Estradiol Valerate

DRUG INFORMATION

  ADULT
    - Since the 40 mg potency provides a high concentration in a small volume,
      particular care should be observed to administer the full dose.
      Source: US FDA label for estradiol valerate (Estradiol valerate), section 'dosage
      and administration', retrieved 2026-08-29
    - The usual dosage is 10 to 20 mg Estradiol valerate injection, USP every four
      weeks.
      Source: US FDA label for estradiol valerate (Estradiol valerate), section 'dosage
      and administration', retrieved 2026-08-29
    - The usual dosage is 30 mg or more administered every one or two weeks.
      Source: US FDA label for estradiol valerate (Estradiol valerate), section 'dosage
      and administration', retrieved 2026-08-29

  CHILD
    - H. Pediatric Use Safety and effectiveness in pediatric patients have not been
      established. Large and repeated doses of estrogen over an extended period of time
      may accelerate epiphyseal closure. Therefore, periodic monitoring of bone
      maturation and effects on epiphyseal centers is recommended in patients in whom
      bone growth is not complete.
      Source: US FDA label for estradiol valerate (Estradiol valerate), section
      'pediatric use', retrieved 2026-08-29

  RENAL IMPAIRMENT
    - No kidney-impairment dose in this label. Not a statement that none is needed.
      Source: Read and found silent: the US FDA label for estradiol valerate (Estradiol
      valerate), retrieved 2026-08-29

  HEPATIC IMPAIRMENT
    - No liver-impairment dose in this label. Not a statement that none is needed.
      Source: Read and found silent: the US FDA label for estradiol valerate (Estradiol
      valerate), retrieved 2026-08-29

  PREGNANCY   [ AVOID ]
    The label says not to use it. Read the quote below before deciding.
    - Pregnancy Estradiol valerate injection, USP should not be used during pregnancy.
      Source: US FDA label for estradiol valerate (Estradiol valerate), section
      'pregnancy', retrieved 2026-08-29

  BREASTFEEDING   [ CAUTION ]
    The label allows it only when the benefit is judged to outweigh the risk. Read the
      quote below.
    - Nursing Mothers Estrogen administration to nursing mothers has been shown to
      decrease the quantity and quality of the milk.
      Source: US FDA label for estradiol valerate (Estradiol valerate), section 'nursing
      mothers', retrieved 2026-08-29
    - Detectable amounts of estrogens have been identified in the milk of mothers
      receiving this drug.
      Source: US FDA label for estradiol valerate (Estradiol valerate), section 'nursing
      mothers', retrieved 2026-08-29
    - Caution should be exercised when Estradiol valerate injection, USP is administered
      to a nursing woman.
      Source: US FDA label for estradiol valerate (Estradiol valerate), section 'nursing
      mothers', retrieved 2026-08-29