{
  "schema_version": 1,
  "kind": "drug_profile",
  "generic": "atenolol",
  "review_status": "reviewed",
  "origin": "openfda",
  "sections": {
    "adult": [
      {
        "text": "Hypertension The initial dose of atenolol tablets USP is 50 mg given as one tablet a day either alone or added to diuretic therapy.",
        "source": "US FDA label for atenolol (Atenolol), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/atenolol.json",
        "verbatim": true
      },
      {
        "text": "If an optimal response is not achieved, the dosage should be increased to atenolol tablets USP 100 mg given as one tablet a day.",
        "source": "US FDA label for atenolol (Atenolol), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/atenolol.json",
        "verbatim": true
      },
      {
        "text": "Increasing the dosage beyond 100 mg a day is unlikely to produce any further benefit.",
        "source": "US FDA label for atenolol (Atenolol), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/atenolol.json",
        "verbatim": true
      }
    ],
    "child": [
      {
        "text": "Safety and effectiveness in pediatric patients have not been established.",
        "source": "US FDA label for atenolol (Atenolol), section 'pediatric use', retrieved 2026-08-29",
        "cached_file": "labels/atenolol.json",
        "verbatim": true
      }
    ],
    "renal": [
      {
        "text": "Elderly Patients or Patients With Renal Impairment Atenolol tablets USP are excreted by the kidneys; consequently dosage should be adjusted in cases of severe impairment of renal function.",
        "source": "US FDA label for atenolol (Atenolol), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/atenolol.json",
        "verbatim": true
      },
      {
        "text": "No significant accumulation of atenolol tablets USP occurs until creatinine clearance falls below 35 mL/min/1.73 m 2 .",
        "source": "US FDA label for atenolol (Atenolol), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/atenolol.json",
        "verbatim": true
      },
      {
        "text": "Accumulation of atenolol and prolongation of its half-life were studied in subjects with creatinine clearance between 5 and 105 mL/min.",
        "source": "US FDA label for atenolol (Atenolol), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/atenolol.json",
        "verbatim": true
      }
    ],
    "hepatic": [
      {
        "text": "No liver-impairment dose in this label. Not a statement that none is needed.",
        "source": "Read and found silent: the US FDA label for atenolol (Atenolol), retrieved 2026-08-29",
        "cached_file": "labels/atenolol.json",
        "verbatim": false
      }
    ],
    "pregnancy": [
      {
        "text": "Usage in Pregnancy Teratogenic Effects Pregnancy Category D See WARNINGS , Pregnancy and Fetal Injury .",
        "source": "US FDA label for atenolol (Atenolol), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/atenolol.json",
        "verbatim": true
      }
    ],
    "lactation": [
      {
        "text": "Atenolol is excreted in human breast milk at a ratio of 1.5 to 6.8 when compared to the concentration in plasma.",
        "source": "US FDA label for atenolol (Atenolol), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/atenolol.json",
        "verbatim": true
      },
      {
        "text": "Caution should be exercised when atenolol is administered to a nursing woman.",
        "source": "US FDA label for atenolol (Atenolol), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/atenolol.json",
        "verbatim": true
      },
      {
        "text": "Clinically significant bradycardia has been reported in breastfed infants.",
        "source": "US FDA label for atenolol (Atenolol), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/atenolol.json",
        "verbatim": true
      }
    ]
  },
  "verdicts": {
    "lactation": {
      "level": "caution",
      "line": "The label allows it only when the benefit is judged to outweigh the risk. Read the quote below.",
      "set_by": "Set from the label's own words, not from a reading of them: 'Caution should be exercised when atenolol is administered to a nursing'."
    }
  }
}