{
  "schema_version": 1,
  "kind": "drug_profile",
  "generic": "pilocarpine",
  "review_status": "reviewed",
  "origin": "openfda",
  "sections": {
    "adult": [
      {
        "text": "Instill one drop in the eye(s) up to four times daily. (2) 2.1 Reduction of Elevated Intraocular Pressure (IOP) in Patients with Open-Angle Glaucoma or Ocular Hypertension One drop of pilocarpine hydrochloride ophthalmic solution 1%, 2% or 4% should be applied topically in the eye(s) up to four times daily. Pilocarpine-naïve patients should be started on the 1% concentration as higher concentrations are often not tolerated initially.",
        "source": "US FDA label for pilocarpine (Pilocarpine Hydrochloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/pilocarpine.json",
        "verbatim": true
      }
    ],
    "child": [
      {
        "text": "Safety and effectiveness of pilocarpine hydrochloride ophthalmic solution in pediatric patients have been established.",
        "source": "US FDA label for pilocarpine (Pilocarpine Hydrochloride), section 'pediatric use', retrieved 2026-08-29",
        "cached_file": "labels/pilocarpine.json",
        "verbatim": true
      },
      {
        "text": "Instill one drop in the eye(s) up to four times daily. (2) 2.1 Reduction of Elevated Intraocular Pressure (IOP) in Patients with Open-Angle Glaucoma or Ocular Hypertension One drop of pilocarpine hydrochloride ophthalmic solution 1%, 2% or 4% should be applied topically in the eye(s) up to four times daily. Pilocarpine-naïve patients should be started on the 1% concentration as higher concentrations are often not tolerated initially.",
        "source": "US FDA label for pilocarpine (Pilocarpine Hydrochloride), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/pilocarpine.json",
        "verbatim": true
      }
    ],
    "renal": [
      {
        "text": "No kidney-impairment dose in this label. Not a statement that none is needed.",
        "source": "Read and found silent: the US FDA label for pilocarpine (Pilocarpine Hydrochloride), retrieved 2026-08-29",
        "cached_file": "labels/pilocarpine.json",
        "verbatim": false
      }
    ],
    "hepatic": [
      {
        "text": "No liver-impairment dose in this label. Not a statement that none is needed.",
        "source": "Read and found silent: the US FDA label for pilocarpine (Pilocarpine Hydrochloride), retrieved 2026-08-29",
        "cached_file": "labels/pilocarpine.json",
        "verbatim": false
      }
    ],
    "pregnancy": [
      {
        "text": "Animal reproduction studies have not been conducted with pilocarpine hydrochloride.",
        "source": "US FDA label for pilocarpine (Pilocarpine Hydrochloride), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/pilocarpine.json",
        "verbatim": true
      },
      {
        "text": "It is also not known whether pilocarpine hydrochloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity.",
        "source": "US FDA label for pilocarpine (Pilocarpine Hydrochloride), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/pilocarpine.json",
        "verbatim": true
      },
      {
        "text": "Pilocarpine hydrochloride ophthalmic solution should be given to a pregnant woman only if clearly needed.",
        "source": "US FDA label for pilocarpine (Pilocarpine Hydrochloride), section 'pregnancy', retrieved 2026-08-29",
        "cached_file": "labels/pilocarpine.json",
        "verbatim": true
      }
    ],
    "lactation": [
      {
        "text": "It is not known whether this drug is excreted in human milk.",
        "source": "US FDA label for pilocarpine (Pilocarpine Hydrochloride), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/pilocarpine.json",
        "verbatim": true
      },
      {
        "text": "Because many drugs are excreted in human milk, caution should be exercised when pilocarpine hydrochloride ophthalmic solution is administered to a nursing woman.",
        "source": "US FDA label for pilocarpine (Pilocarpine Hydrochloride), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/pilocarpine.json",
        "verbatim": true
      },
      {
        "text": "Pilocarpine hydrochloride ophthalmic solution should be given to a pregnant woman only if clearly needed. 8.3 Nursing Mothers It is not known whether this drug is excreted in human milk.",
        "source": "US FDA label for pilocarpine (Pilocarpine Hydrochloride), section 'use in specific populations', retrieved 2026-08-29",
        "cached_file": "labels/pilocarpine.json",
        "verbatim": true
      }
    ]
  }
}