{
  "schema_version": 1,
  "kind": "drug_profile",
  "generic": "gentamicin",
  "review_status": "reviewed",
  "origin": "openfda",
  "sections": {
    "adult": [
      {
        "text": "Patients with Normal Renal Function Adults: The recommended dosage of Gentamicin Sulfate in 0.9% Sodium Chloride Injection for patients with serious infections and normal renal function is 3 mg/kg/day administered in three equal doses every eight hours (Table 3).",
        "source": "This line points to a numbered table that this card does not show - read that table in the label before you dose. US FDA label for gentamicin (Gentamicin Sulfate in Sodium Chloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/gentamicin.json",
        "verbatim": true
      },
      {
        "text": "For patients with life-threatening infections, dosages up to 5 mg/kg/day may be administered in three or four equal doses.",
        "source": "US FDA label for gentamicin (Gentamicin Sulfate in Sodium Chloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/gentamicin.json",
        "verbatim": true
      },
      {
        "text": "The dosage should be reduced to 3 mg/kg/day as soon as clinically indicated (Table 3).",
        "source": "This line points to a numbered table that this card does not show - read that table in the label before you dose. US FDA label for gentamicin (Gentamicin Sulfate in Sodium Chloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/gentamicin.json",
        "verbatim": true
      }
    ],
    "child": [
      {
        "text": "In the neonate with suspected bacterial sepsis or staphylococcal pneumonia, a penicillin-type drug is also usually indicated as concomitant therapy with gentamicin. During or following gentamicin therapy, paresthesias, tetany, positive Chvostek and Trousseau signs and mental confusion have been described in patients with hypomagnesemia, hypocalcemia and hypokalemia. When this has occurred in infants, tetany and muscle weakness have been described.",
        "source": "US FDA label for gentamicin (Gentamicin Sulfate in Sodium Chloride), section 'pediatric use', retrieved 2026-08-29",
        "cached_file": "labels/gentamicin.json",
        "verbatim": true
      },
      {
        "text": "Gentamicin Sulfate in 0.9% Sodium Chloride Injection is for intravenous use only . The patient’s pretreatment body weight should be obtained for calculation of correct dosage. The dosage of aminoglycosides in obese patients should be based on an estimate of the lean body mass. It is desirable to limit the duration of treatment with aminoglycosides to short term.",
        "source": "US FDA label for gentamicin (Gentamicin Sulfate in Sodium Chloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/gentamicin.json",
        "verbatim": true
      },
      {
        "text": "Patients with Normal Renal Function Adults: The recommended dosage of Gentamicin Sulfate in 0.9% Sodium Chloride Injection for patients with serious infections and normal renal function is 3 mg/kg/day administered in three equal doses every eight hours (Table 3).",
        "source": "This line points to a numbered table that this card does not show - read that table in the label before you dose. US FDA label for gentamicin (Gentamicin Sulfate in Sodium Chloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/gentamicin.json",
        "verbatim": true
      }
    ],
    "renal": [
      {
        "text": "In patients with serious systemic infections and renal impairment, it may be desirable to administer the antibiotic more frequently but in reduced dosage.",
        "source": "US FDA label for gentamicin (Gentamicin Sulfate in Sodium Chloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/gentamicin.json",
        "verbatim": true
      },
      {
        "text": "It is important to recognize that deteriorating renal function may require a greater reduction of dosage than that specified in the above guidelines for patients with stable renal impairment.",
        "source": "US FDA label for gentamicin (Gentamicin Sulfate in Sodium Chloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/gentamicin.json",
        "verbatim": true
      },
      {
        "text": "The recommended dosage at the end of each dialysis period is 1 to 1.7 mg/kg depending upon the severity of infection.",
        "source": "US FDA label for gentamicin (Gentamicin Sulfate in Sodium Chloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/gentamicin.json",
        "verbatim": true
      }
    ],
    "hepatic": [
      {
        "text": "No liver-impairment dose in this label. Not a statement that none is needed.",
        "source": "Read and found silent: the US FDA label for gentamicin (Gentamicin Sulfate in Sodium Chloride), retrieved 2026-08-29",
        "cached_file": "labels/gentamicin.json",
        "verbatim": false
      }
    ],
    "pregnancy": [
      {
        "text": "Aminoglycosides can cause fetal harm when administered to a pregnant woman.",
        "source": "US FDA label for gentamicin (Gentamicin Sulfate in Sodium Chloride), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/gentamicin.json",
        "verbatim": true
      },
      {
        "text": "Aminoglycoside antibiotics cross the placenta and there have been several reports of total irreversible bilateral congenital deafness in children whose mothers received streptomycin during pregnancy.",
        "source": "US FDA label for gentamicin (Gentamicin Sulfate in Sodium Chloride), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/gentamicin.json",
        "verbatim": true
      },
      {
        "text": "Serious side effects to mother, fetus, or newborn have not been reported in the treatment of pregnant women with other aminoglycosides.",
        "source": "US FDA label for gentamicin (Gentamicin Sulfate in Sodium Chloride), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/gentamicin.json",
        "verbatim": true
      }
    ],
    "lactation": [
      {
        "text": "It is not known whether this drug is excreted in human milk.",
        "source": "US FDA label for gentamicin (Gentamicin Sulfate in Sodium Chloride), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/gentamicin.json",
        "verbatim": true
      },
      {
        "text": "Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from gentamicin, a decision should be made whether to discontinue the drug, taking into account the importance of the drug to the mother.",
        "source": "US FDA label for gentamicin (Gentamicin Sulfate in Sodium Chloride), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/gentamicin.json",
        "verbatim": true
      }
    ]
  }
}