{
  "schema_version": 1,
  "kind": "condition",
  "id": "vitamin-d-deficiency",
  "name": "Vitamin D Deficiency (Nutritional)",
  "category": "chronic",
  "sources": "NICE Clinical Knowledge Summaries (CKS) Vitamin D deficiency / Royal Osteoporosis Society (ROS) Vitamin D Guidelines 2020 & Invita D3 50,000 IU Capsules SmPC (https://www.medicines.org.uk/emc/product/10188/smpc) · NICE Guideline PH56: Vitamin D 2014 · One-Alpha (alfacalcidol) 1 microgram soft capsules SmPC sections 4.1-4.4 (eMC product 5516)",
  "review_status": "reviewed",
  "verified_against": "DailyMed DRISDOL (ergocalciferol) 50,000 IU capsule label, SetID acb61678-d23d-405d-8c14-1a16cfd3a776 · Vitamin D Deficiency - StatPearls - NCBI Bookshelf (NBK532266) · Vitamin D Deficiency - disease-level clinical article (vitamin-d-deficiency-clinical.txt)",
  "verified_date": "2026-08",
  "treatments": [
    {
      "id": 1889,
      "generic": "Cholecalciferol",
      "line": 1,
      "is_adjunct": false,
      "form": "oral.solid",
      "strength_mg": 1.25,
      "adult_dose": "Loading: 50,000 IU (1.25 mg) once weekly for 8 weeks. Maintenance after loading: 1,000-2,000 IU daily. An equivalent loading option is 6,000 IU daily for 8 weeks. Always prescribe in IU - do not write \"one tablet\", because Egyptian products range from 1,000 IU tablets to 50,000 IU capsules.",
      "adult_duration": null,
      "dose_source": "Regimen per Vitamin D Deficiency - StatPearls - NCBI Bookshelf (NBK532266), stated here in our own words; strength conversion and the toxicity warning from DailyMed DRISDOL (ergocalciferol) 50,000 IU capsule label, SetID acb61678-d23d-405d-8c14-1a16cfd3a776",
      "rationale": "Vitamin D3 replacement that restores vitamin D stores needed for intestinal calcium absorption and bone mineralisation; corrects nutritional vitamin D deficiency and helps prevent the metabolic bone disease that results from chronic deficiency.",
      "cautions": [
        "Take with a fat-containing meal to maximize gastrointestinal absorption.",
        "The margin between an effective and a toxic dose is narrow - the US label states: \"THE RANGE BETWEEN THERAPEUTIC AND TOXIC DOSES IS NARROW.\" (DailyMed DRISDOL (ergocalciferol) 50,000 IU capsule label, SetID acb61678-d23d-405d-8c14-1a16cfd3a776)",
        "Monitor serum calcium; avoid in hypercalcemia or granulomatous conditions (sarcoidosis).",
        "50,000 IU corresponds to 1.25 mg elemental cholecalciferol.",
        "Alfacalcidol belongs to renal osteodystrophy, hypoparathyroidism and the other states where 1-alpha hydroxylation is actually impaired. If that entry is wanted, it is a separate condition, not a line on this one."
