# Uncomplicated urinary tract infection - Category: infectious - Review status: reviewed (every claim checked against a document named on this page) - Sources: IDSA/ESCMID Cystitis 2011 · Egyptian National Drug Formulary - Antimicrobial 2023 (amoxicillin and clavulanate monograph) · Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560) · Uncomplicated Urinary Tract Infections - disease-level clinical article (uti-uncomplicated-clinical.txt) · Egyptian National Drug Formulary - Antimicrobial 2023 (cephalexin monograph) · Selexid 200 mg Film-coated Tablets (pivmecillinam hydrochloride) SmPC sections 4.1, 4.2, 4.3, 4.4 and 4.6 (eMC product 3799) - Verified date: 2026-08 ## Verified against - IDSA/ESCMID Cystitis 2011 - Egyptian National Drug Formulary - Antimicrobial 2023 (amoxicillin and clavulanate monograph) - Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560) - Uncomplicated Urinary Tract Infections - disease-level clinical article (uti-uncomplicated-clinical.txt) - Egyptian National Drug Formulary - Antimicrobial 2023 (cephalexin monograph) - Selexid 200 mg Film-coated Tablets (pivmecillinam hydrochloride) SmPC sections 4.1, 4.2, 4.3, 4.4 and 4.6 (eMC product 3799) ## Treatment metadata - Nitrofurantoin — 100 mg — oral.solid - Fosfomycin — 3000 mg — oral.solid - Referral & safety-netting (no drug therapy) - Cefalexin — 500 mg — oral.solid - Sulphamethoxazole + Trimethoprim — 960 mg — oral.solid - Ciprofloxacin — 500 mg — oral.solid - Amoxicillin + Clavulanic acid — 625 mg — oral.solid - Pivmecillinam — 200 mg — oral.solid - Ibuprofen — 400 mg — oral.solid ## Complete treatment card ```text UNCOMPLICATED URINARY TRACT INFECTION Sources: IDSA/ESCMID Cystitis 2011 · Egyptian National Drug Formulary - Antimicrobial 2023 (amoxicillin and clavulanate monograph) · Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560) · Uncomplicated Urinary Tract Infections - disease-level clinical article (uti-uncomplicated-clinical.txt) · Egyptian National Drug Formulary - Antimicrobial 2023 (cephalexin monograph) · Selexid 200 mg Film-coated Tablets (pivmecillinam hydrochloride) SmPC sections 4.1, 4.2, 4.3, 4.4 and 4.6 (eMC product 3799) Review status: REVIEWED against 5 sources listed above (2026-08) IS IT THIS? - reference only, to read alongside your own examination SYMPTOMS - what the patient reports (5) - Dysuria, frequency, hesitancy, urgency, suprapubic discomfort, and bladder spasms are typical uncomplicated UTI symptoms [abdominal pain · burning on passing urine · lower abdominal pain · poor urinary stream · spasm · urinary frequency · urinary urgency] - Fever, chills, nausea, vomiting, or flank pain point away from simple cystitis toward pyelonephritis [abdominal pain · chills · fever · loin pain · nausea · vomiting] - A patient with multiple sclerosis may present atypically with worsening neurologic symptoms instead of classic urinary complaints - In older adults, new confusion or disorganized speech may be the presenting sign instead of classic urinary symptoms [confusion] - Severe hypertension with a headache can signal a UTI in a patient with a spinal cord injury at T-6 or above [headache · hypertension] SIGNS - what you find (1) - The exam is usually unremarkable, though suprapubic tenderness turns up in 10 to 20% of cases [abdominal pain · lower abdominal pain] TESTS (5) - A positive nitrite dipstick is highly specific (92 to 100%) but has low sensitivity (19 to 48%) for a UTI - A UTI is strongly suggested when a well-collected sample shows over 10 white cells per high- power field - A UTI is diagnosed when a single organism reaches 1000 CFU/mL or more on culture from a symptomatic patient - As many as 40% of women with a UTI may show a colony count of 10,000 CFU/mL or less - Cystoscopy and urinary tract imaging are not routinely needed for a straightforward uncomplicated UTI IF NOT THIS - what else fits (4) - Sexually transmitted infections are on the differential for uncomplicated UTI-type symptoms - Pelvic inflammatory disease is also on the differential list - A medication side effect can produce urinary symptoms that mimic a UTI - Herpes simplex infection can cause dysuria that mimics a UTI Source StatPearls "Uncomplicated Urinary Tract Infections" - disease-level clinical article Status traced to the source above Rx: Antibiotic | Main treatment | Oral option where resistance rules the usual agents out - no Egyptian product registered | Pain ANTIBIOTIC - choose one 1. NITROFURANTOIN [1st line] Adult 100 mg BID (monohydrate/macrocrystals) or 50 mg QID x 5 days Peds Specialist use only in children; 5-7 mg/kg/day divided QID Choice Alternatives. Nitrofurantoin is first-line for uncomplicated cystitis; fosfomycin's single dose is its advantage but it is far less widely stocked. Source IDSA/ESCMID Cystitis 2011 Why Urinary antiseptic antibiotic concentrated in the urine; first-line treatment for uncomplicated cystitis given low resistance rates and minimal effect on gut flora. Caution Contraindicated if eGFR < 45 mL/min. Take with food to improve absorption and lessen GI upset. Pulmonary toxicity can occur on prolonged use; urine turns brown. Egypt COLIFURAN 100 MG 20 TABS. KAHIRA 2.40 EGP (0.12/unit) UVAMINE RETARD 100 MG 20 CAPS. MUP > ACINO 47.00 EGP (2.35/unit) MEPAFURAN 100 MG 20 CAPS. MEPACO 54.00 EGP (2.70/unit) MACROFURAN 100 MG 30 CAPS. KAHIRA 82.00 EGP (2.73/unit) 2. FOSFOMYCIN [1st line] Adult 3 g single dose dissolved in water before bedtime on empty stomach - single-dose Peds Not established in children under 12 years Source IDSA/ESCMID Cystitis 2011 Why Phosphonic acid antibiotic that inhibits an early step of bacterial cell wall synthesis; an option for uncomplicated cystitis valued for its simple regimen that improves adherence. Caution Dissolve sachet in 3-4 oz water and drink immediately on empty stomach. Single-dose regimen improves compliance. Headache, diarrhea, and nausea are reported. Egypt FOSFORON 3GM 1 SACHET GLOBE INTERNA... 39.00 EGP MONURIL 3GM 1 SACHET ZAMBON > PHAR... 293.00 EGP 3. CEFALEXIN [1st line] Adult 250-1000 mg every 6 hours, or 500 mg every 12 hours (maximum 4 g/day) Peds 25-50 mg/kg/day [child max 2000 mg] (ENDF: mild to moderate infection, 25 to 50 mg/kg/day divided every 6 or 12 hours; maximum daily dose 2,000 mg/day.) 3kg -> 75-150 mg/day 4kg -> 100-200 mg/day 5kg -> 125-250 mg/day 6kg -> 150-300 mg/day 7kg -> 175-350 mg/day 8kg -> 200-400 mg/day 9kg -> 225-450 mg/day 10kg -> 250-500 mg/day 11kg -> 275-550 mg/day 12kg -> 300-600 mg/day 13kg -> 325-650 mg/day 14kg -> 350-700 mg/day 15kg -> 375-750 mg/day 16kg -> 400-800 mg/day 17kg -> 425-850 mg/day 18kg -> 450-900 mg/day 19kg -> 475-950 mg/day 