Benzathine Penicillin G

DRUG INFORMATION

  ADULT
    - Syphilis Primary, secondary, and latent—2,400,000 units (1 dose).
      Source: US FDA label for penicillin g benzathine (BICILLIN L-A), section 'dosage
      and administration', retrieved 2026-08-29
    - Late (tertiary and neurosyphilis)—2,400,000 units at 7-day intervals for three
      doses.
      Source: US FDA label for penicillin g benzathine (BICILLIN L-A), section 'dosage
      and administration', retrieved 2026-08-29
    - Following an acute attack, penicillin G benzathine (parenteral) may be given in
      doses of 1,200,000 units once a month or 600,000 units every 2 weeks.
      Source: US FDA label for penicillin g benzathine (BICILLIN L-A), section 'dosage
      and administration', retrieved 2026-08-29

  CHILD
    - Streptococcal (Group A) Upper Respiratory Infections (for example, pharyngitis)
      Adults—a single injection of 1,200,000 units; older pediatric patients—a single
      injection of 900,000 units; infants and pediatric patients under 60 lbs.—300,000
      to 600,000 units. Syphilis Primary, secondary, and latent—2,400,000 units (1
      dose). Late (tertiary and neurosyphilis)—2,400,000 units at 7-day intervals for
      three doses.
      Source: US FDA label for penicillin g benzathine (BICILLIN L-A), section 'dosage
      and administration', retrieved 2026-08-29

  RENAL IMPAIRMENT
    - No kidney-impairment dose in this label. Not a statement that none is needed.
      Source: Read and found silent: the US FDA label for penicillin g benzathine
      (BICILLIN L-A), retrieved 2026-08-29

  HEPATIC IMPAIRMENT
    - No liver-impairment dose in this label. Not a statement that none is needed.
      Source: Read and found silent: the US FDA label for penicillin g benzathine
      (BICILLIN L-A), retrieved 2026-08-29

  PREGNANCY
    - Teratogenic effects Pregnancy Reproduction studies performed in the mouse, rat,
      and rabbit have revealed no evidence of impaired fertility or harm to the fetus
      due to penicillin G.
      Source: US FDA label for penicillin g benzathine (BICILLIN L-A), section
      'pregnancy', retrieved 2026-08-29
    - Human experience with the penicillins during pregnancy has not shown any positive
      evidence of adverse effects on the fetus.
      Source: US FDA label for penicillin g benzathine (BICILLIN L-A), section
      'pregnancy', retrieved 2026-08-29
    - There are, however, no adequate and well-controlled studies in pregnant women
      showing conclusively that harmful effects of these drugs on the fetus can be
      excluded.
      Source: US FDA label for penicillin g benzathine (BICILLIN L-A), section
      'pregnancy', retrieved 2026-08-29

  BREASTFEEDING   [ CAUTION ]
    The label allows it only when the benefit is judged to outweigh the risk. Read the
      quote below.
    - Soluble penicillin G (the hydrolysate of penicillin G benzathine) is excreted in
      breast milk.
      Source: US FDA label for penicillin g benzathine (BICILLIN L-A), section 'nursing
      mothers', retrieved 2026-08-29
    - Caution should be exercised when penicillin G benzathine is administered to a
      nursing woman.
      Source: US FDA label for penicillin g benzathine (BICILLIN L-A), section 'nursing
      mothers', retrieved 2026-08-29