# Perindopril

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DRUG INFORMATION

  ADULT
    - Hypertension The recommended initial dose is 4 mg once a day.
      Source: US FDA label for perindopril (Perindopril Erbumine), section 'dosage and
      administration', retrieved 2026-08-29
    - The dosage may be titrated upward until blood pressure, when measured just before
      the next dose, is controlled or to a maximum of 16 mg per day.
      Source: US FDA label for perindopril (Perindopril Erbumine), section 'dosage and
      administration', retrieved 2026-08-29
    - (2.1) Stable Coronary Artery Disease Perindopril erbumine tablets should be given
      at an initial dose of 4 mg once daily for 2 weeks, and then increased, as
      tolerated, to a maintenance dose of 8 mg once daily.
      Source: US FDA label for perindopril (Perindopril Erbumine), section 'dosage and
      administration', retrieved 2026-08-29

  CHILD
    - Neonates With a History of in utero Exposure to Perindopril Erbumine: If oliguria
      or hypotension occurs, direct attention toward support of blood pressure and renal
      perfusion. Exchange transfusions or dialysis may be required as a means of
      reversing hypotension and/or substituting for disordered renal function.
      Source: US FDA label for perindopril (Perindopril Erbumine), section 'pediatric
      use', retrieved 2026-08-29

  RENAL IMPAIRMENT
    - In elderly patients (greater than 70 years), perindopril erbumine tablets should
      be given as a 2 mg dose once daily in the first week, followed by 4 mg once daily
      in the second week and 8 mg once daily for maintenance dose if tolerated. 2.3 Dose
      Adjustment in Renal Impairment and Dialysis Perindoprilat elimination is decreased
      in renally impaired patients.
      Source: US FDA label for perindopril (Perindopril Erbumine), section 'dosage and
      administration', retrieved 2026-08-29
    - Perindopril erbumine tablets are not recommended in patients with creatinine
      clearance <30 mL/min.
      Source: US FDA label for perindopril (Perindopril Erbumine), section 'dosage and
      administration', retrieved 2026-08-29
    - During dialysis, perindopril is removed with the same clearance as in patients
      with normal renal function.
      Source: US FDA label for perindopril (Perindopril Erbumine), section 'dosage and
      administration', retrieved 2026-08-29

  HEPATIC IMPAIRMENT
    - Experience with perindopril erbumine in elderly patients at daily doses exceeding
      8 mg is limited. 8.6 Renal Impairment Dosage adjustment may be necessary in
      renally impaired patients [see Dosage and Administration (2.3) and Clinical
      Pharmacology (12.3) ] . 8.7 Hepatic Impairment The bioavailability of
      perindoprilat is increased in patients with impaired hepatic function [see
      Clinical Pharmacology (12.3) ] .
      Source: US FDA label for perindopril (Perindopril Erbumine), section 'use in
      specific populations', retrieved 2026-08-29

  PREGNANCY
    - Pregnancy Category D [see Boxed Warning and Warnings and Precautions (5.4) ] .
      Source: US FDA label for perindopril (Perindopril Erbumine), section 'pregnancy',
      retrieved 2026-08-29
    - Use of drugs that act on the renin-angiotensin system during the second and third
      trimesters of pregnancy reduces fetal renal function and increases fetal and
      neonatal morbidity and death.
      Source: US FDA label for perindopril (Perindopril Erbumine), section 'pregnancy',
      retrieved 2026-08-29
    - Resulting oligohydramnios can be associated with fetal lung hypoplasia and
      skeletal deformations.
      Source: US FDA label for perindopril (Perindopril Erbumine), section 'pregnancy',
      retrieved 2026-08-29

  BREASTFEEDING
    - Milk of lactating rats contained radioactivity following administration of 14
      C-perindopril.
      Source: US FDA label for perindopril (Perindopril Erbumine), section 'nursing
      mothers', retrieved 2026-08-29
    - It is not known whether perindopril is secreted in human milk.
      Source: US FDA label for perindopril (Perindopril Erbumine), section 'nursing
      mothers', retrieved 2026-08-29
    - Because many drugs are secreted in human milk, caution should be exercised when
      perindopril erbumine is given to nursing mothers.
      Source: US FDA label for perindopril (Perindopril Erbumine), section 'nursing
      mothers', retrieved 2026-08-29
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