20kg -> 500-1000 mg/day 21kg -> 525-1050 mg/day 22kg -> 550-1100 mg/day 23kg -> 575-1150 mg/day 24kg -> 600-1200 mg/day 25kg -> 625-1250 mg/day 26kg -> 650-1300 mg/day 27kg -> 675-1350 mg/day 28kg -> 700-1400 mg/day 29kg -> 725-1450 mg/day 30kg -> 750-1500 mg/day 31kg -> 775-1550 mg/day 32kg -> 800-1600 mg/day 33kg -> 825-1650 mg/day 34kg -> 850-1700 mg/day 35kg -> 875-1750 mg/day 36kg -> 900-1800 mg/day 37kg -> 925-1850 mg/day 38kg -> 950-1900 mg/day 39kg -> 975-1950 mg/day 40kg -> 1000-2000 mg/day 41kg -> 1025-2000 mg/day (upper capped) 42kg -> 1050-2000 mg/day (upper capped) 43kg -> 1075-2000 mg/day (upper capped) 44kg -> 1100-2000 mg/day (upper capped) 45kg -> 1125-2000 mg/day (upper capped) 46kg -> 1150-2000 mg/day (upper capped) 47kg -> 1175-2000 mg/day (upper capped) 48kg -> 1200-2000 mg/day (upper capped) 49kg -> 1225-2000 mg/day (upper capped) 50kg -> 1250-2000 mg/day (upper capped) Source Egyptian National Drug Formulary - Antimicrobial 2023 (cephalexin monograph) Why The disease article names first-generation cephalosporins as a first-line option; nitrofurantoin remains the card's printed first choice and nothing is re-ranked by adding this alternative. Caution Hypersensitivity to cephalexin, other cephalosporins, or any component of the formulation Tablets and oral suspension are not bioequivalent; do not substitute on a mg-per-mg basis. CrCl 30 to 59 mL/minute: maximum recommended daily dose 1,000 mg/day The ENDF cephalexin monograph gives no cystitis-specific course length - duration is not stated here because the dosing document does not state one. Egypt CEFLODIX 500 MG 12 CAPS. ARAB CAPS > P... 9.00 EGP (0.75/unit) CEPHALEXCID 500 MG 12 CAPS. CID 10.30 EGP (0.86/unit) CEPHOXIN 500MG 12 TAB. PHARCO B 10.50 EGP (0.88/unit) CEPHALEXIN 500MG 10 CAPS. ARAB DRUG COM... 10.10 EGP (1.01/unit) MEDICEFLEXIN 500 MG 20 CAPS. T3A PHARMA > ... 25.25 EGP (1.26/unit) CEPHALEXIN 500MG 12 CAPS B.P.2007 SHIFA MEDICAL PRODUCTS > O... 27.00 EGP (2.25/unit) KEFLEX 500 MG 12 CAPS. HIKMA PHARMA 58.00 EGP (4.83/unit) CEPOREX 500MG 12 TABS. GLAXO SMITHKLINE 69.00 EGP (5.75/unit) AMTHROST 125MG/5ML SUSP. 60ML SIGMA > SABAA 4.00 EGP -> ? strength differs, ? different route - not oral solid AMTHROST 250MG/5ML SUSP. 60ML SIGMA > SABAA 4.50 EGP -> ? strength differs, ? different route - not oral solid 4. SULPHAMETHOXAZOLE + TRIMETHOPRIM [2nd line] Adult 960 mg (1 double strength tab) BID x 3 days Peds 24-36 mg/kg/day [child max 1920 mg] (Divided BID for 3 days) 3kg -> 72-108 mg/day 4kg -> 96-144 mg/day 5kg -> 120-180 mg/day 6kg -> 144-216 mg/day 7kg -> 168-252 mg/day 8kg -> 192-288 mg/day 9kg -> 216-324 mg/day 10kg -> 240-360 mg/day 11kg -> 264-396 mg/day 12kg -> 288-432 mg/day 13kg -> 312-468 mg/day 14kg -> 336-504 mg/day 15kg -> 360-540 mg/day 16kg -> 384-576 mg/day 17kg -> 408-612 mg/day 18kg -> 432-648 mg/day 19kg -> 456-684 mg/day 20kg -> 480-720 mg/day 21kg -> 504-756 mg/day 22kg -> 528-792 mg/day 23kg -> 552-828 mg/day 24kg -> 576-864 mg/day 25kg -> 600-900 mg/day 26kg -> 624-936 mg/day 27kg -> 648-972 mg/day 28kg -> 672-1008 mg/day 29kg -> 696-1044 mg/day 30kg -> 720-1080 mg/day 31kg -> 744-1116 mg/day 32kg -> 768-1152 mg/day 33kg -> 792-1188 mg/day 34kg -> 816-1224 mg/day 35kg -> 840-1260 mg/day 36kg -> 864-1296 mg/day 37kg -> 888-1332 mg/day 38kg -> 912-1368 mg/day 39kg -> 936-1404 