{
  "schema_version": 1,
  "kind": "drug_profile",
  "generic": "benzathine penicillin g",
  "review_status": "reviewed",
  "origin": "openfda",
  "sections": {
    "adult": [
      {
        "text": "Syphilis Primary, secondary, and latent—2,400,000 units (1 dose).",
        "source": "US FDA label for penicillin g benzathine (BICILLIN L-A), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/benzathine-penicillin-g.json",
        "verbatim": true
      },
      {
        "text": "Late (tertiary and neurosyphilis)—2,400,000 units at 7-day intervals for three doses.",
        "source": "US FDA label for penicillin g benzathine (BICILLIN L-A), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/benzathine-penicillin-g.json",
        "verbatim": true
      },
      {
        "text": "Following an acute attack, penicillin G benzathine (parenteral) may be given in doses of 1,200,000 units once a month or 600,000 units every 2 weeks.",
        "source": "US FDA label for penicillin g benzathine (BICILLIN L-A), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/benzathine-penicillin-g.json",
        "verbatim": true
      }
    ],
    "child": [
      {
        "text": "Streptococcal (Group A) Upper Respiratory Infections (for example, pharyngitis) Adults—a single injection of 1,200,000 units; older pediatric patients—a single injection of 900,000 units; infants and pediatric patients under 60 lbs.—300,000 to 600,000 units. Syphilis Primary, secondary, and latent—2,400,000 units (1 dose). Late (tertiary and neurosyphilis)—2,400,000 units at 7-day intervals for three doses.",
        "source": "US FDA label for penicillin g benzathine (BICILLIN L-A), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/benzathine-penicillin-g.json",
        "verbatim": true
      }
    ],
    "renal": [
      {
        "text": "No kidney-impairment dose in this label. Not a statement that none is needed.",
        "source": "Read and found silent: the US FDA label for penicillin g benzathine (BICILLIN L-A), retrieved 2026-08-29",
        "cached_file": "labels/benzathine-penicillin-g.json",
        "verbatim": false
      }
    ],
    "hepatic": [
      {
        "text": "No liver-impairment dose in this label. Not a statement that none is needed.",
        "source": "Read and found silent: the US FDA label for penicillin g benzathine (BICILLIN L-A), retrieved 2026-08-29",
        "cached_file": "labels/benzathine-penicillin-g.json",
        "verbatim": false
      }
    ],
    "pregnancy": [
      {
        "text": "Teratogenic effects Pregnancy Reproduction studies performed in the mouse, rat, and rabbit have revealed no evidence of impaired fertility or harm to the fetus due to penicillin G.",
        "source": "US FDA label for penicillin g benzathine (BICILLIN L-A), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/benzathine-penicillin-g.json",
        "verbatim": true
      },
      {
        "text": "Human experience with the penicillins during pregnancy has not shown any positive evidence of adverse effects on the fetus.",
        "source": "US FDA label for penicillin g benzathine (BICILLIN L-A), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/benzathine-penicillin-g.json",
        "verbatim": true
      },
      {
        "text": "There are, however, no adequate and well-controlled studies in pregnant women showing conclusively that harmful effects of these drugs on the fetus can be excluded.",
        "source": "US FDA label for penicillin g benzathine (BICILLIN L-A), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/benzathine-penicillin-g.json",
        "verbatim": true
      }
    ],
    "lactation": [
      {
        "text": "Soluble penicillin G (the hydrolysate of penicillin G benzathine) is excreted in breast milk.",
        "source": "US FDA label for penicillin g benzathine (BICILLIN L-A), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/benzathine-penicillin-g.json",
        "verbatim": true
      },
      {
        "text": "Caution should be exercised when penicillin G benzathine is administered to a nursing woman.",
        "source": "US FDA label for penicillin g benzathine (BICILLIN L-A), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/benzathine-penicillin-g.json",
        "verbatim": true
      }
    ]
  },
  "verdicts": {
    "lactation": {
      "level": "caution",
      "line": "The label allows it only when the benefit is judged to outweigh the risk. Read the quote below.",
      "set_by": "Set from the label's own words, not from a reading of them: 'Caution should be exercised when penicillin G benzathine is administered to a nursing'."
    }
  }
}