      ],
      "peds_mgkg_low": null,
      "peds_mgkg_high": null,
      "peds_max_mg": null,
      "peds_basis": null,
      "peds_unit": null,
      "peds_note": "Children: 2,000 IU daily, or 50,000 IU once weekly for 6 weeks, then 1,000 IU daily as maintenance. Check the product strength before prescribing.",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": null,
      "brands": [
        {
          "trade_name": "DAVALINDI 1000 I.U. 100 TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "MUP",
          "price_egp": 77.0,
          "pack_count": 100,
          "unit_price": 0.77,
          "strength_mg": null,
          "exact_strength": false,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "D3 PANAX BUTRITION 5000 I.U. 30 CAPS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "PANAX PHARMA",
          "price_egp": 32.0,
          "pack_count": 30,
          "unit_price": 1.07,
          "strength_mg": null,
          "exact_strength": false,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "D3 5000 I.U. 30 TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "NAPCO",
          "price_egp": 38.0,
          "pack_count": 30,
          "unit_price": 1.27,
          "strength_mg": null,
          "exact_strength": false,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "HINDA D3 - 30 TABS.",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "HP PHARMA",
          "price_egp": 92.0,
          "pack_count": 30,
          "unit_price": 3.07,
          "strength_mg": null,
          "exact_strength": false,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "AVALON VITAMIN D 30 CAPSULES",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "ORGANIX COMPANY > EL-NOR PHARMACECEUTICAL COMPANY",
          "price_egp": 170.0,
          "pack_count": 30,
          "unit_price": 5.67,
          "strength_mg": null,
          "exact_strength": false,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "DETHREA D 10 ML",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "COPAD > VIGOR MED PHARAMA",
          "price_egp": 45.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": null,
          "exact_strength": false,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "VITAMIN D3 2000 I.U. 120 SOFTGELS (NOW)",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "NOW FOODS > SOFICOPHARM",
          "price_egp": 999.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": null,
          "exact_strength": false,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "VITAMIN D3 10.000 I.U. 120 SOFTGELS (NOW)",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "NOW FOODS > SOFICOPHARM",
          "price_egp": 1300.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": null,
          "exact_strength": false,
          "exact_form": true,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "UR-D 200 I.U./ML ORAL DROPS 25 ML",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "HI-PHARM",
          "price_egp": 21.6,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": null,
          "exact_strength": false,
          "exact_form": false,
          "discontinued": false,
          "also_contains": null
        },
        {
          "trade_name": "VIDROP 2800 I.U./ML ORAL DROPS 15 ML",
          "scientific_name": null,
          "normalized_ingredient": null,
          "manufacturer": "MUP",
          "price_egp": 26.0,
          "pack_count": null,
          "unit_price": null,
          "strength_mg": null,
          "exact_strength": false,
          "exact_form": false,
          "discontinued": false,
          "also_contains": null
        }
      ],
      "condition_id": "vitamin-d-deficiency"
    },
    {
      "id": 1890,
      "generic": "Referral & safety-netting (no drug therapy)",
      "line": 1,
      "is_adjunct": false,
      "form": null,
      "strength_mg": null,
      "adult_dose": null,
      "adult_duration": null,
      "dose_source": "Vitamin D Deficiency - disease-level clinical article (vitamin-d-deficiency-clinical.txt)",
      "rationale": "Carries the referral criteria and warning signs for this condition, which apply whichever treatment is chosen.",
      "cautions": [
        "RED FLAG - The features of vitamin D toxicity and hypercalcemia are confusion, anorexia, vomiting, polyuria, polydipsia, muscle weakness, and nephrocalcinosis."
      ],
      "peds_mgkg_low": null,
      "peds_mgkg_high": null,
      "peds_max_mg": null,
      "peds_basis": null,
      "peds_unit": null,
      "peds_note": null,
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": null,
      "brands": [],
      "condition_id": "vitamin-d-deficiency"
    },
    {
      "id": 1891,
      "generic": "Calcidiol",
      "line": 2,
      "is_adjunct": false,
      "form": "oral.solid",
      "strength_mg": null,
      "adult_dose": "30 to 200 μg daily",
      "adult_duration": null,
      "dose_source": "Vitamin D Deficiency (Nutritional) - disease-level clinical article (vitamin-d-deficiency-clinical.txt)",
      "rationale": "Vitamin D metabolite for patients with severe hepatic dysfunction that does not require 25-hydroxylase activation in the liver.",
      "cautions": [
        "Serum calcium levels should be monitored to prevent hypercalcemia."
      ],
      "peds_mgkg_low": null,
      "peds_mgkg_high": null,
      "peds_max_mg": null,
      "peds_basis": null,
      "peds_unit": null,
      "peds_note": "No paediatric dose is stated in the sources held for this drug.",
      "peds_min_weight_kg": null,
      "peds_max_weight_kg": null,
      "peds_age_min_months": null,
      "peds_age_max_months": null,
      "peds_age_bands": null,
      "peds_doses": null,
      "brands": [],
      "condition_id": "vitamin-d-deficiency"
    }
  ]
}