mg/day 40kg -> 960-1440 mg/day 41kg -> 984-1476 mg/day 42kg -> 1008-1512 mg/day 43kg -> 1032-1548 mg/day 44kg -> 1056-1584 mg/day 45kg -> 1080-1620 mg/day 46kg -> 1104-1656 mg/day 47kg -> 1128-1692 mg/day 48kg -> 1152-1728 mg/day 49kg -> 1176-1764 mg/day 50kg -> 1200-1800 mg/day Source Egyptian National Drug Formulary - Antimicrobial 2023 Why Held at second line, for culture-guided use only. The cited disease article sets a threshold for this combination specifically - avoid it where local bacterial resistance passes 20%, or in sulfa allergy - which is stricter than its general rule. No Egyptian E. coli resistance figure appears in the cited sources, so this drug is not used empirically. Caution Use only where a culture supports it. The cited disease article says this combination should be avoided where local bacterial resistance passes 20%, or in patients with a sulfa allergy. No Egyptian E. coli resistance figure appears in the cited sources. Contraindicated in severe renal impairment and sulfa allergy. There is a risk of Stevens-Johnson syndrome and hyperkalemia. Egypt CO-TRIMOXAZOLE 20 TABS. MUP 5.00 EGP (0.25/unit) -> ? strength differs COTRIL 400/80MG 20 TAB. EL NASR 38.00 EGP (1.90/unit) -> ? strength differs SEPTAZOLE FORTE 800/160MG 20 TABS. ALEXANDRIA 56.00 EGP (2.80/unit) -> ? strength differs SEPTRIN D.S 10 TABS. GLAXO SMITHKL... 28.00 EGP (2.80/unit) -> ? strength differs SEPTAZOLE 400/80MG 20*10 TABS. ALEXANDRIA 340.00 EGP (34.00/unit) -> ? strength differs SUTRIM 400/80MG 20*10 TAB. MEMPHIS 340.00 EGP (34.00/unit) -> ? strength differs CO-TRIMOXAZOLE 200/40MG SUSP. 120ML MUP 6.00 EGP -> ? strength differs, ? different route - not oral solid SUTRIM 200/40MG SUSP. 100ML MEMPHIS 18.50 EGP -> ? strength differs, ? different route - not oral solid 5. CIPROFLOXACIN [2nd line] Adult 250-500 mg BID x 3 days Peds Contraindicated in children due to joint toxicity AWaRe WATCH group - carries resistance cost. Egyptian EML 2025. Source IDSA/ESCMID Cystitis 2011 Why Held at second line for uncomplicated cystitis, reserved for complicated cases or treatment failure, and subject to the Egyptian Drug Authority's fluoroquinolone safety restrictions. The cited disease article gives no quinolone-specific threshold - only a general rule for E. coli, to switch antibiotic once local resistance passes 50%. No Egyptian quinolone resistance figure appears in the cited sources. Caution Reserve fluoroquinolones for complicated cases or failure. Avoid with antacids or iron supplements. There are tendonitis and QT prolongation risks. Egypt QUINOLOROX 500MG 10 F.C. TAB. EPCI > ROXXEN 10.00 EGP (1.00/unit) ECACIPROFLOX 500 MG 20 F.C. TABS. FUTURE PHARMACEUTICAL INDU... 27.00 EGP (1.35/unit) ELMODOXACIN 500MG 10 F.C.TAB. EGPI > SEA PHARM 20.00 EGP (2.00/unit) CIPROQUIN 500MG 10 F.C. TAB. UNIPHARMA 50.00 EGP (5.00/unit) CIPROFLOXACIN-ORGANO 500 MG 10 F.C.TABS. ORGANOPHARMA > ORGANO 63.00 EGP (6.30/unit) CIPROFAR 500MG 10 F.C.TAB. PHARCO 69.00 EGP (6.90/unit) CIPROMEGA XL 500MG 10 EXT. REL. F.C.TABS. MASH PREMIERE 48.00 EGP HEROXACIN 500MG 10 SCORED F.C. TAB. EGPI > HERO PHARM 69.00 EGP 6. AMOXICILLIN + CLAVULANIC ACID [2nd line] Adult 500/125 mg twice daily x 5-7 days Peds 25-45 mg/kg/day [child max 1750 mg] (Of the amoxicillin component, divided twice daily using a 7:1 suspension (200/28.5 or 