{
  "schema_version": 1,
  "kind": "drug_profile",
  "generic": "carbamazepine",
  "review_status": "reviewed",
  "origin": "openfda",
  "sections": {
    "adult": [
      {
        "text": "Epilepsy ( SEE INDICATIONS AND USAGE ) Adults and children over 12 years of age-Initial: Either 200 mg twice a day for tablets and extended-release tablets, or 1 teaspoon four times a day for suspension (400 mg/day).",
        "source": "US FDA label for carbamazepine (Carbamazepine), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/carbamazepine.json",
        "verbatim": true
      },
      {
        "text": "Increase at weekly intervals by adding up to 200 mg/day using a twice a day regimen of carbamazepine extended-release tablets or a three times a day or four times a day regimen of the other formulations until the optimal response is obtained.",
        "source": "US FDA label for carbamazepine (Carbamazepine), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/carbamazepine.json",
        "verbatim": true
      },
      {
        "text": "Doses up to 1600 mg daily have been used in adults in rare instances.",
        "source": "US FDA label for carbamazepine (Carbamazepine), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/carbamazepine.json",
        "verbatim": true
      }
    ],
    "child": [
      {
        "text": "(SEE TABLE BELOW) Carbamazepine suspension in combination with liquid chlorpromazine or thioridazine results in precipitate formation, and, in the case of chlorpromazine, there has been a report of a patient passing an orange rubbery precipitate in the stool following coadministration of the two drugs (see PRECAUTIONS, Drug Interactions ).",
        "source": "US FDA label for carbamazepine (Carbamazepine), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/carbamazepine.json",
        "verbatim": true
      },
      {
        "text": "Epilepsy ( SEE INDICATIONS AND USAGE ) Adults and children over 12 years of age-Initial: Either 200 mg twice a day for tablets and extended-release tablets, or 1 teaspoon four times a day for suspension (400 mg/day).",
        "source": "US FDA label for carbamazepine (Carbamazepine), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/carbamazepine.json",
        "verbatim": true
      },
      {
        "text": "Dosage generally should not exceed 1000 mg daily in children 12 years to 15 years of age, and 1200 mg daily in patients above 15 years of age.",
        "source": "US FDA label for carbamazepine (Carbamazepine), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/carbamazepine.json",
        "verbatim": true
      }
    ],
    "renal": [
      {
        "text": "No kidney-impairment dose in this label. Not a statement that none is needed.",
        "source": "Read and found silent: the US FDA label for carbamazepine (Carbamazepine), retrieved 2026-08-29",
        "cached_file": "labels/carbamazepine.json",
        "verbatim": false
      }
    ],
    "hepatic": [
      {
        "text": "No liver-impairment dose in this label. Not a statement that none is needed.",
        "source": "Read and found silent: the US FDA label for carbamazepine (Carbamazepine), retrieved 2026-08-29",
        "cached_file": "labels/carbamazepine.json",
        "verbatim": false
      }
    ],
    "pregnancy": [
      {
        "text": "Nothing on pregnancy in this label. Treat as unknown, not as safe.",
        "source": "Read and found silent: the US FDA label for carbamazepine (Carbamazepine), retrieved 2026-08-29",
        "cached_file": "labels/carbamazepine.json",
        "verbatim": false
      }
    ],
    "lactation": [
      {
        "text": "Carbamazepine and its epoxide metabolite are transferred to breast milk.",
        "source": "US FDA label for carbamazepine (Carbamazepine), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/carbamazepine.json",
        "verbatim": true
      },
      {
        "text": "The ratio of the concentration in breast milk to that in maternal plasma is about 0.4 for carbamazepine and about 0.5 for the epoxide.",
        "source": "US FDA label for carbamazepine (Carbamazepine), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/carbamazepine.json",
        "verbatim": true
      },
      {
        "text": "The estimated doses given to the newborn during breastfeeding are in the range of 2 mg to 5 mg daily for carbamazepine and 1 mg to 2 mg daily for the epoxide.",
        "source": "US FDA label for carbamazepine (Carbamazepine), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/carbamazepine.json",
        "verbatim": true
      }
    ]
  }
}