child with a urinary infection needs the paediatric UTI pathway, not this row.", "peds_min_weight_kg": null, "peds_max_weight_kg": null, "peds_age_min_months": null, "peds_age_max_months": null, "peds_age_bands": null, "peds_doses": null, "brands": [ { "trade_name": "DAJUANOFEN 400 MG 20 F.C. TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "COPAD PHARMA", "price_egp": 5.0, "pack_count": 20, "unit_price": 0.25, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "FLABU 400MG 10 F.C.TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "DELTA PHARMA", "price_egp": 3.75, "pack_count": 10, "unit_price": 0.38, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NOVA-PROFEN 400MG 30 F.C. TABLETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 12.75, "pack_count": 30, "unit_price": 0.42, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "IBUPROFEN 400 MG 10 TAB.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SEDICO", "price_egp": 6.0, "pack_count": 10, "unit_price": 0.6, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "MAFO 400 MG 30 F.C.TABS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EIPICO", "price_egp": 42.0, "pack_count": 30, "unit_price": 1.4, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "BRUFEN 400 MG 30 TABS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "KAHIRA > ABBOTT LABORATORIES", "price_egp": 78.0, "pack_count": 30, "unit_price": 2.6, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "PROFUSOL 400MG 20 S.G CAPS.", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EUROPEAN EGYPTIAN PHARM. IND.", "price_egp": 31.0, "pack_count": null, "unit_price": null, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "ANALGIPROF 400 MG 25 SACHETS", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "EVA PHARMA", "price_egp": 37.5, "pack_count": null, "unit_price": null, "strength_mg": 400.0, "exact_strength": true, "exact_form": true, "discontinued": false, "also_contains": null }, { "trade_name": "NOVA-PROFEN 100MG/5ML ORAL SUSP. 100ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "SANOFI", "price_egp": 2.25, "pack_count": null, "unit_price": null, "strength_mg": 100.0, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null }, { "trade_name": "BRUFEMOL-N SUSP. 60 ML", "scientific_name": null, "normalized_ingredient": null, "manufacturer": "ARAB DRUG COMPANY (ADCO)", "price_egp": 4.5, "pack_count": null, "unit_price": null, "strength_mg": null, "exact_strength": false, "exact_form": false, "discontinued": false, "also_contains": null } ], "condition_id": "uti-uncomplicated" } ] }