400/57 mg per 5 mL); maximum 1750 mg/day. Do not give the 250 mg film-coated tablet to a child under 40 kg - the clavulanate share is too high.) 3kg -> 75-135 mg/day 4kg -> 100-180 mg/day 5kg -> 125-225 mg/day 6kg -> 150-270 mg/day 7kg -> 175-315 mg/day 8kg -> 200-360 mg/day 9kg -> 225-405 mg/day 10kg -> 250-450 mg/day 11kg -> 275-495 mg/day 12kg -> 300-540 mg/day 13kg -> 325-585 mg/day 14kg -> 350-630 mg/day 15kg -> 375-675 mg/day 16kg -> 400-720 mg/day 17kg -> 425-765 mg/day 18kg -> 450-810 mg/day 19kg -> 475-855 mg/day 20kg -> 500-900 mg/day 21kg -> 525-945 mg/day 22kg -> 550-990 mg/day 23kg -> 575-1035 mg/day 24kg -> 600-1080 mg/day 25kg -> 625-1125 mg/day 26kg -> 650-1170 mg/day 27kg -> 675-1215 mg/day 28kg -> 700-1260 mg/day 29kg -> 725-1305 mg/day 30kg -> 750-1350 mg/day 31kg -> 775-1395 mg/day 32kg -> 800-1440 mg/day 33kg -> 825-1485 mg/day 34kg -> 850-1530 mg/day 35kg -> 875-1575 mg/day 36kg -> 900-1620 mg/day 37kg -> 925-1665 mg/day 38kg -> 950-1710 mg/day 39kg -> 975-1750 mg/day (upper capped) 40kg -> 1000-1750 mg/day (upper capped) 41kg -> 1025-1750 mg/day (upper capped) 42kg -> 1050-1750 mg/day (upper capped) 43kg -> 1075-1750 mg/day (upper capped) 44kg -> 1100-1750 mg/day (upper capped) 45kg -> 1125-1750 mg/day (upper capped) 46kg -> 1150-1750 mg/day (upper capped) 47kg -> 1175-1750 mg/day (upper capped) 48kg -> 1200-1750 mg/day (upper capped) 49kg -> 1225-1750 mg/day (upper capped) 50kg -> 1250-1750 mg/day (upper capped) Choice Sourced preference. The Egyptian EML 2025 names amoxicillin + clavulanic acid a first- choice antibiotic here, while co-trimoxazole and ciprofloxacin are both demoted for local resistance above 40%. Source Egyptian National Drug Formulary - Antimicrobial 2023 (amoxicillin and clavulanate monograph) Why The Egyptian EML 2025 names amoxicillin + clavulanic acid a first-choice antibiotic for lower urinary tract infections, alongside nitrofurantoin and co-trimoxazole. It is the practical first-line in pregnancy, where the formulary contraindicates nitrofurantoin in a pregnancy at term - 38 to 42 weeks - and during labour and delivery, and says of co- trimoxazole that some guidelines recommend keeping away from it in the third trimester. The formulary's own cystitis dose is 500 mg twice daily. Caution An Access-group antibiotic and an Egyptian EML first choice for lower UTI - it does not need justifying the way a quinolone does. Avoid in penicillin allergy; avoid if there has been previous cholestatic jaundice with this drug. Diarrhoea is commoner than with amoxicillin alone; take with food. Reduce the dose if creatinine clearance is below 30 mL/min. Egypt AUJED 625 MG 12 F.C. TAB. SIGMA TEC > J... 19.20 EGP (1.60/unit) E-MOXCLAV 625MG 10 TAB. EIPICO 30.00 EGP (3.00/unit) DEXICLAVE 625 MG 12 F.C. TABS. RAMEDA > NOVE... 37.50 EGP (3.12/unit) MAGNABIOTIC 625MG 8 TAB. SEDICO 37.00 EGP (4.62/unit) CLAVIMOX 625 MG 12 F.C.TABS. PHARCO 107.00 EGP (8.92/unit) CURAM 625MG 12 F.C.TAB. SANDOZ > NOVA... 108.00 EGP (9.00/unit) AUGMENTIN 625 MG 10 F.C.TABS. MUP > SMITHKL... 117.00 EGP (11.70/unit) CLAVOCILLIN 625 MG 10 DISPERSIBLE TABS. RAMEDA > ORGANOPHARMA 31.50 EGP LARYNCLAVE 125/31 PD. FOR ORAL SUSP. 70ML MISR > AL ROWAD PHARMACEUTICAL... 