{
  "schema_version": 1,
  "kind": "drug_profile",
  "generic": "tamoxifen",
  "review_status": "reviewed",
  "origin": "openfda",
  "sections": {
    "adult": [
      {
        "text": "For patients with breast cancer, the recommended daily dose is 20 to 40 mg.",
        "source": "US FDA label for tamoxifen (Tamoxifen Citrate), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/tamoxifen.json",
        "verbatim": true
      },
      {
        "text": "Dosages greater than 20 mg per day should be given in divided doses (morning and evening).",
        "source": "US FDA label for tamoxifen (Tamoxifen Citrate), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/tamoxifen.json",
        "verbatim": true
      },
      {
        "text": "In three single agent adjuvant studies in women, one 10 mg tamoxifen citrate tablet was administered two (ECOG and NATO) or three (Toronto) times a day for two years.",
        "source": "US FDA label for tamoxifen (Tamoxifen Citrate), section 'dosage and administration', retrieved 2026-08-29",
        "cached_file": "labels/tamoxifen.json",
        "verbatim": true
      }
    ],
    "child": [
      {
        "text": "No child dose in this label. That usually means untested in children, not unsuitable - use a paediatric source.",
        "source": "Read and found silent: the US FDA label for tamoxifen (Tamoxifen Citrate), retrieved 2026-08-29",
        "cached_file": "labels/tamoxifen.json",
        "verbatim": false
      }
    ],
    "renal": [
      {
        "text": "No kidney-impairment dose in this label. Not a statement that none is needed.",
        "source": "Read and found silent: the US FDA label for tamoxifen (Tamoxifen Citrate), retrieved 2026-08-29",
        "cached_file": "labels/tamoxifen.json",
        "verbatim": false
      }
    ],
    "hepatic": [
      {
        "text": "No liver-impairment dose in this label. Not a statement that none is needed.",
        "source": "Read and found silent: the US FDA label for tamoxifen (Tamoxifen Citrate), retrieved 2026-08-29",
        "cached_file": "labels/tamoxifen.json",
        "verbatim": false
      }
    ],
    "pregnancy": [
      {
        "text": "Nothing on pregnancy in this label. Treat as unknown, not as safe.",
        "source": "Read and found silent: the US FDA label for tamoxifen (Tamoxifen Citrate), retrieved 2026-08-29",
        "cached_file": "labels/tamoxifen.json",
        "verbatim": false
      }
    ],
    "lactation": [
      {
        "text": "Tamoxifen has been reported to inhibit lactation.",
        "source": "US FDA label for tamoxifen (Tamoxifen Citrate), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/tamoxifen.json",
        "verbatim": true
      },
      {
        "text": "Two placebo-controlled studies in over 150 women have shown that tamoxifen significantly inhibits early postpartum milk production.",
        "source": "US FDA label for tamoxifen (Tamoxifen Citrate), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/tamoxifen.json",
        "verbatim": true
      },
      {
        "text": "In both studies tamoxifen was administered within 24 hours of delivery for between 5 and 18 days.",
        "source": "US FDA label for tamoxifen (Tamoxifen Citrate), section 'nursing mothers', retrieved 2026-08-29",
        "cached_file": "labels/tamoxifen.json",
        "verbatim": true
      }
    ]
  }
}