8.00 EGP -> ? strength differs, ? different route - not oral solid MEGACLAVOX 156MG/5ML PD. FOR SUSP. 60 ML CID 8.00 EGP -> ? strength differs, ? different route - not oral solid MAIN TREATMENT 7. REFERRAL & SAFETY-NETTING (NO DRUG THERAPY) [1st line] Adult Source Uncomplicated Urinary Tract Infections - disease-level clinical article (uti- uncomplicated-clinical.txt) Why Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen. Caution RED FLAG - Fever, chills, nausea, vomiting, or back or flank pain indicates pyelonephritis or upper tract involvement. ORAL OPTION WHERE RESISTANCE RULES THE USUAL AGENTS OUT - NO EGYPTIAN PRODUCT REGISTERED 8. PIVMECILLINAM [3rd line] Adult A three-day course with a double first dose. SmPC verbatim: "Acute uncomplicated cystitis: 72 hour course of 2 tablets immediately followed by 1 tablet 3 times daily to a total of 10 tablets." On 200 mg tablets that is 400 mg once, then 200 mg three times a day. For a bacteriuria that keeps returning the SmPC gives a heavier regimen: "Chronic or recurrent bacteriuria: 2 tablets three to four times daily." - Three days. SmPC verbatim: a "72 hour course" totalling ten tablets. Peds The SmPC doses children by weight but this is not a first move in a child. Verbatim: "Children weighing more than 40 kg" take the adult 72-hour course; "Children weighing less than 40 kg Urinary tract infections: 20-40 mg/kg body weight, daily, in 3 to 4 divided doses." No worked milligram table is printed here on purpose - a urinary infection in a small child needs the cause looked for, not a second-choice antibiotic reached for. Source Selexid 200 mg Film-coated Tablets (pivmecillinam hydrochloride) SmPC sections 4.1, 4.2, 4.3, 4.4 and 4.6 (eMC product 3799) Why The disease article names the drug twice and says where it sits, verbatim: "Pivmecilinam may be considered when other agents cannot be used due to resistance or other factors, although it is not typically preferred for long-term use." and "Pivmecillinam is better tolerated than nitrofurantoin, and it effectively covers ESBL-producing and multiple drug-resistant strains of E coli, P mirabilis, and S saprophyticus." The SmPC's indication section names urinary tract infections and its posology names the syndrome, verbatim: "Acute uncomplicated cystitis". ESBL-producing E coli is common in Cairo and the card's existing options narrow quickly against it. Egypt registers no pivmecillinam product, so no brand and no price can be shown. Caution Contraindicated in more than the obvious group. SmPC verbatim: "Hypersensitivity to penicillins and/or cephalosporins. Any conditions resulting in impaired transit through the oesophagus." and "Genetic metabolism anomalies known to be leading to severe carnitine deficiency, such as carnitine transporter defect, methylmalonic aciduria or propionic acidaemia." Take it upright, with fluid and food. SmPC verbatim: "The tablets must be taken with at least half a glass of fluid, and preferably taken with or immediately after a meal." The oesophageal contraindication above is the reason this instruction carries weight. Severe skin reactions end the course. SmPC verbatim: "Severe cutaneous adverse reactions (SCAR) such as acute generalized exanthematous pustulosis (AGEP), drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) have been reported in relation to beta-lactam treatment, including Selexid. When SCAR is suspected, Selexid should be discontinued immediately". It depletes carnitine, and valproate makes that worse. SmPC verbatim: "Selexid tablets should be used with caution for long-term or frequently-repeated treatment, due to the possibility of carnitine depletion. Symptoms of carnitine depletion include muscle aches, fatigue, and confusion." and "Concurrent treatment with valproic acid, valproate or other medication liberating pivalic acid should be avoided due to increased risk of carnitine depletion." Caution in porphyria. SmPC verbatim: "Selexid tablets should be used with caution in patients with porphyria since pivmecillinam has been associated with acute attacks of porphyria." It does not cover the gram-positive urinary organisms. The disease article does not recommend it against Pseudomonas, Acinetobacter or Enterococcus, nor against the other gram-positive urinary pathogens. A culture growing enterococcus is a reason to change, not to continue. Watch for antibiotic-associated colitis. SmPC verbatim: "Pseudomembranous colitis caused by Clostridium difficile may occur. If diarrhoea occurs after use, the possibility of pseudomembranous colitis should be considered". Egypt no Egyptian brand matched - prescribe by generic name PAIN - give alongside 9. IBUPROFEN [add-on - not a substitute] Adult 400 mg three times daily with or after food, maximum 1200 mg in 24 hours x up to 3 days for the dysuria Peds Uncomplicated cystitis in this entry is an adult presentation. A child with a urinary infection needs the paediatric UTI pathway, not this row. Source Ibuprofen 100 mg/5 ml SmPC section 4.2 (eMC product 4560) Why The EAU urological infections guideline gives a strong recommendation to offer non- antibiotic therapy as an alternative in non-geriatric patients with uncomplicated cystitis, and names ibuprofen and diclofenac as the NSAIDs shown to reduce antibiotic use. The guideline states no dose, so the dose here is the drug label's. Caution EAU frames the NSAID as an alternative to an antibiotic in a well non-elderly woman, not as an add-on. Symptom relief is less complete than with an antibiotic. EAU says there is no evidence for NSAID symptomatic treatment in geriatric patients and that NSAIDs are potentially inappropriate in that age group. Avoid in asthma, active peptic ulcer, and in renal impairment - which also means: not if you suspect this is pyelonephritis rather than cystitis. Contraindicated in the third trimester of pregnancy. Egypt DAJUANOFEN 400 MG 20 F.C. TABS. COPAD PHARMA 5.00 EGP (0.25/unit) FLABU 400MG 10 F.C.TAB. DELTA PHARMA 3.75 EGP (0.38/unit) NOVA-PROFEN 400MG 30 F.C. TABLETS SANOFI 12.75 EGP (0.42/unit) IBUPROFEN 400 MG 10 TAB. SEDICO 6.00 EGP (0.60/unit) MAFO 400 MG 30 F.C.TABS EIPICO 42.00 EGP (1.40/unit) BRUFEN 400 MG 30 TABS. KAHIRA > ABBO... 78.00 EGP (2.60/unit) PROFUSOL 400MG 20 S.G CAPS. EUROPEAN EGYP... 31.00 EGP ANALGIPROF 400 MG 25 SACHETS EVA PHARMA 37.50 EGP NOVA-PROFEN 100MG/5ML ORAL SUSP. 100ML SANOFI 2.25 EGP -> ? strength differs, ? different route - not oral solid BRUFEMOL-N SUSP. 60 ML ARAB DRUG COM... 4.50 EGP -> ? strength differs, ? different route - not oral solid Prices are indicative (dataset snapshot 2026-06); verify with the pharmacy. ``` --- Dawaa Reference is a reference for prescribers, not a medical device, and does not replace clinical judgement. [Privacy policy](/privacy)